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Evidence of Interaction Between MAPK1 and PDGFRB

The interaction score between MAPK1 and PDGFRB is 5.34.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and PDGFRB = -0.31

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.30E-3
Orthology
OrganismMAPK1 OrthologuePDGFRB OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 P34892 0.084
worm P39745 1 O76698 1
worm P39745 1 Q21038 1
worm P39745 1 Q21041 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and PDGFRB:
Domains in MAPK1Domains in PDGFRB
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR013151 Immunoglobulin.

The Chi square scores for co-occurrence of domains that are present in MAPK1 and PDGFRB are listed below.

Domain 1Domain 2Chi Square
IPR008271 Serine/threonine protein kinase, active site IPR007110 Immunoglobulin-like 49.9657
IPR008271 Serine/threonine protein kinase, active site IPR008266 Tyrosine protein kinase, active site 41.8291
IPR000719 Protein kinase IPR000719 Protein kinase 30.6895
IPR008271 Serine/threonine protein kinase, active site IPR003599 Immunoglobulin subtype 27.8873
IPR011009 Protein kinase-like IPR011009 Protein kinase-like 26.2215
IPR002290 Serine/threonine protein kinase IPR008266 Tyrosine protein kinase, active site 25.0766
IPR008271 Serine/threonine protein kinase, active site IPR003598 Immunoglobulin C-2 type 17.9033
IPR011009 Protein kinase-like IPR007110 Immunoglobulin-like 16.6203
IPR000719 Protein kinase IPR007110 Immunoglobulin-like 11.3335
IPR011009 Protein kinase-like IPR003599 Immunoglobulin subtype 8.86948
IPR008271 Serine/threonine protein kinase, active site IPR001245 Tyrosine protein kinase 8.08585
IPR000719 Protein kinase IPR008266 Tyrosine protein kinase, active site 6.98997
IPR008271 Serine/threonine protein kinase, active site IPR000719 Protein kinase 6.25263
IPR002290 Serine/threonine protein kinase IPR001245 Tyrosine protein kinase 5.09618
IPR008349 ERK1/2 MAP kinase IPR000719 Protein kinase 4.26499
IPR000719 Protein kinase IPR003599 Immunoglobulin subtype 3.60485
IPR000719 Protein kinase IPR011009 Protein kinase-like 2.94434
IPR003527 MAP kinase IPR000719 Protein kinase 2.81413
IPR011009 Protein kinase-like IPR013151 Immunoglobulin. 2.74789
IPR002290 Serine/threonine protein kinase IPR011009 Protein kinase-like 2.72953
IPR000719 Protein kinase IPR001245 Tyrosine protein kinase 2.31134
IPR008271 Serine/threonine protein kinase, active site IPR011009 Protein kinase-like 2.11823
IPR000719 Protein kinase IPR013151 Immunoglobulin. 1.81655
IPR003527 MAP kinase IPR001245 Tyrosine protein kinase 1.50703
IPR011009 Protein kinase-like IPR003598 Immunoglobulin C-2 type 1.32999
IPR002290 Serine/threonine protein kinase IPR000719 Protein kinase 0.986464
IPR011009 Protein kinase-like IPR001245 Tyrosine protein kinase 0.178275
IPR003527 MAP kinase IPR011009 Protein kinase-like 0.150555
IPR000719 Protein kinase IPR003598 Immunoglobulin C-2 type 0.142823
IPR011009 Protein kinase-like IPR001824 Receptor tyrosine kinase, class III 0.099805
IPR008349 ERK1/2 MAP kinase IPR011009 Protein kinase-like 0.0192176
IPR011009 Protein kinase-like IPR009134 Vascular endothelial growth factor receptor, VEGFR 0.00926039
IPR011009 Protein kinase-like IPR008266 Tyrosine protein kinase, active site 0.00724826
IPR000719 Protein kinase IPR001824 Receptor tyrosine kinase, class III 0.000102653
IPR000719 Protein kinase IPR009134 Vascular endothelial growth factor receptor, VEGFR 0.0000462868
IPR008349 ERK1/2 MAP kinase IPR001245 Tyrosine protein kinase 0.0000302204

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in PDGFRB
  • Green Domain is present in both MAPK1 and PDGFRB

 0.049
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: PDGFRB

PTMResidueReference
Dephosphorylation 562 PubMed, HPRD
Dephosphorylation 579 PubMed, HPRD
Dephosphorylation 740 PubMed, HPRD
Dephosphorylation 751 PubMed, HPRD
Dephosphorylation 771 PubMed, HPRD
Dephosphorylation 857 PubMed, HPRD
Dephosphorylation 1009 PubMed, HPRD
Dephosphorylation 1021 PubMed, HPRD
Phosphorylation 579 PubMed, HPRD
Phosphorylation 581 PubMed, HPRD
Phosphorylation 716 PubMed, HPRD
Phosphorylation 740 PubMed, HPRD
Phosphorylation 751 PubMed, HPRD
Phosphorylation 763 PubMed, HPRD
Phosphorylation 771 PubMed, HPRD
Phosphorylation 775 PubMed, HPRD
Phosphorylation 857 PubMed, HPRD
Phosphorylation 1009 PubMed, HPRD
Phosphorylation 1021 PubMed, HPRD
Phosphotyrosine 751 PubMed, HPRD
Phosphotyrosine 857 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: PDGFRB

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between MAPK1 and PDGFRB that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andPDGFRB. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and PDGFRB has 1323 interactors of which there are 626 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for PDGFRB-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.033
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.041
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 94.70 0.046
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.098
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.062
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 10.50 19.20
CDK2 CDK2: Cell division protein kinase 2 6.80 0.026
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 4.15 0.029
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.029
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 2.53 21.50
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.065
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 1.42 0.181
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.063
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 0.025
PLEK PLEK, P47: Pleckstrin 0.515 0.046
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.064
CRKL CRKL: Crk-like protein 0.461 536.00
JAK1 0.461 0.644
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.058
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.065
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 281.00
MSN MSN: Moesin 0.461 0.058
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.654
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.065
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.456 43.90
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.581
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.360
STK10 STK10: Uncharacterized protein STK10 0.385 0.029
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.058
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.318
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 250.00
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.065
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.065
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.586
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 250.00
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.586
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.0727
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 250.00
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.372 0.029
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.029
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.520
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 281.00
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.052
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.344 0.916
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.081
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.0727
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.731
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.654
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.065
