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Evidence of Interaction Between MAPK1 and STAT3

The interaction score between MAPK1 and STAT3 is 13.40.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismMAPK1 OrthologueSTAT3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 Q9NAD6 0.082

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and STAT3:
Domains in MAPK1Domains in STAT3
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000980 SH2 motif
IPR001217 STAT protein
IPR011992 EF-Hand_type.
IPR012345 STAT_DNA_bd.

The Chi square scores for co-occurrence of domains that are present in MAPK1 and STAT3 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR000980 SH2 motif 82.1364
IPR011009 Protein kinase-like IPR000980 SH2 motif 59.6059
IPR008271 Serine/threonine protein kinase, active site IPR000980 SH2 motif 41.4368
IPR008271 Serine/threonine protein kinase, active site IPR011992 EF-Hand_type. 18.67
IPR002290 Serine/threonine protein kinase IPR000980 SH2 motif 18.5445
IPR000719 Protein kinase IPR011992 EF-Hand_type. 15.5567
IPR002290 Serine/threonine protein kinase IPR011992 EF-Hand_type. 9.84625
IPR011009 Protein kinase-like IPR011992 EF-Hand_type. 9.34155
IPR008271 Serine/threonine protein kinase, active site IPR001217 STAT protein 4.64352
IPR008271 Serine/threonine protein kinase, active site IPR012345 STAT_DNA_bd. 4.64352
IPR003527 MAP kinase IPR000980 SH2 motif 3.65309
IPR000719 Protein kinase IPR012345 STAT_DNA_bd. 2.68473
IPR000719 Protein kinase IPR001217 STAT protein 2.68473
IPR002290 Serine/threonine protein kinase IPR001217 STAT protein 2.22291
IPR002290 Serine/threonine protein kinase IPR012345 STAT_DNA_bd. 2.22291
IPR011009 Protein kinase-like IPR012345 STAT_DNA_bd. 1.35691
IPR011009 Protein kinase-like IPR001217 STAT protein 1.35691
IPR008349 ERK1/2 MAP kinase IPR000980 SH2 motif 0.969135

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in STAT3
  • Green Domain is present in both MAPK1 and STAT3

 0.165
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: STAT3

PTMResidueReference
Phosphotyrosine 705 HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: STAT3

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between MAPK1 and STAT3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andSTAT3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and STAT3 has 1405 interactors of which there are 935 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for STAT3-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.148
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.109
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 94.70 0.044
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.148
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.109
DUSP10 DUSP10, MKP5: Dual specificity protein phosphatase 10 12.60 0.027
CDK2 CDK2: Cell division protein kinase 2 6.80 0.165
HSPD1 6.11 0.025
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.025
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.148
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 2.02 0.050
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.109
PLEK PLEK, P47: Pleckstrin 0.515 0.109
COPS5 COPS5, CSN5, JAB1: COP9 signalosome complex subunit 5 0.475 0.0704
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.148
CRKL CRKL: Crk-like protein 0.461 0.148
JAK1 0.461 1.30
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.148
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.148
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.148
MSN MSN: Moesin 0.461 0.148
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 1.30
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.148
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.165
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.416 0.049
ELF1 ELF1: ETS-related transcription factor Elf-1 0.416 0.049
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.109
STYXL1 STYXL1, DUSP24, MKSTYX: Serine/threonine/tyrosine-interacting-like protein 1 0.402 0.027
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.148
STK10 STK10: Uncharacterized protein STK10 0.385 0.148
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.148
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.098
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 22.50
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.148
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.372 0.044
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.148
LYN LYN: Tyrosine-protein kinase Lyn 0.372 1.17
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.148
CSK CSK: Tyrosine-protein kinase CSK 0.372 1.17
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.083
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 1.30
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.372 0.025
JUND JUND: Transcription factor jun-D 0.372 0.044
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.148
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 1.30
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 1.17
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.148
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.344 0.209
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.165
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.165
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.165
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.165
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.165
CDK3 CDK3: Cell division protein kinase 3 0.285 0.027
DOK1 DOK1: Docking protein 1 0.275 0.165
JUNB JUNB: Transcription factor jun-B 0.275 0.044
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 1.30
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 8.34
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.148
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.148
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 1.30
HCK N/A 0.275 1.17
ETS1 ETS1, EWSR2: Protein C-ets-1 0.275 0.044
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.275 0.049
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.275 0.025
SYK SYK: Tyrosine-protein kinase SYK 0.275 1.30
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.148
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.275 0.025
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.165
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.260 0.056
GAB2 N/A 0.251 0.165
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 1.30
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.056
