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Evidence of Interaction Between MAPK1 and KIT

The interaction score between MAPK1 and KIT is 9.29.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and KIT = 0.17

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology
OrganismMAPK1 OrthologueKIT OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 O76698 0.132
worm P39745 1 Q21038 0.132
worm P39745 1 Q21041 0.132

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and KIT:
Domains in MAPK1Domains in KIT
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR013151 Immunoglobulin.

The Chi square scores for co-occurrence of domains that are present in MAPK1 and KIT are listed below.

Domain 1Domain 2Chi Square
IPR008271 Serine/threonine protein kinase, active site IPR007110 Immunoglobulin-like 49.9657
IPR008271 Serine/threonine protein kinase, active site IPR008266 Tyrosine protein kinase, active site 41.8291
IPR000719 Protein kinase IPR000719 Protein kinase 30.6895
IPR008271 Serine/threonine protein kinase, active site IPR003599 Immunoglobulin subtype 27.8873
IPR011009 Protein kinase-like IPR011009 Protein kinase-like 26.2215
IPR002290 Serine/threonine protein kinase IPR008266 Tyrosine protein kinase, active site 25.0766
IPR008271 Serine/threonine protein kinase, active site IPR003598 Immunoglobulin C-2 type 17.9033
IPR011009 Protein kinase-like IPR007110 Immunoglobulin-like 16.6203
IPR000719 Protein kinase IPR007110 Immunoglobulin-like 11.3335
IPR011009 Protein kinase-like IPR003599 Immunoglobulin subtype 8.86948
IPR008271 Serine/threonine protein kinase, active site IPR001245 Tyrosine protein kinase 8.08585
IPR000719 Protein kinase IPR008266 Tyrosine protein kinase, active site 6.98997
IPR008271 Serine/threonine protein kinase, active site IPR000719 Protein kinase 6.25263
IPR002290 Serine/threonine protein kinase IPR001245 Tyrosine protein kinase 5.09618
IPR008349 ERK1/2 MAP kinase IPR000719 Protein kinase 4.26499
IPR000719 Protein kinase IPR003599 Immunoglobulin subtype 3.60485
IPR000719 Protein kinase IPR011009 Protein kinase-like 2.94434
IPR003527 MAP kinase IPR000719 Protein kinase 2.81413
IPR011009 Protein kinase-like IPR013151 Immunoglobulin. 2.74789
IPR002290 Serine/threonine protein kinase IPR011009 Protein kinase-like 2.72953
IPR000719 Protein kinase IPR001245 Tyrosine protein kinase 2.31134
IPR008271 Serine/threonine protein kinase, active site IPR011009 Protein kinase-like 2.11823
IPR000719 Protein kinase IPR013151 Immunoglobulin. 1.81655
IPR003527 MAP kinase IPR001245 Tyrosine protein kinase 1.50703
IPR011009 Protein kinase-like IPR003598 Immunoglobulin C-2 type 1.32999
IPR002290 Serine/threonine protein kinase IPR000719 Protein kinase 0.986464
IPR011009 Protein kinase-like IPR001245 Tyrosine protein kinase 0.178275
IPR003527 MAP kinase IPR011009 Protein kinase-like 0.150555
IPR000719 Protein kinase IPR003598 Immunoglobulin C-2 type 0.142823
IPR011009 Protein kinase-like IPR001824 Receptor tyrosine kinase, class III 0.099805
IPR008349 ERK1/2 MAP kinase IPR011009 Protein kinase-like 0.0192176
IPR011009 Protein kinase-like IPR009134 Vascular endothelial growth factor receptor, VEGFR 0.00926039
IPR011009 Protein kinase-like IPR008266 Tyrosine protein kinase, active site 0.00724826
IPR000719 Protein kinase IPR001824 Receptor tyrosine kinase, class III 0.000102653
IPR000719 Protein kinase IPR009134 Vascular endothelial growth factor receptor, VEGFR 0.0000462868
IPR008349 ERK1/2 MAP kinase IPR001245 Tyrosine protein kinase 0.0000302204

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in KIT
  • Green Domain is present in both MAPK1 and KIT

 0.049
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: KIT

PTMResidueReference
Dephosphorylation 570 PubMed, HPRD
N-linked 130 PubMed, HPRD
Phosphorylation 545 PubMed, HPRD
Phosphorylation 547 PubMed, HPRD
Phosphorylation 553 PubMed, HPRD
Phosphorylation 568 PubMed, HPRD
Phosphorylation 570 PubMed, HPRD
Phosphorylation 703 PubMed, HPRD
Phosphorylation 721 PubMed, HPRD
Phosphorylation 730 PubMed, HPRD
Phosphorylation 741 PubMed, HPRD
Phosphorylation 746 PubMed, HPRD
Phosphorylation 747 PubMed, HPRD
Phosphorylation 821 PubMed, HPRD
Phosphorylation 900 PubMed, HPRD
Phosphorylation 936 PubMed, HPRD
Phosphorylation 959 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: KIT

