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Evidence of Interaction Between MAPK1 and PTPN2

The interaction score between MAPK1 and PTPN2 is 11.60.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismMAPK1 OrthologuePTPN2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly P40417 1 Q9W0G1 0.27

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and PTPN2:
Domains in MAPK1Domains in PTPN2
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000242 Tyrosine specific protein phosphatase
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase
IPR012265 Tyr_Ptase_nr1_2.

The Chi square scores for co-occurrence of domains that are present in MAPK1 and PTPN2 are listed below.

Domain 1Domain 2Chi Square
IPR003527 MAP kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 128.642
IPR008349 ERK1/2 MAP kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 89.8437
IPR000719 Protein kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 14.0817
IPR002290 Serine/threonine protein kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 10.8808
IPR011009 Protein kinase-like IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 6.38835
IPR008271 Serine/threonine protein kinase, active site IPR000242 Tyrosine specific protein phosphatase 5.79901
IPR011009 Protein kinase-like IPR012265 Tyr_Ptase_nr1_2. 4.19561
IPR000719 Protein kinase IPR012265 Tyr_Ptase_nr1_2. 3.50984
IPR008271 Serine/threonine protein kinase, active site IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 2.56073
IPR000719 Protein kinase IPR000242 Tyrosine specific protein phosphatase 1.75342
IPR002290 Serine/threonine protein kinase IPR000242 Tyrosine specific protein phosphatase 1.72741
IPR008349 ERK1/2 MAP kinase IPR000242 Tyrosine specific protein phosphatase 1.64712
IPR011009 Protein kinase-like IPR000242 Tyrosine specific protein phosphatase 0.527708
IPR003527 MAP kinase IPR000242 Tyrosine specific protein phosphatase 0.182607

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in PTPN2
  • Green Domain is present in both MAPK1 and PTPN2

 0.109
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: PTPN2

PTMResidueReference
Phosphorylation 304 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: PTPN2