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.307 0.046
DOK1 DOK1: Docking protein 1 0.275 0.058
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.654
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 372.00
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.064
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.065
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.644
HCK N/A 0.275 250.00
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.275 0.026
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.654
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.033
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.275 0.029
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.0727
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.260 0.065
GAB2 N/A 0.251 0.065
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.581
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.251 0.036
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.065
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.072
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.233 0.041
WASPIP N/A 0.233 0.029
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.065
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.058
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.233 0.029
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.029
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.026
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.029
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.029
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.065
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.225 0.029
SH3BP5 N/A 0.225 0.073
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 600.00
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.286
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.058
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.058
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 281.00
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.073
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.046
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.058
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.210 0.032
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.033
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.192 0.058
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.065
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.581
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.320
CXorf9 N/A 0.188 0.065
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.188 0.058
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.052
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.029
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.188 0.041
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.029
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.029
RPS6KB1 N/A 0.188 0.026
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.065
FNBP1 N/A 0.188 0.065
GMIP GMIP: GEM-interacting protein 0.188 0.065
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.174 0.096
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.520
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 600.00
PSD TYL: TYL protein 0.171 0.058
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.058
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.058
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.064
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.026
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.037
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.980
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PSCD2 N/A 0.165 0.109
NSBP1 NSBP1: Nucleosome-binding protein 1 0.165 0.0688
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.980
BID BID: BH3-interacting domain death agonist 0.165 0.034
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.980
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.980
MAP2K5 N/A 0.165 0.049
NF2 NF2, SCH: Merlin 0.165 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.980
HD HD, IT15: Huntingtin 0.155 0.033
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.029
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.155 0.032
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.032
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.123
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.644
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.072
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 1.13
SNCB SNCB: Beta-synuclein 0.152 0.065
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.731
ETS2 ETS2: Protein C-ets-2 0.152 0.025
CREB1 CREB1: cAMP response element-binding protein 0.148 0.030
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.098
CCNT2 CCNT2: Cyclin-T2 0.148 0.030
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.098
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.098
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.098
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.098
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.030
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 422.00
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.980
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.980
STAT3 0.148 0.878
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.098
ELMO1 N/A 0.148 0.098
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.098
ARHGEF7 N/A 0.148 0.098
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.098
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.030
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 232.00
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 1.01E3
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.044
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.029
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.139 0.029
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.026
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.029
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.026
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.026
ATM ATM: Serine-protein kinase ATM 0.139 0.029
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.026
CD2AP CD2AP: CD2-associated protein 0.139 0.065
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.044
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.065
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.026
FYN N/A 0.137 0.129
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.086
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.058
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.058
RDX RDX: Radixin 0.136 0.073
VIL2 N/A 0.136 0.064
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.073
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.033
STMN1 STMN1, LAP18, OP18: Stathmin 0.136 0.052
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.136 0.041
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.046
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.032
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.033
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.033
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.033
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.124 0.031
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.110
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.644
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.081
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.126
CDC37 CDC37: Hsp90 co-chaperone Cdc37 0.116 0.031
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.065