BACH1 BACH1: Transcription regulator protein BACH1 0.251 0.049
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.165
EPM2A EPM2A: Laforin 0.244 0.027
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.233 0.040
WASPIP N/A 0.233 0.148
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.148
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.148
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.233 0.075
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.148
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.148
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.148
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.148
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.165
JUN JUN: Transcription factor AP-1 0.225 0.044
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.225 0.025
SH3BP5 N/A 0.225 0.025
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 12.60
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 14.80
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.148
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.148
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.165
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.148
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.225 0.044
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.098
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.225 0.044
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.056
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.056
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.165
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.210 0.049
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.208 0.036
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.165
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.165
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.109
CXorf9 N/A 0.188 0.165
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.148
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.148
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.148
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.188 0.098
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.165
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.148
RPS6KB1 N/A 0.188 0.148
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.056
FNBP1 N/A 0.188 0.148
GMIP GMIP: GEM-interacting protein 0.188 0.075
SEC24B SEC24B: Protein transport protein Sec24B 0.188 0.025
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.174 0.0333
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.050
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.148
PSD TYL: TYL protein 0.171 0.148
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.171 0.044
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.148
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.148
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.165
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.148
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.098
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.165
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.165
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.165
PSCD2 N/A 0.165 0.165
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 1.05
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.165
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.083
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 1.30
MAP2K5 N/A 0.165 0.056
NF2 NF2, SCH: Merlin 0.165 0.165
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.165
ARFGAP1 N/A 0.155 0.04
HD HD, IT15: Huntingtin 0.155 0.028
H1FX H1FX: Histone H1x 0.155 0.049
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.165
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.165
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.165
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.109
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.165
ERF ERF: ETS domain-containing transcription factor ERF 0.152 0.049
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.165
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 1.30
SNCB SNCB: Beta-synuclein 0.152 0.052
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 1.30
ETS2 ETS2: Protein C-ets-2 0.152 0.109
CREB1 CREB1: cAMP response element-binding protein 0.148 0.044
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.148
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.148
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.148
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.148
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.165
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 1.30
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.148
ELMO1 N/A 0.148 0.148
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.148
ARHGEF7 N/A 0.148 0.148
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.148
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.148
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 14.80
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 1.17
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.075
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.146 0.025
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.146 0.025
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.146 0.025
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.139 0.098
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.050
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.165
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.139 0.04
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.148
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.148
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.148
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.148
ATM ATM: Serine-protein kinase ATM 0.139 0.148
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.028
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.148
CD2AP CD2AP: CD2-associated protein 0.139 0.148
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.148
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.139 0.044
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.075
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.148
FYN N/A 0.137 0.265
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.086
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.137 0.030
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.148
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.165
RDX RDX: Radixin 0.136 0.148
VIL2 N/A 0.136 0.148