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Transitive Score

The common interactors between MAPK1 and KIT that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andKIT. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and KIT has 1344 interactors of which there are 669 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for KIT-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.041
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.046
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 94.70 0.041
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.098
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.062
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 10.50 11.10
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 7.38 0.028
CDK2 CDK2: Cell division protein kinase 2 6.80 0.041
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 4.15 0.051
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.067
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 2.53 11.10
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.073
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 1.42 0.064
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 1.03 0.038
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.063
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 0.025
PLEK PLEK, P47: Pleckstrin 0.515 0.051
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.073
CRKL CRKL: Crk-like protein 0.461 388.00
JAK1 0.461 0.731
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.090
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.073
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.655
MSN MSN: Moesin 0.461 0.073
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.902
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.073
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.456 8.99
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.644
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.403
STK10 STK10: Uncharacterized protein STK10 0.385 0.033
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.073
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.361
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.577
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.064
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.372 0.035
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.148
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.577
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.808
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.655
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.100
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.808
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.372 0.051
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.372 0.028
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.051
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.577
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.577
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.073
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.344 2.08
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.065
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.081
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.644
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.731
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.072
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.307 0.105
DOK1 DOK1: Docking protein 1 0.275 0.090
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.902
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 214.00
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.090
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.073
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.644
HCK N/A 0.275 0.577
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.275 0.033
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.902
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.051
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.275 0.041
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.081
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.260 0.081
GAB2 N/A 0.251 0.126
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.644
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.251 0.0794
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.072
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.081
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.233 0.094
WASPIP N/A 0.233 0.029
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.073
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.233 0.035
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.073
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.233 0.041
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.041
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.033
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.029
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.033
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.073
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.225 0.033
SH3BP5 N/A 0.225 0.073
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 487.00
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.318
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.064
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.113
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.577
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.064
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.094
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.225 0.056
CCNH CCNH: Cyclin-H 0.225 0.028
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.072
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.210 0.032
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.0453
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.192 0.064
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.166
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.731
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.497
CXorf9 N/A 0.188 0.064
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.188 0.073
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.181
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.067
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.033
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.188 0.071
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.057
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.051
RPS6KB1 N/A 0.188 0.041
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.181
FNBP1 N/A 0.188 0.073
GMIP GMIP: GEM-interacting protein 0.188 0.064
SEC24B SEC24B: Protein transport protein Sec24B 0.188 0.041
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.174 0.096
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.655
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 315.00
PSD TYL: TYL protein 0.171 0.073
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.090
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.090
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.090
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.067
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.046
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.980
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PSCD2 N/A 0.165 0.109
NSBP1 NSBP1: Nucleosome-binding protein 1 0.165 0.0688
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.980
BID BID: BH3-interacting domain death agonist 0.165 0.034
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.980
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.980
MAP2K5 N/A 0.165 0.049
NF2 NF2, SCH: Merlin 0.165 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.980
HD HD, IT15: Huntingtin 0.155 0.0453
H1FX H1FX: Histone H1x 0.155 0.039
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.037
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.155 0.032
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.0453
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.123
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.644
ERF ERF: ETS domain-containing transcription factor ERF 0.152 0.025
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.081
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.902
SNCB SNCB: Beta-synuclein 0.152 0.081
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.731
ETS2 ETS2: Protein C-ets-2 0.152 0.0513
CREB1 CREB1: cAMP response element-binding protein 0.148 0.030
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.098
CCNT2 CCNT2: Cyclin-T2 0.148 0.030
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.098
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.098
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.098
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.098
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.030
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.878
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.980
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.980