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.029
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.058
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.058
CDK5 CDK5: Cell division protein kinase 5 0.114 0.026
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.065
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.029
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.114 0.026
THOC1 THOC1, HPR1: THO complex subunit 1 0.114 0.029
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.029
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.029
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.090
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.808
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.586
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.090
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 84.00
STMN2 STMN2, SCG10, SCGN10: Stathmin-2 0.111 0.072
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 277.00
PLD2 PLD2: Phospholipase D2 0.111 0.073
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.731
BMX N/A 0.110 0.902
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.109 0.081
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.072
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.072
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.051
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.355
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 315.00
ETV1 ETV1, ER81: ETS translocation variant 1 0.098 0.025
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.581
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.126
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.148
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.165
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.148
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.655
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.064
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 137.00
PLD1 PLD1: Phospholipase D1 0.097 0.073
DAB1 DAB1: Disabled homolog 1 0.097 0.064
TST TST: Thiosulfate sulfurtransferase 0.097 0.073
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.064
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.148
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.090
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.072
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.033
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.065
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.0727
GNA14 GNA14: Guanine nucleotide-binding protein alpha-14 subunit 0.095 4.65
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.109
CD44 N/A 0.091 0.055
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.044
PTPRZ1 N/A 0.090 0.098
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 277.00
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.090
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.087 0.033
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 12.50
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.026
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.051
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.086 0.029
CTPS CTPS: CTP synthase 1 0.086 0.029
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.041
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.033
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.086 0.029
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 12.50
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.086 0.029
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.086 0.033
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.109
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.04
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.109
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.049
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.049
MAPK15 N/A 0.083 0.049
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.049
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.083 0.049
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.083 0.129
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.099
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.171
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.029
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.078 0.029
LCP1 LCP1, PLS2: Plastin-2 0.078 0.065
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.032
PRKAA1 N/A 0.077 0.032
STK16 N/A 0.077 0.032
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.098
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.032
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.032
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.065
ATP2B1 N/A 0.075 0.056
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.098
FADD FADD, MORT1: Protein FADD 0.075 0.055
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.109
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.030
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.098
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.109
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.098
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.044
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.044
SNX3 N/A 0.075 0.098
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.098
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.075 0.044
CNN2 CNN2: Calponin-2 0.075 0.109
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.030
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.030
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.098
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.075
TSC2 TSC2, TSC4: Tuberin 0.075 0.049
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.098
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.098
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.098
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.044
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.044
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.044
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.098
RIN3 N/A 0.074 0.115
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.123
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.073 0.049
GABRR1 N/A 0.0727 0.062
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.123
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.071 0.033
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.071 0.026
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.071 0.033
CAPNS1 CAPNS1, CAPN4, CAPNS: Calpain small subunit 1 0.070 0.072
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.033
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.070 0.030
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.069 0.033
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.069 0.033
CDK6 CDK6: Cell division protein kinase 6 0.069 0.032
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.065
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.064
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.033
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.069 0.029
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.072
CDK4 CDK4: Cell division protein kinase 4 0.069 0.029
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.069 0.029
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.041
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.044
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 112.00
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.372
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.063 0.072
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.063 0.065