LocalisationReference
ER HPRD
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between MAPK1 and PTPN2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andPTPN2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and PTPN2 has 1137 interactors of which there are 550 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for PTPN2-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 46.90
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.030
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 94.70 0.030
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.044
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.044
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.030
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 10.50 0.025
CDK2 CDK2: Cell division protein kinase 2 6.80 0.098
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 2.53 0.025
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.044
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 2.02 0.098
GNAI2 Galphai2 protein 1.71 0.025
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 1.42 0.044
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 1.03 0.025
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.034
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 0.025
PLEK PLEK, P47: Pleckstrin 0.515 0.034
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.509 0.025
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.044
CRKL CRKL: Crk-like protein 0.461 0.098
JAK1 0.461 0.098
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.044
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.044
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.098
MSN MSN: Moesin 0.461 0.098
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.098
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.036
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.456 0.025
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.449 0.025
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.109
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.0688
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 0.405 0.025
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.098
STK10 STK10: Uncharacterized protein STK10 0.385 0.098
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.036
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.062
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 46.90
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.044
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.044
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.109
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.098
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.098
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 46.90
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.098
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.098
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.098
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.044
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.049
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.109
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.109
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.109
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.04
DOK1 DOK1: Docking protein 1 0.275 0.098
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.098
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.062
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.098
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.098
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.098
HCK N/A 0.275 0.098
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.098
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.098
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.049
GAB2 N/A 0.251 0.049
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.109
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.049
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.109
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.044
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.098
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.098
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.098
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.098
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.098
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.044
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 112.00
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.0688
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.098
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.044
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.098
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.044
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.062
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.225 0.062
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.109
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.109
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.109
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.049
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.109
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.0688
CXorf9 N/A 0.188 0.098
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.044
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.098
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.098
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.098
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.098
RPS6KB1 N/A 0.188 0.098
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.098
FNBP1 N/A 0.188 0.044
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.098
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 46.90
PSD TYL: TYL protein 0.171 0.044
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.044
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.036
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.044
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.098
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.109
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.049
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.049
PSCD2 N/A 0.165 0.049
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.109
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.109
MAP2K5 N/A 0.165 0.109
NF2 NF2, SCH: Merlin 0.165 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.049
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.109
HD HD, IT15: Huntingtin 0.155 0.049
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.109
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.109
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.109
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.165
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.109
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.049
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.109
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.109
ETS2 ETS2: Protein C-ets-2 0.152 0.0688
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.098
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.098
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.109
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.098
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.098
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.098
STAT3 0.148 0.109
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.098
ELMO1 N/A 0.148 0.044
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.044
ARHGEF7 N/A 0.148 0.044
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.044
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.098
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 29.60
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.098
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.146 0.044
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.139 0.062
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.098
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.098
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.098
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.098
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.098
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.098
ATM ATM: Serine-protein kinase ATM 0.139 0.098
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.044
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.098
CD2AP CD2AP: CD2-associated protein 0.139 0.044
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.148
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.098
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.098
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.044
RDX RDX: Radixin 0.136 0.098
VIL2 N/A 0.136 0.098
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.098
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.098
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.136 0.030
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.034
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.127 0.109
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.109
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.109
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.109
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.109
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.124 0.028
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.083
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.109
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.109
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.114 0.098
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.044
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.098
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.036
CDK5 CDK5: Cell division protein kinase 5 0.114 0.098
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.114 0.030
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.098
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.098
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.114 0.098
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.098
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.098
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.036
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.109
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.098
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.098
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.098
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.098
PLD2 PLD2: Phospholipase D2 0.111 0.044
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.109
BMX N/A 0.110 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.083
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.049
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.049
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.034
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.0688
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.098
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.109
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.083
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.025
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.098
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.098
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.062
PLD1 PLD1: Phospholipase D1 0.097 0.044
DAB1 DAB1: Disabled homolog 1 0.097 0.036
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.044
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.036
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.098
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.096 0.109
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.096 0.0688
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.049
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.109
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.109
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.049
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.083
CD44 N/A 0.091 0.028
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.025
PTPRZ1 N/A 0.090 0.148
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.098
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.044
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.086 0.098
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.098
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.098
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.148
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.098
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.086 0.098
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.098
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.109
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.098
TP53 TP53, P53: Cellular tumor antigen p53 0.086 0.062
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.086 0.098
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.109
MAPKAPK5 N/A 0.083 0.109
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.049
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.109
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.109
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.049
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.109
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.109
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.109
MAPK15 N/A 0.083 0.109
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.109
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.109
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.109
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.025
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.148
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.044
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.078 0.036
LCP1 LCP1, PLS2: Plastin-2 0.078 0.044
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.109
PRKAA1 N/A 0.077 0.109
LIMK2 LIMK2: LIM domain kinase 2 0.077 0.109
STK16 N/A 0.077 0.109
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.083
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.109
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.109
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.049
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.075 0.028
ATP2B1 N/A 0.075 0.028
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.165
FADD FADD, MORT1: Protein FADD 0.075 0.028
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.098
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.044
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.075 0.062
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.062
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.044
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.098
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.049