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.148
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.148
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.136 0.049
STMN1 STMN1, LAP18, OP18: Stathmin 0.136 0.028
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.136 0.044
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.136 0.109
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.132 0.028
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.129 0.028
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.129 0.075
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.0688
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.127 0.056
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.165
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.165
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.127 0.028
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.165
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.165
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.127 0.04
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.028
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.109
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.165
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.165
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.123 0.083
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.165
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.118 0.075
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.118 0.044
NRAS NRAS, HRAS1: GTPase NRas precursor 0.118 0.025
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.114 0.148
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.148
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.075
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.114 0.036
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.148
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.050
CDK5 CDK5: Cell division protein kinase 5 0.114 0.148
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.114 0.044
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.148
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.148
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.114 0.165
RPS10 RPS10: 40S ribosomal protein S10 0.114 0.025
THOC1 THOC1, HPR1: THO complex subunit 1 0.114 0.075
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.148
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.114 0.049
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.050
EDD1 EDD1, EDD, HYD, KIAA0896: E3 ubiquitin-protein ligase EDD1 0.113 0.044
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.148
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 1.17
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.165
ELK1 ELK1: ETS domain-containing protein Elk-1 0.111 0.044
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.148
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.148
STMN2 STMN2, SCG10, SCGN10: Stathmin-2 0.111 0.028
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 1.17
PLD2 PLD2: Phospholipase D2 0.111 0.148
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 1.30
BMX N/A 0.110 1.30
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.109
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.044
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.109 0.052
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.165
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.056
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.109
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.109
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.148
ETV1 ETV1, ER81: ETS translocation variant 1 0.098 0.049
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 1.30
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.165
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.109
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.098
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.098
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 1.17
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.148
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.098
PLD1 PLD1: Phospholipase D1 0.097 0.148
DAB1 DAB1: Disabled homolog 1 0.097 0.148
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.148
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.148
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.148
NBN NBN, NBS, NBS1, P95: Nibrin 0.0971 0.04
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.165
NFATC1 N/A 0.096 0.049
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.096 0.028
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.028
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.096 0.165
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.096 0.109
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.028
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.165
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.165
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.165
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.109
CD44 N/A 0.091 0.04
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.044
PTPRZ1 N/A 0.090 0.044
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 1.30
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.148
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.087 0.028
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.087 0.028
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.087 0.098
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.086 0.148
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.148
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.148
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.148
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.148
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.086 0.148
CTPS CTPS: CTP synthase 1 0.086 0.025
RELA RELA, NFKB3: Transcription factor p65 0.086 0.049
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.148
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.148
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.086 0.025
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.050
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.086 0.025
TP53 TP53, P53: Cellular tumor antigen p53 0.086 0.049
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.086 0.165
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.165
MAPKAPK5 N/A 0.083 0.165
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.165
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.028