STAT3 0.148 0.878
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.098
ELMO1 N/A 0.148 0.098
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.098
ARHGEF7 N/A 0.148 0.098
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.098
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.030
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.483
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 422.00
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.044
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.051
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.139 0.051
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.041
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.139 0.031
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.033
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.033
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.041
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.026
ATM ATM: Serine-protein kinase ATM 0.139 0.029
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.075
CD2AP CD2AP: CD2-associated protein 0.139 0.090
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.069
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.139 0.028
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.073
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.051
FYN N/A 0.137 0.162
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.086
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.073
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.073
RDX RDX: Radixin 0.136 0.090
VIL2 N/A 0.136 0.064
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.090
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.041
STMN1 STMN1, LAP18, OP18: Stathmin 0.136 0.113
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.136 0.051
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.051
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.032
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.037
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.0453
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.075
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.124 0.034
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.109
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.731
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.072
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.081
CDC37 CDC37: Hsp90 co-chaperone Cdc37 0.116 0.042
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.113
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.029
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.114 0.035
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.090
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.064
CDK5 CDK5: Cell division protein kinase 5 0.114 0.041
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.114 0.035
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.113
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.041
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.114 0.029
THOC1 THOC1, HPR1: THO complex subunit 1 0.114 0.0818
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.041
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.067
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.111 0.046
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.064
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.808
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.577
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.090
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 35.00
STMN2 STMN2, SCG10, SCGN10: Stathmin-2 0.111 0.100
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.808
PLD2 PLD2: Phospholipase D2 0.111 0.073
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.644
BMX N/A 0.110 0.654
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.109 0.100
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.081
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.072
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.063
HMGA2 HMGA2, HMGIC: High mobility group protein HMGI-C 0.109 0.025
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.355
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.577
ETV1 ETV1, ER81: ETS translocation variant 1 0.098 0.025
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.581
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.081
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.148
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.165
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.148
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.655
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.090
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.318
PLD1 PLD1: Phospholipase D1 0.097 0.058
DAB1 DAB1: Disabled homolog 1 0.097 0.064
TST TST: Thiosulfate sulfurtransferase 0.097 0.073
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.073
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.064
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.090
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.081
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.096 0.025
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.0453
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.100
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.096 0.039
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.065
GNA14 GNA14: Guanine nucleotide-binding protein alpha-14 subunit 0.095 1.57
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.109
CD44 N/A 0.091 0.055
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.049
PTPRZ1 N/A 0.090 0.152
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.520
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.073
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.087 0.041
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.033
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.029
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.029
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.086 0.041
CTPS CTPS: CTP synthase 1 0.086 0.051
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.029
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.051
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.086 0.033
NPM1 NPM1, NPM: Nucleophosmin 0.086 0.031
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.041
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.086 0.067
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.086 0.075
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.109
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.04
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.109
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.049
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.049
MAPK15 N/A 0.083 0.049
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.049
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.083 0.049
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.083 0.200
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.136
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.097
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.041
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.078 0.041
LCP1 LCP1, PLS2: Plastin-2 0.078 0.064
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.0453
MYB MYB: Myb proto-oncogene protein 0.077 0.039
PRKAA1 N/A 0.077 0.032
STK16 N/A 0.077 0.032
TSPYL2 TSPYL2, CDA1, HRIHFB2216, DENTT, TSPX: Testis-specific Y-encoded-like protein 2 0.077 0.025
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.152
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.037
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.037
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.072
CMTM6 CMTM6, CKLFSF6: CKLF-like MARVEL transmembrane domain-containing protein 6 0.076 0.025
ATP2B1 N/A 0.075 0.077
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.152
FADD FADD, MORT1: Protein FADD 0.075 0.077
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.109
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.030
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.098
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.109
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.098
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.044
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.044
SNX3 N/A 0.075 0.098
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.098
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.075 0.044
CNN2 CNN2: Calponin-2 0.075 0.109
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.030
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.030
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.098
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.075
TSC2 TSC2, TSC4: Tuberin 0.075 0.049
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.098
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.098
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.098