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.063 0.029
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.063 0.029
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.063 0.029
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.063 0.073
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.052
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.052
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.062 0.037
COBL N/A 0.062 0.032
SPTAN1 N/A 0.062 0.081
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.049
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.062 0.051
GRLF1 N/A 0.062 0.072
CHAT CHAT: Choline O-acetyltransferase 0.062 0.030
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.225
GLRA1 N/A 0.058 0.056
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.275
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.109
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.077
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.123
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.056 0.029
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.026
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.026
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.056 0.029
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.056 0.029
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 74.00
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.033
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.029
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.029
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.064
WEE1 WEE1: Wee1-like protein kinase 0.056 0.032
SALF GTF2A1L, ALF, GTF2A1LF: TFIIA-alpha and beta-like factor 0.056 0.0513
CDKN1A CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi 0.055 0.039
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.037
TP73 TP73, P73: Tumor protein p73 0.055 0.051
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.054 0.041
EIF4EBP1 EIF4EBP1: Eukaryotic translation initiation factor 4E-binding protein 1 0.053 0.0273
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.053 0.030
FUBP1 N/A 0.052 0.033
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.037
MT1H N/A 0.051 0.051
PPP1R14C PPP1R14C, KEPI: Protein phosphatase 1 regulatory subunit 14C 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
GRB10 N/A 0.051 0.617
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
PTPRA N/A 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
RAPH1 N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
PPP1R1B PPP1R1B, DARPP32: Protein phosphatase 1 regulatory subunit 1B 0.051 0.051
EVL EVL, RNB6: Ena/VASP-like protein 0.051 0.051
C9orf88 N/A 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
CRK CRK: Proto-oncogene C-crk 0.051 0.617
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.051 0.072
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.056
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.040
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.181
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.050 0.0453
CDKL5 N/A 0.049 0.0453
KRT1 KRT1, KRTA: Keratin, type II cytoskeletal 1 0.049 0.0263
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.165
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.083
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.165
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.165
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.083
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.165
EDA N/A 0.049 0.083
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.165
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.165
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.083
ATP2A3 ATP2A3: Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 0.049 0.083
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.083
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.165
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.165
DYRK3 N/A 0.049 0.033
AQP1 AQP1, CHIP28: Aquaporin-1 0.049 0.033
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.026
AQP2 AQP2: Aquaporin-2 0.049 0.027
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.073
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.048 0.041
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.047 0.044
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.047 0.062
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.026
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.046 0.026
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.046 0.029
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.056
TBC1D4 TBC1D4: TBC1D4 protein 0.046 0.051
PPP1R14A PPP1R14A, CPI17, PPP1INL: Protein phosphatase 1 regulatory subunit 14A 0.046 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.046 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 265.00
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.553
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.046 0.030
ACSL1 ACSL1, FACL1, FACL2, LACS, LACS1, LACS2: Long-chain-fatty-acid--CoA ligase 1 0.046 0.026
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.046 0.064
MT1X MT1X: Metallothionein-1X 0.046 0.126
MT2A MT2A, CES1, MT2: Metallothionein-2 0.046 0.126
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.109
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.062
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.098
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0453 0.031
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.045 0.100
CGA CGA: Glycoprotein hormones alpha chain precursor 0.045 0.081
TSHB TSHB: Thyrotropin subunit beta precursor 0.045 0.072
FSHB FSHB: Follitropin subunit beta precursor 0.045 0.072
LHB LHB: Lutropin subunit beta precursor 0.045 0.072
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.045 0.100
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.110
MYO3A MYO3A: Myosin IIIA 0.044 0.041
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.051
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.033
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.051
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.044 0.041
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.126
CNN3 CNN3: Calponin-3 0.044 0.202
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.073
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.073
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.113
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.044 0.033
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.075
AQP4 AQP4: Aquaporin-4 0.044 0.047
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.075
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.047
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.025
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.075
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.025
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.148
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.043 0.037
AKR7A2 AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2 0.043 0.029
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.065
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.042 0.030
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.041 0.031
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.041 0.090
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.245
MT1F MT1F, PRO0376: Metallothionein-1F 0.041 0.100
INHA INHA: Inhibin alpha chain precursor 0.041 0.100
FGF5 FGF5: Fibroblast growth factor 5 precursor 0.041 0.065
NDP NDP: Norrin precursor 0.041 0.081