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.165
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.056
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.049
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.165
MAPK15 N/A 0.083 0.165
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.049
CASP9 CASP9, MCH6: Caspase-9 precursor 0.083 0.028
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.083 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.165
HES6 HES6: Transcription cofactor HES-6 0.083 0.049
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.165
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.083 0.028
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.083 0.265
ARHGEF3 ARHGEF3: Rho guanine nucleotide exchange factor 3 0.083 0.027
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.044
IRF3 IRF3: Interferon regulatory factor 3 0.080 0.109
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.148
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.025
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.078 0.148
LCP1 LCP1, PLS2: Plastin-2 0.078 0.148
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.078 0.025
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.078 0.025
HNRPK N/A 0.078 0.025
KIAA1012 KIAA1012: Protein TRS85 homolog 0.078 0.025
USP47 USP47: Ubiquitin carboxyl-terminal hydrolase 47 0.078 0.025
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.078 0.025
KLHDC4 N/A 0.078 0.028
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.078 0.025
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.078 0.025
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.165
PRKAA1 N/A 0.077 0.165
LIMK2 LIMK2: LIM domain kinase 2 0.077 0.056
STK16 N/A 0.077 0.165
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.165
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.083
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.165
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.165
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.165
ATP2B1 N/A 0.075 0.049
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.109
FADD FADD, MORT1: Protein FADD 0.075 0.049
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.148
GIT2 N/A 0.075 0.047
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.165
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.075 0.098
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.098
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.165
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.056
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.075
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.148
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.148
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.148
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.075 0.025
CNN2 CNN2: Calponin-2 0.075 0.056
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.148
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.098
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.044
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.148
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.165
TSC2 TSC2, TSC4: Tuberin 0.075 0.028
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 1.17
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.148
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.148
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.148
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.148
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.148
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.075 0.050
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.148
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.148
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.148
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.050
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.165
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.075
PLCB2 0.074 0.027
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.109
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.044
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.071 0.098
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.071 0.025
MCM3 MCM3: DNA replication licensing factor MCM3 0.071 0.036
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.071 0.098
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.070 0.083
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.028
ABCF1 N/A 0.070 0.028
MARK2 N/A 0.070 0.028
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.070 0.028
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.070 0.028
NR5A1 NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1 0.069 0.036
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.069 0.148
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.069 0.148
VDR VDR, NR1I1: Vitamin D3 receptor 0.069 0.036
CDK6 CDK6: Cell division protein kinase 6 0.069 0.165
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.056
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.069 0.050
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.050
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.069 0.148
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.069 0.047
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.165
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.069 0.148
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.069 0.050
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.165
CDK4 CDK4: Cell division protein kinase 4 0.069 0.165
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.069 0.025
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.148
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.148
SCAP2 SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R: Src kinase-associated phosphoprotein 2 0.067 0.027
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.878
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.044
GSK3B N/A 0.063 0.025
COPA COPA: Coatomer subunit alpha 0.063 0.025
ACTG1 ACTB: Actin, cytoplasmic 1 0.063 0.075
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.063 0.075
PTPN11 N/A 0.063 0.025
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.063 0.036
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.063 0.025
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.063 0.025
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.063 0.025
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.063 0.025
CKAP1 TBCB, CG22, CKAP1: Tubulin folding cofactor B 0.063 0.025