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.044
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.044
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.044
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.098
RIN3 N/A 0.074 0.145
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.110
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.073 0.049
GABRR1 N/A 0.0727 0.049
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.098
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.071 0.057
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.071 0.067
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.071 0.071
CAPNS1 CAPNS1, CAPN4, CAPNS: Calpain small subunit 1 0.070 0.100
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.091
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.070 0.034
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.069 0.029
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.069 0.033
CDK6 CDK6: Cell division protein kinase 6 0.069 0.091
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.081
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.090
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.032
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.069 0.029
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.081
CDK4 CDK4: Cell division protein kinase 4 0.069 0.067
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.069 0.0818
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.033
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.086
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 46.80
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.111
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.063 0.081
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.063 0.033
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.063 0.028
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.063 0.064
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.063 0.041
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.063 0.051
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.026
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.063 0.067
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.063 0.035
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.033
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.063 0.064
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.090
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.113
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.062 0.037
MDM4 MDM4, MDMX: Mdm4 protein 0.062 0.025
COBL N/A 0.062 0.0453
SPTAN1 N/A 0.062 0.081
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.096
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.062 0.051
GRLF1 N/A 0.062 0.081
CHAT CHAT: Choline O-acetyltransferase 0.062 0.030
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.111
GLRA1 N/A 0.058 0.049
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.171
PFKFB2 PFKFB2: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.057 0.028
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.109
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.062
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.152
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.056 0.041
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.041
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.033
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.056 0.037
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.056 0.033
TERT TERT, EST2, TCS1, TRT: Telomerase reverse transcriptase 0.056 0.025
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 43.20
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.033
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.029
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.033
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.064
WEE1 WEE1: Wee1-like protein kinase 0.056 0.0453
SALF GTF2A1L, ALF, GTF2A1LF: TFIIA-alpha and beta-like factor 0.056 0.025
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.029
TP73 TP73, P73: Tumor protein p73 0.055 0.045
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.054 0.057
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.054 0.033
EIF4EBP1 EIF4EBP1: Eukaryotic translation initiation factor 4E-binding protein 1 0.053 0.034
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.053 0.030
FUBP1 N/A 0.052 0.057
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.032
MT1H N/A 0.051 0.051
PPP1R14C PPP1R14C, KEPI: Protein phosphatase 1 regulatory subunit 14C 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
GRB10 N/A 0.051 0.617
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
PTPRA N/A 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
RAPH1 N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
PPP1R1B PPP1R1B, DARPP32: Protein phosphatase 1 regulatory subunit 1B 0.051 0.051
EVL EVL, RNB6: Ena/VASP-like protein 0.051 0.051
C9orf88 N/A 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
CRK CRK: Proto-oncogene C-crk 0.051 0.617
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.051 0.072
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.049
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.040
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.064
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.050 0.029
CDKL5 N/A 0.049 0.032
KRT1 KRT1, KRTA: Keratin, type II cytoskeletal 1 0.049 0.030
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.165
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.083
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.165
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.165
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.083
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.165
EDA N/A 0.049 0.083
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.165
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.165
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.083
ATP2A3 ATP2A3: Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 0.049 0.083
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.083
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.165
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.165
DYRK3 N/A 0.049 0.033
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.033
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.049 0.035
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.064
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.048 0.051
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.047 0.044
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.047 0.062
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.046 0.028
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.046 0.027
DLG1 N/A 0.046 0.029
XPO1 XPO1, CRM1: Exportin-1 0.046 0.0818
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.033
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.046 0.051
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.046 0.041
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.049
TBC1D4 TBC1D4: TBC1D4 protein 0.046 0.051
PPP1R14A PPP1R14A, CPI17, PPP1INL: Protein phosphatase 1 regulatory subunit 14A 0.046 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.046 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.553
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.553
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.046 0.030
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.046 0.058
MT1X MT1X: Metallothionein-1X 0.046 0.072
MT2A MT2A, CES1, MT2: Metallothionein-2 0.046 0.072
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.152
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.049
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.098
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0453 0.034
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.0453 0.026
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.045 0.072
CGA CGA: Glycoprotein hormones alpha chain precursor 0.045 0.072
TSHB TSHB: Thyrotropin subunit beta precursor 0.045 0.072
FSHB FSHB: Follitropin subunit beta precursor 0.045 0.072
LHB LHB: Lutropin subunit beta precursor 0.045 0.072
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.045 0.072
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.191
MYO3A MYO3A: Myosin IIIA 0.044 0.029
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.041
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.026
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.033
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.044 0.029
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.072
CNN3 CNN3: Calponin-3 0.044 0.081
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.058
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.058
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.073
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.044 0.029
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.075
AQP4 AQP4: Aquaporin-4 0.044 0.047
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.075