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.041 0.081
LOC645745 MT1H: Metallothionein-1H 0.041 0.100
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 112.00
GLRB GLRB: Glycine receptor subunit beta precursor 0.041 0.044
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.088
SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 0.041 0.129
FGF9 FGF9: Glia-activating factor precursor 0.041 0.064
BMP7 BMP7, OP1: Bone morphogenetic protein 7 precursor 0.041 0.064
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.052
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.052
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.088
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.049
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.088
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 15.80
MYH9 MYH9: Myosin-9 0.038 0.041
CHP CHP: Calcium-binding protein p22 0.038 0.113
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.064
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.037 0.049
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.098
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.110
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.098
GHR GHR: Growth hormone receptor precursor 0.037 0.191
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.123
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.037 0.056
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.109
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.098
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.098
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.110
CRLF3 N/A 0.036 0.088
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.110
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.110
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.109
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.098
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.036 0.056
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.098
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.098
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.110
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.030
MT1E MT1E: Metallothionein-1E 0.034 0.047
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.0338 0.047
MAL2 MAL2: Protein MAL2 0.034 0.034
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.109
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.033 0.028
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.028
SCARB2 SCARB2, CD36L2, LIMPII: Lysosome membrane protein 2 0.033 0.114
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.0308
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.035
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.033 0.056
RHO RHO, OPN2: Rhodopsin 0.033 0.062
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.127
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.191
PRLR PRLR: Prolactin receptor precursor 0.033 0.123
F3 F3: Tissue factor precursor 0.032 0.123
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.123
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.109
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.109
ITGB4 N/A 0.032 0.109
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.055
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.081
IPO7 IPO7: Uncharacterized protein IPO7 0.032 0.0727
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.032 0.029
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.110
RYR2 RYR2: Ryanodine receptor 2 0.031 0.045
PPP1R14D PPP1R14D, GBPI: Protein phosphatase 1 regulatory subunit 14D 0.031 0.038
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.030 0.0338
PPP1R1A PPP1R1A, IPP1: Protein phosphatase 1 regulatory subunit 1A 0.030 0.038
GJA5 GJA5: Gap junction alpha-5 protein 0.030 0.038
PEBP1 PEBP1, PBP, PEBP: Phosphatidylethanolamine-binding protein 1 0.030 0.034
SYNGR2 SYNGR2, UNQ352/PRO615: Synaptogyrin-2 0.030 0.030
C1QBP C1QBP, GC1QBP, HABP1, SF2P32: Complement component 1 Q subcomponent-binding prot 0.030 0.030
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 532.00
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.233
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.111
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.055
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.123
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.109
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.062
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.055
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 82.20
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.029
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.029 0.037
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.029 0.064
THOP1 THOP1: Thimet oligopeptidase 0.029 0.058
SYMPK SYMPK, SPK: Symplekin 0.029 0.026
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.029 0.029
KIAA0690 N/A 0.029 0.029
DSP DSP: Desmoplakin 0.028 0.04
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.028 0.04
SYTL4 Endocrine transmitter regulatory protein 0.028 0.034
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.109
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.109
PPEF1 N/A 0.028 0.109
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.04
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.028 0.064
VAV3 VAV3: Protein vav-3 0.028 0.128
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.035
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.217
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.217
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.217
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.217
LILRB1 N/A 0.027 0.110
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.098
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.109
CD69 CD69: Early activation antigen CD69 0.027 0.098
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.110
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.096
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.035
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.111
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.097
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.0308
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.081
DBN1 DBN1, D0S117E: Drebrin 0.026 0.030
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.065
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.026 0.081
MT3 MT3: Metallothionein-3 0.026 0.049
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.025 0.072
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.025 0.072
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.081
F5 F5: Coagulation factor V precursor 0.025 0.072
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.025 0.098
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.044
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.098
GSN GSN: Gelsolin precursor 0.025 0.036
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.025 0.098
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.030
MYO18A 0.025 0.049
COTL1 COTL1, CLP: Coactosin-like protein 0.025 0.04
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.044
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.0688
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.098
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.025 0.044
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.030
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.109
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.025 0.098
NIPBL N/A 0.025 0.044
CFL2 CFL2: Cofilin-2 0.025 0.036
SVIL SVIL: Supervillin 0.025 0.036
0.572
Total Score 5.34