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.063 0.050
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.063 0.148
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.063 0.025
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.063 0.025
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.165
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.063 0.036
CARS CARS: Cysteinyl-tRNA synthetase, cytoplasmic 0.063 0.025
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.063 0.025
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.025
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.063 0.075
EXOC2 N/A 0.063 0.075
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.063 0.044
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.047
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.063 0.049
PPARBP N/A 0.063 0.028
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.047
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.063 0.028
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.062 0.028
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.062 0.165
COBL N/A 0.062 0.165
SPTAN1 N/A 0.062 0.165
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.044
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.062 0.109
GRLF1 N/A 0.062 0.083
GTF2F2 N/A 0.060 0.049
VIM VIM: Vimentin 0.060 0.049
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.060 0.049
NUP50 NUP50, NPAP60L, PRO1146: Nucleoporin 50 kDa 0.060 0.027
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.098
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.044
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.057 0.049
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.049
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.109
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.062
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.148
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.056 0.148
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 1.17
ESRRA ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1 0.056 0.04
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.148
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.165
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.148
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.056 0.148
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.148
NR1D1 NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1 0.056 0.036
WEE1 WEE1: Wee1-like protein kinase 0.056 0.165
NOS1 NOS1: Nitric-oxide synthase, brain 0.056 0.083
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.165
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.055 0.049
PPARA PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha 0.055 0.04
TP73 TP73, P73: Tumor protein p73 0.055 0.109
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.054 0.036
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.054 0.044
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.054 0.098
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.054 0.029
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.052 0.049
DNM2 N/A 0.052 0.028
CHUK N/A 0.052 0.028
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.052 0.028
FUBP1 N/A 0.052 0.083
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.052 0.083
MVP MVP, LRP: Major vault protein 0.052 0.052
YWHAQ YWHAQ: 14-3-3 protein theta 0.052 0.028
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.052 0.028
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.052 0.028
API5 N/A 0.052 0.028
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.052 0.028
AHNAK AHNAK: AHNAK protein 0.052 0.028
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.052 0.04
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.052 0.028
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.052 0.028
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.165
SRPR SRPR: Uncharacterized protein SRPR 0.052 0.028
GRB10 N/A 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
PTPRA N/A 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.051 0.098
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.044
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.050
HES1 HES1, HL, HRY: Transcription factor HES-1 0.050 0.044
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.148
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.050 0.165
NR4A1 CDNA FLJ16818 fis, clone TRACH1000193, highly similar to Orphan nuclear receptor 0.050 0.036
ARHGEF18 ARHGEF18: ARHGEF18 protein 0.050 0.027
PLEKHO1 PLEKHO1, CKIP1, OC120, HQ0024c: Pleckstrin homology domain-containing family O m 0.050 0.027
RANBP3 N/A 0.050 0.027
NCF2 NCF2: Neutrophil cytosol factor 2 0.050 0.027
ASB8 ASB8, PP14212: Ankyrin repeat and SOCS box protein 8 0.050 0.027
CDKL5 N/A 0.049 0.165
PGR PGR, NR3C3: Progesterone receptor 0.049 0.04
DAPK2 DAPK2: Death-associated protein kinase 2 0.049 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.109
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.109
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.109
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.049
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.980
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.109
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.109
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.109
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.109
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.109
DYRK3 N/A 0.049 0.148
PPARG CREB3L2-PPARgamma 0.049 0.036
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.049 0.044
MYF5 MYF5: Myogenic factor 5 0.049 0.044
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.165
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.049 0.044
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.148
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.048 0.109
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.048 0.049
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.048 0.028
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.048 0.028
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.047 0.028
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.047 0.040
RAB5B RAB5B: Ras-related protein Rab-5B 0.047 0.025
HDAC3 HDAC3: Histone deacetylase 3 0.046 0.049
EVL N/A 0.046 0.025
CDC23 CDC23: Cell division cycle protein 23 homolog 0.046 0.025
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.046 0.025
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.046 0.044