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.047
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.025
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.075
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.025
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.148
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.043 0.057
AKR7A2 AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2 0.043 0.041
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.072
XRCC1 XRCC1: DNA-repair protein XRCC1 0.0425 0.031
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.042 0.034
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.041 0.043
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.041 0.073
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.073
MT1F MT1F, PRO0376: Metallothionein-1F 0.041 0.081
INHA INHA: Inhibin alpha chain precursor 0.041 0.072
FGF5 FGF5: Fibroblast growth factor 5 precursor 0.041 0.072
NDP NDP: Norrin precursor 0.041 0.081
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.041 0.072
LOC645745 MT1H: Metallothionein-1H 0.041 0.072
GLRB GLRB: Glycine receptor subunit beta precursor 0.041 0.056
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.275
SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 0.041 0.143
FGF9 FGF9: Glia-activating factor precursor 0.041 0.073
BMP7 BMP7, OP1: Bone morphogenetic protein 7 precursor 0.041 0.073
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.052
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.052
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.097
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.056
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.097
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.026
MYH9 MYH9: Myosin-9 0.038 0.041
GMFB GMFB: Glia maturation factor beta 0.038 0.033
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.038 0.033
CHP CHP: Calcium-binding protein p22 0.038 0.073
MDN1 MDN1, KIAA0301: Midasin 0.038 0.051
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.073
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.037 0.049
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.109
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.109
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.098
GHR GHR: Growth hormone receptor precursor 0.037 0.109
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.307
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.037 0.049
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.109
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.098
RAP1GA1 N/A 0.037 0.039
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.109
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.123
CRLF3 N/A 0.036 0.109
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.152
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.123
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.109
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.123
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.036 0.096
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.123
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.123
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.123
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.030
MT1E MT1E: Metallothionein-1E 0.034 0.0338
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.0338 0.038
MAL2 MAL2: Protein MAL2 0.034 0.034
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.109
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.033 0.0308
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.035
SCARB2 SCARB2, CD36L2, LIMPII: Lysosome membrane protein 2 0.033 0.056
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.035
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.0308
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.033 0.044
RHO RHO, OPN2: Rhodopsin 0.033 0.055
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.055
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.191
PRLR PRLR: Prolactin receptor precursor 0.033 0.109
F3 F3: Tissue factor precursor 0.032 0.109
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.032 0.026
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.123
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.109
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.109
ITGB4 N/A 0.032 0.109
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.062
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.065
IPO7 IPO7: Uncharacterized protein IPO7 0.032 0.202
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.032 0.0453
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.123
AP2M1 AP2M1, CLAPM1, KIAA0109: AP-2 complex subunit mu-1 0.032 0.028
RYR2 RYR2: Ryanodine receptor 2 0.031 0.063
PPP1R14D PPP1R14D, GBPI: Protein phosphatase 1 regulatory subunit 14D 0.031 0.030
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.030 0.0338
PPP1R1A PPP1R1A, IPP1: Protein phosphatase 1 regulatory subunit 1A 0.030 0.0338
GJA5 GJA5: Gap junction alpha-5 protein 0.030 0.0338
PEBP1 PEBP1, PBP, PEBP: Phosphatidylethanolamine-binding protein 1 0.030 0.042
SYNGR2 SYNGR2, UNQ352/PRO615: Synaptogyrin-2 0.030 0.030
C1QBP C1QBP, GC1QBP, HABP1, SF2P32: Complement component 1 Q subcomponent-binding prot 0.030 0.030
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 46.80
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.049
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.097
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.062
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.109
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.098
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.055
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.062
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.171
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.029 0.075
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.029 0.090
THOP1 THOP1: Thimet oligopeptidase 0.029 0.090
SYMPK SYMPK, SPK: Symplekin 0.029 0.051
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.029 0.033
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.029 0.027
KIAA0690 N/A 0.029 0.033
DSP DSP: Desmoplakin 0.028 0.04
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.028 0.04
SYTL4 Endocrine transmitter regulatory protein 0.028 0.034
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.109
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.109
PPEF1 N/A 0.028 0.109
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.04
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.028 0.073
VAV3 VAV3: Protein vav-3 0.028 0.179
MTM1 MTM1, CG2: Myotubularin 0.028 0.029
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.0308
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.217
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.217
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.217
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.217
LILRB1 N/A 0.027 0.109
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.123
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.152
CD69 CD69: Early activation antigen CD69 0.027 0.123
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.152
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.055
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.035
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.097
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.097
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.035
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.081
DBN1 DBN1, D0S117E: Drebrin 0.026 0.037
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.081
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.026 0.072
MT3 MT3: Metallothionein-3 0.026 0.062
SLC18A2 SLC18A2, SVMT, VMAT2: Synaptic vesicular amine transporter 0.0253 0.055
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.025 0.072
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.025 0.081
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.081
F5 F5: Coagulation factor V precursor 0.025 0.065
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.025 0.098
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.044
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.098
GSN GSN: Gelsolin precursor 0.025 0.036
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.025 0.098
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.030
MYO18A 0.025 0.049
COTL1 COTL1, CLP: Coactosin-like protein 0.025 0.04
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.044
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.0688
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.098
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.025 0.044
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.030
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.109
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.025 0.098
NIPBL N/A 0.025 0.044
CFL2 CFL2: Cofilin-2 0.025 0.036
SVIL SVIL: Supervillin 0.025 0.036
0.572
Total Score 9.29