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.109
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.098
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.098
CNN2 CNN2: Calponin-2 0.075 0.04
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.098
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.062
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.044
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.148
TSC2 TSC2, TSC4: Tuberin 0.075 0.044
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.098
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.109
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.098
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.044
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.098
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.098
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.098
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.098
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.075 0.098
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.098
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.109
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.098
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.109
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.109
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.044
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.075
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.073 0.025
GABRR1 N/A 0.0727 0.028
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.165
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.071 0.036
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.069 0.098
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.069 0.098
CDK6 CDK6: Cell division protein kinase 6 0.069 0.098
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.098
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.069 0.098
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.098
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.069 0.098
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.098
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.069 0.098
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.069 0.098
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.098
CDK4 CDK4: Cell division protein kinase 4 0.069 0.098
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.098
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.148
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 71.20
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.148
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.063 0.044
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.063 0.044
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.063 0.036
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.148
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.063 0.040
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.063 0.030
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.063 0.044
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.044
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.044
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.062 0.109
SPTAN1 N/A 0.062 0.049
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.165
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.148
GLRA1 N/A 0.058 0.025
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.148
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.028
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.057 0.028
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.028
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.165
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.098
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.098
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.056 0.098
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.098
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.109
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.098
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.109
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.056 0.098
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.044
WEE1 WEE1: Wee1-like protein kinase 0.056 0.098
PRKCB1 PRKCB1, PKCB, PRKCB: Protein kinase C beta type 0.055 0.051
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.109
TP73 TP73, P73: Tumor protein p73 0.055 0.0688
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.049
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
GRB10 N/A 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.051 0.165
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.025
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.036
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.050 0.098
CDKL5 N/A 0.049 0.109
DAPK2 DAPK2: Death-associated protein kinase 2 0.049 0.109
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.028
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.028
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.028
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.028
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.165
EDA N/A 0.049 0.028
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.083
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.028
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.028
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.165
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.165
DYRK3 N/A 0.049 0.098
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.098
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.044
DLG1 N/A 0.046 0.025
XPO1 XPO1, CRM1: Exportin-1 0.046 0.044
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.046 0.044
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.046 0.098
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.046 0.044
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.028
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.046
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.0453 0.028
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.165
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.028
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.165
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0453 0.028
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.0453 0.028
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.028
MYO3A MYO3A: Myosin IIIA 0.044 0.098
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.098
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.098
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.109
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.044 0.098
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.049
CNN3 CNN3: Calponin-3 0.044 0.04
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.098
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.044
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.098
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.044 46.90
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.025
AQP4 AQP4: Aquaporin-4 0.044 0.025
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.025
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.075
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.148
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.025
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.025
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.025
TXN TXN, TRDX, TRX, TRX1: Thioredoxin 0.043 0.044
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.049
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.0425 0.049
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.041 0.025
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.148
GLRB GLRB: Glycine receptor subunit beta precursor 0.041 0.025
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.165
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 0.047
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.028
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.028
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.075
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.025
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.025
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.098
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.040 0.098
MYH9 MYH9: Myosin-9 0.038 0.030
GMFB GMFB: Glia maturation factor beta 0.038 0.098
CFL1 CFL1, CFL: Cofilin-1 0.038 0.098
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.038 0.044
CHP CHP: Calcium-binding protein p22 0.038 0.044
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.098
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.038 0.044
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.037 0.028
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.165
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.083
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.028
GHR GHR: Growth hormone receptor precursor 0.037 0.165
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.165
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.037 0.028
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.165
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.165
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.165
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.165
CRLF3 N/A 0.036 0.165
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.165
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.165
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.165
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.165
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.036 0.028
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.165
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.165
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.083
TXNDC TXNDC1, TMX, PSEC0085, TXNDC, UNQ235/PRO268: Thioredoxin domain-containing prote 0.035 0.030
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.051
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.109
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.033 0.025
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.075
SCARB2 SCARB2, CD36L2, LIMPII: Lysosome membrane protein 2 0.033 0.025
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.075
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.052
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.075
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.033 0.148
RHO RHO, OPN2: Rhodopsin 0.033 0.028
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.028
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.165
PRLR PRLR: Prolactin receptor precursor 0.033 0.165
F3 F3: Tissue factor precursor 0.032 0.083
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.032 0.028
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.028
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.165
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.028
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.052
ITGB4 N/A 0.032 0.165
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.028
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.049
IPO7 IPO7: Uncharacterized protein IPO7 0.032 0.049
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.032 0.025
NCSTN NCSTN, KIAA0253, UNQ1874/PRO4317: Nicastrin precursor 0.032 0.025
VDP DKFZp451D234: Putative uncharacterized protein DKFZp451D234 0.032 0.062
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.165
RYR2 RYR2: Ryanodine receptor 2 0.031 0.034
RRAS RRAS: Ras-related protein R-Ras precursor 0.0308 6.17
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.148
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.148
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.148
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.028
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.083
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.028
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.028
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.028
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.148
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.148
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.029 0.036
GSTP1 GSTP1, FAEES3, GST3: Glutathione S-transferase P 0.029 0.049
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.029 0.044
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.029 0.098
PRDX6 PRDX6, AOP2, KIAA0106: Peroxiredoxin-6 0.029 0.044
SYMPK SYMPK, SPK: Symplekin 0.029 0.044
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.029 0.098
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.029 0.044
KIAA0690 N/A 0.029 0.044
DSP DSP: Desmoplakin 0.028 0.049
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.028 0.109
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.049
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.049
PPEF1 N/A 0.028 0.049
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.109
PKP4 PKP4: Plakophilin-4 0.028 0.109
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.025
SLC2A1 SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1 0.027 0.025
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
LILRB1 N/A 0.027 0.165
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.165
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.027 0.028
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.165
CD69 CD69: Early activation antigen CD69 0.027 0.083
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.028
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.028
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.148
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.148
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.148
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.075
PDIA3 PDIA3, ERP57, ERP60, GRP58: Protein disulfide-isomerase A3 precursor 0.026 0.030
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.026 0.028
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.109
DBN1 DBN1, D0S117E: Drebrin 0.026 0.109
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.049
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.026 0.049
TNIK TNIK, KIAA0551: TRAF2 and NCK-interacting protein kinase 0.0253 0.051
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.109
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.025 0.049
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.025 0.044
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.030
COTL1 COTL1, CLP: Coactosin-like protein 0.025 0.098
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.030
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.044
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.044
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.062
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.044
NIPBL N/A 0.025 0.044
CFL2 CFL2: Cofilin-2 0.025 0.098
0.299
Total Score 11.60