QARS QARS: Glutaminyl-tRNA synthetase 0.046 0.025
HSPH1 HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa 0.046 0.025
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.046 0.075
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.046 0.025
BRPF1 BRPF1, BR140: Peregrin 0.046 0.083
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.046 0.075
DLG1 N/A 0.046 0.025
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.046 0.075
HDAC4 HDAC4, KIAA0288: Histone deacetylase 4 0.046 0.044
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.046 0.044
GSR GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor 0.046 0.025
WARS WARS, IFI53, WRS: Tryptophanyl-tRNA synthetase, cytoplasmic 0.046 0.025
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.046 0.025
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.046 0.028
XPO1 XPO1, CRM1: Exportin-1 0.046 0.025
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.025
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.046 0.028
LPXN LPXN, LDLP: Leupaxin 0.046 0.075
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.046 0.044
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.046 0.025
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.046 0.148
EIF3S6 EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6 0.046 0.025
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.046 0.075
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.046 0.036
SAPS3 N/A 0.046 0.025
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.025
RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 0.046 0.025
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.046 0.025
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.046 0.025
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.109
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.046
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.046
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.046 0.050
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.109
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.044
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.109
MYO3A MYO3A: Myosin IIIA 0.044 0.165
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.148
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.165
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.148
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.044 0.148
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.165
CNN3 CNN3: Calponin-3 0.044 0.165
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.056
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.148
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.148
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.044 0.148
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.044 0.049
ESR1 ESR1, ESR, NR3A1: Estrogen receptor 0.044 0.04
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.044
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.044
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.098
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.098
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.040
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.043 0.098
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.043 0.044
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.043 0.044
TXN TXN, TRDX, TRX, TRX1: Thioredoxin 0.043 0.028
VAV2 VAV2, RP11-153P4.1-003: Vav 2 oncogene 0.0425 0.028
SAT SAT1, SAT: Diamine acetyltransferase 1 0.0425 0.028
DAPP1 N/A 0.0425 0.028
MPG N/A 0.0425 0.028
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.083
XRCC1 XRCC1: DNA-repair protein XRCC1 0.0425 0.04
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.0425 0.04
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.0425 0.028
PDE4A N/A 0.0425 0.028
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.0425 0.028
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.0425 0.052
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.042 0.051
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.0688
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.878
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.878
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 0.036
LDLRAP1 LDLRAP1, ARH: Low density lipoprotein receptor adapter protein 1 0.041 0.027
SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 0.041 0.027
PLEKHA1 PLEKHA1, TAPP1: Pleckstrin homology domain-containing family A member 1 0.041 0.027
CENTA2 CENTA2: Centaurin-alpha 2 0.041 0.027
MYLIP MYLIP, BZF1, BM-023, PP5242: E3 ubiquitin-protein ligase MYLIP 0.041 0.027
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.098
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.148
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.040 0.148
NEF3 NEFM, NEF3, NFM: Neurofilament medium polypeptide 0.039 0.083
GFAP GFAP: Glial fibrillary acidic protein 0.039 0.083
HDAC2 HDAC2: Histone deacetylase 2 0.038 0.044
KCTD12 KCTD12, C13orf2, KIAA1778, PFET1: BTB/POZ domain-containing protein KCTD12 0.038 0.036
RPL8 RPL8: 60S ribosomal protein L8 0.038 0.028
MYH9 MYH9: Myosin-9 0.038 0.098
RP2 RP2: Protein XRP2 0.038 0.025
RANBP9 RANBP9, RANBPM: Ran-binding protein 9 0.038 0.044
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.038 0.025
LDHB LDHB: L-lactate dehydrogenase B chain 0.038 0.025
GMFB GMFB: Glia maturation factor beta 0.038 0.025
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.038 0.025
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.038 0.036
CREBBP CREBBP, CBP: CREB-binding protein 0.038 0.044
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.038 0.028
APC N/A 0.038 0.025
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.038 0.025
SENP6 SENP6, KIAA0797, FKSG6, SSP1, SUSP1: Sentrin-specific protease 6 0.038 0.025
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.038 0.083
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.038 0.044
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.038 0.047
CFL1 CFL1, CFL: Cofilin-1 0.038 0.025
EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 0.038 0.025
CAT CAT: Catalase 0.038 0.025
CCT8 CCT8: Uncharacterized protein CCT8 0.038 0.025
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.038 0.025
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.038 0.025
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.038 0.025
CHP CHP: Calcium-binding protein p22 0.038 0.047
MDN1 MDN1, KIAA0301: Midasin 0.038 0.025
EEF2 EEF2, EF2: Elongation factor 2 0.038 0.025
BAP1 BAP1, KIAA0272, hucep-6: Ubiquitin carboxyl-terminal hydrolase BAP1 0.038 0.028
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.038 0.025
TPT1 TPT1: Translationally-controlled tumor protein 0.038 0.025
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.038 0.025
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.038 0.028
VCP VCP: Transitional endoplasmic reticulum ATPase 0.038 0.025
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.148
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.037 0.109
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.109
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.109
GHR GHR: Growth hormone receptor precursor 0.037 0.109
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.109
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.037 0.109
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.109
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.109
RAP1GA1 N/A 0.037 0.049
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.044
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.044
CRLF3 N/A 0.036 0.044
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.109
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.109
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.044
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.044
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.109
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.109
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.035 0.044
NEFH NEFH, KIAA0845, NFH: Neurofilament heavy polypeptide 0.034 0.028
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.046
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.0688
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.044
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.044
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.036
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.044
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.033 0.098
RHO RHO, OPN2: Rhodopsin 0.033 0.049
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.049
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.109
PRLR PRLR: Prolactin receptor precursor 0.033 0.109
F3 F3: Tissue factor precursor 0.032 0.109
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.109
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.04
ITGB4 N/A 0.032 0.044
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.109
CP110 N/A 0.032 0.028
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.083
ZYX ZYX: Zyxin 0.032 0.083
MAP2K5 N/A 0.032 0.028
UBAP2 N/A 0.032 0.028
IPO7 IPO7: Uncharacterized protein IPO7 0.032 0.028
YWHAH YWHAH, YWHA1: 14-3-3 protein eta 0.032 0.028
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.032 0.049
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.032 0.049
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.032 0.028
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.044
AP2M1 AP2M1, CLAPM1, KIAA0109: AP-2 complex subunit mu-1 0.032 0.044
RYR2 RYR2: Ryanodine receptor 2 0.031 0.0688
DES DES: Desmin 0.031 0.083
RRAS RRAS: Ras-related protein R-Ras precursor 0.0308 0.025
RHOB RHOB, ARH6, ARHB: Rho-related GTP-binding protein RhoB precursor 0.0308 0.028
PTPN7 PTPN7: Tyrosine-protein phosphatase non-receptor type 7 0.0308 0.027
PHLPP PHLPP, KIAA0606, PLEKHE1, SCOP: PH domain leucine-rich repeat-containing protein 0.0308 0.027
DIP13B APPL2, DIP13B: DCC-interacting protein 13-beta 0.0308 0.027
OPRM1 OPRM1, MOR1: Mu-type opioid receptor 0.030 0.030
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.878
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.098
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.040
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.049
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.044
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.049
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.109
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.878
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.098
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.029 0.036
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.029 0.025
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.029 0.165
WWOX WWOX, FOR, WOX1: WW domain-containing oxidoreductase 0.029 0.025
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.029 0.075
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.029 0.052
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.029 0.036
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.029 0.083
THOP1 THOP1: Thimet oligopeptidase 0.029 0.025
PRDX6 PRDX6, AOP2, KIAA0106: Peroxiredoxin-6 0.029 0.025
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.029 0.075
SYMPK SYMPK, SPK: Symplekin 0.029 0.025
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.029 0.025
DPYSL2 DPYSL2, CRMP2: Dihydropyrimidinase-related protein 2 0.029 0.025
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.029 0.025
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.029 0.083
GAPD GAPDH, GAPD, CDABP0047, OK/SW-cl.12: Glyceraldehyde-3-phosphate dehydrogenase 0.029 0.025
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.029 0.025
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.029 0.075
NME2 NME2, NM23B: Nucleoside diphosphate kinase B 0.029 0.025
ENO1 ENO1, ENO1L1, MBPB1, MPB1: Alpha-enolase 0.029 0.025
AIP AIP, XAP2: AH receptor-interacting protein 0.029 0.075
GPI GPI: Glucose-6-phosphate isomerase 0.029 0.025
AHCYL1 AHCYL1, DCAL, XPVKONA: Putative adenosylhomocysteinase 2 0.029 0.028
PMM1 PMM1, PMMH22: Phosphomannomutase 1 0.029 0.025
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.029 0.025
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.029 0.025
CASP3 CASP3, CPP32: Caspase-3 precursor 0.029 0.028
KIAA0690 N/A 0.029 0.025
DSP DSP: Desmoplakin 0.028 0.049
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
SH2D3A SH2D3A, NSP1, UNQ175/PRO201: SH2 domain-containing protein 3A 0.028 0.028
AHSA2 AHSA2, DKFZp564C236, hCG_15158: Putative uncharacterized protein DKFZp564C236 0.028 0.028
CACNB2 N/A 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
PTPN7 N/A 0.028 0.028
HDAC8 N/A 0.028 0.049
STAP2 Uncharacterized protein ENSP00000317912 0.028 0.028
CDC42 N/A 0.028 0.028
PDE5A PDE5A, PDE5: cGMP-specific 3',5'-cyclic phosphodiesterase 0.028 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.083
AXIN1 0.028 0.083
MATK 0.028 0.028
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.044
PHLDB2 N/A 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
YWHAG YWHAG: 14-3-3 protein gamma 0.028 0.028
ABLIM1 ABLIM1, RP11-317F20.1-001: Actin binding LIM protein 1 0.028 0.028
PPEF1 N/A 0.028 0.056
SIVA SIVA1, SIVA: Apoptosis regulatory protein Siva 0.028 0.028
LNX1 N/A 0.028 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.028
C9orf88 N/A 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.083
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
CASP6 CASP6, MCH2: Caspase-6 precursor 0.028 0.028
NCF4 N/A 0.028 0.028
SLC9A3R2 SLC9A3R2: SLC9A3R2 protein (Fragment) 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.083
PKP4 PKP4: Plakophilin-4 0.028 0.028
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.028 0.083
FOXL2 FOXL2: Forkhead box protein L2 0.028 0.044
RRAD RRAD, RAD: GTP-binding protein RAD 0.028 0.028
RFX1 RFX1: MHC class II regulatory factor RFX1 0.028 0.044
PRPH PRPH, NEF4, PRPH1: Peripherin 0.0277 0.083
RANBP1 RANBP1: Ran-specific GTPase-activating protein 0.028 0.027
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.049
OSBPL6 OSBPL6, ORP6: Oxysterol-binding protein-related protein 6 0.027 0.027
PLEKHA4 PLEKHA4, PEPP1: Pleckstrin homology domain-containing family A member 4 0.027 0.027
VEPH1 VEPH1, KIAA1692, VEPH: Ventricular zone-expressed PH domain-containing protein h 0.027 0.027
APBB1 APBB1, FE65, RIR: Amyloid beta A4 precursor protein-binding family B member 1 0.027 0.027
ASB10 ASB10: Ankyrin repeat and SOCS box protein 10 0.027 0.027
CADPS CADPS, CAPS, CAPS1, KIAA1121: Calcium-dependent secretion activator 1 0.027 0.027
DOK6 DOK6: Uncharacterized protein DOK6 0.027 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.027
FAM43A N/A 0.027 0.027
ARHGEF1 ARHGEF1: Rho guanine nucleotide exchange factor 1 0.027 0.027
SRA1 APBB3, FE65L2: Amyloid beta A4 precursor protein-binding family B member 3 0.027 0.027
CENTB5 KIAA1716, CENTB5: Centaurin-beta 5 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.027
ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 0.027 0.027
OSBPL9 N/A 0.027 0.027
ASB17 ASB17: Ankyrin repeat and SOCS box protein 17 0.027 0.027
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
PLEKHA3 PLEKHA3, FAPP1: Pleckstrin homology domain-containing family A member 3 0.027 0.027
ASB14 ASB14: Ankyrin repeat and SOCS box protein 14 0.027 0.027
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
ASB3 ASB3: ASB3 protein 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
ASB12 ASB12: Ankyrin repeat and SOCS box protein 12 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
ASB7 ASB7: Ankyrin repeat and SOCS box protein 7 0.027 0.027
CADPS2 CADPS2, CAPS2, KIAA1591: Calcium-dependent secretion activator 2 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
RASGRF1 RASGRF1, CDC25: Guanine nucleotide-releasing protein 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.027
PSD3 N/A 0.027 0.027
RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 0.027 0.027
PTPN13 N/A 0.027 0.027
LILRB1 N/A 0.027 0.109
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.109
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.027 0.049
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.044
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.109
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.878
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.878
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.044
TRRAP N/A 0.026 0.028
AANAT AANAT, SNAT: Serotonin N-acetyltransferase 0.026 0.028
AFAP AFAP1, AFAP: Actin filament-associated protein 1 0.026 0.028
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.026 0.052
PHB2 PHB2, BAP, REA: Prohibitin-2 0.026 0.052
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 1.30
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.052
EPN1 N/A 0.026 0.028
RGS4 RGS4: Regulator of G-protein signaling 4 0.026 0.083
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.026 0.052
DCAMKL1 DCLK1, DCAMKL1, DCDC3A, KIAA0369: Serine/threonine-protein kinase DCLK1 0.026 0.028
FANCA FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein 0.026 0.028
ESPL1 N/A 0.026 0.028
MT3 MT3: Metallothionein-3 0.026 0.056
OSTF1 N/A 0.0255 0.027
TNIK TNIK, KIAA0551: TRAF2 and NCK-interacting protein kinase 0.0253 0.051
LMO6 LMO6: LIM domain only protein 6 0.025 0.075
RAD50 RAD50: DNA repair protein RAD50 0.025 0.025
SCRIB N/A 0.025 0.025
UBE2R2 UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2 0.025 0.025
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.083
WRNIP1 WRNIP1, WHIP: ATPase WRNIP1 0.025 0.028
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
BCR N/A 0.025 0.028
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.025
GSN GSN: Gelsolin precursor 0.025 0.028
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.025 0.047
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.028
MYO18A 0.025 0.165
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.025 0.049
EPN2 N/A 0.025 0.025
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.083
NCOA5 NCOA5, KIAA1637: Nuclear receptor coactivator 5 0.025 0.028
G3BP2 G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
SH3PX3 SH3PX3, DKFZp666B159, hCG_1731072: SH3 and PX domain-containing protein 3. 0.025 0.025
DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 0.025 0.025
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.04
SPAST SPAST, KIAA1083, SPG4: Spastin 0.025 0.028
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.148
BRD4 N/A 0.025 0.044
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.044
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.025 0.036
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
BCOR N/A 0.025 0.025
MAP2K3 N/A 0.025 0.025
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.025 0.075
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.109
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.025 0.025
GRK6 N/A 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.052
PRKCB1 N/A 0.025 0.025
HSPA8 HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.028
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.052
RAC1 N/A 0.025 0.025
DBNL N/A 0.025 0.025
CAMK2A N/A 0.025 0.025
RSN CLIP1, CYLN1, RSN: CAP-Gly domain-containing linker protein 1 0.025 0.028
CFL2 CFL2: Cofilin-2 0.025 0.025
SVIL SVIL: Supervillin 0.025 0.025
HDAC7A N/A 0.025 0.044
DCP1B DCP1B: mRNA-decapping enzyme 1B 0.025 0.025
CAMKK1 N/A 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.025 0.025
CHTF18 RUVBL, CHTF18: Protein CTF18 homolog. 0.025 0.025
PDE4B PDE4B, DPDE4: cAMP-specific 3',5'-cyclic phosphodiesterase 4B 0.025 0.025
0.228
Total Score 13.40