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Evidence of Interaction Between MAPK1 and MYL9

The interaction score between MAPK1 and MYL9 is 1.23.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and MYL9 = -0.25

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.65E-3
Orthology
OrganismMAPK1 OrthologueMYL9 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 Q09510 0.755
  • Y2H

Get References From PubMed
fly P40417 1 P40423 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.191
Domains Domains present in MAPK1 and MYL9:
Domains in MAPK1Domains in MYL9
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR002048 Calcium-binding EF-hand
IPR011992 EF-Hand_type.

The Chi square scores for co-occurrence of domains that are present in MAPK1 and MYL9 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR002048 Calcium-binding EF-hand 25.8227
IPR008271 Serine/threonine protein kinase, active site IPR011992 EF-Hand_type. 18.67
IPR011009 Protein kinase-like IPR002048 Calcium-binding EF-hand 18.3805
IPR000719 Protein kinase IPR011992 EF-Hand_type. 15.5567
IPR008271 Serine/threonine protein kinase, active site IPR002048 Calcium-binding EF-hand 10.816
IPR002290 Serine/threonine protein kinase IPR011992 EF-Hand_type. 9.84625
IPR011009 Protein kinase-like IPR011992 EF-Hand_type. 9.34155
IPR002290 Serine/threonine protein kinase IPR002048 Calcium-binding EF-hand 6.27248

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in MYL9
  • Green Domain is present in both MAPK1 and MYL9

 0.028
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: MYL9

PTMResidueReference
Phosphoserine 19 PubMed, HPRD
Phosphothreonine 18 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: MYL9

No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between MAPK1 and MYL9 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andMYL9. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and MYL9 has 552 interactors of which there are 412 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for MYL9-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 3.51
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.025
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.050
CRKL CRKL: Crk-like protein 0.461 0.031
JAK1 0.461 0.088
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.088
MSN MSN: Moesin 0.461 0.049
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.088
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.044
ID2 ID2: DNA-binding protein inhibitor ID-2 0.430 0.0263
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.031
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.088
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.0308
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.088
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.088
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.028
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.088
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.088
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.088
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.088
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.099
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.055
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.099
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.069
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.044
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.097
HCK N/A 0.275 0.097
ETS1 ETS1, EWSR2: Protein C-ets-1 0.275 0.029
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.088
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.086
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.098
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.233 0.058
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.044
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.0308
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.028
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.055
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.031
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.188 0.056
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.056
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.044
RPS6KB1 N/A 0.188 0.044
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.0308
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 22.50
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.035
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.029
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.083
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.028
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.083
PSCD2 N/A 0.165 0.028
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.056
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.028
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.056
NF2 NF2, SCH: Merlin 0.165 0.083
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.028
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.052
ARFGAP1 N/A 0.155 0.032
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.049
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.032
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.251
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.123
ETS2 ETS2: Protein C-ets-2 0.152 0.037
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.025
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.025
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.047
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.047
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.148
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.025
ELMO1 N/A 0.148 0.025
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.075
ARHGEF7 N/A 0.148 0.025
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.148
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.075
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.036
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.148
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.075
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.146 0.044
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.146 0.044
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.044
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.044
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.098
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.044
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.028
RDX RDX: Radixin 0.136 0.056
VIL2 N/A 0.136 0.049
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.044
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.044
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.132 0.062
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.055
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.127 0.0263
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.049
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.029
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.031
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.123 0.055
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.096
NRAS NRAS, HRAS1: GTPase NRas precursor 0.118 0.044
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.028
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.050
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.111
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.029
EDD1 EDD1, EDD, HYD, KIAA0896: E3 ubiquitin-protein ligase EDD1 0.113 0.029
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.056
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.111
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.028
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.029
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.088
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.109
BMX N/A 0.110 0.098
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.032
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.030
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.109
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.032
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.044
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.049
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.098
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.044
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.097
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.044
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.056
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.123
NFATC1 N/A 0.096 0.032
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.029
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.097
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.114
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.044
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.069
RELA RELA, NFKB3: Transcription factor p65 0.086 0.041
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.114
AHR AHR: Aryl hydrocarbon receptor precursor 0.086 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.028
MAPKAPK5 N/A 0.083 0.028
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.028
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.052
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.028
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.049
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.083 0.04
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.028
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.028
MAPK15 N/A 0.083 0.083
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.049
CASP9 CASP9, MCH6: Caspase-9 precursor 0.083 0.028
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.083 0.028
HES6 HES6: Transcription cofactor HES-6 0.083 0.04
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.028
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.083 0.028
IRF3 IRF3: Interferon regulatory factor 3 0.080 0.032
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.029
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.078 0.0296
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.078 0.026
LCP1 LCP1, PLS2: Plastin-2 0.078 0.088
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.078 0.026
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.049
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.062
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.031
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.055
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.032
MAX MAX: Protein max 0.075 0.036
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.075 0.036
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.025
GIT2 N/A 0.075 0.075
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.025
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.044
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.075
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.025
SNX3 N/A 0.075 0.025
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.025
CNN2 CNN2: Calponin-2 0.075 0.165
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.025
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.075 0.036
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.025
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.025
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.075 0.036
TSC2 TSC2, TSC4: Tuberin 0.075 0.025
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.148
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.025
TFAP4 TFAP4: Transcription factor AP-4 0.075 0.036
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.025
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.075
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.025
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.025
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.028
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.075
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.033
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.070 0.033
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.070 0.049
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.069 0.056
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.069 0.056
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.044
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.069
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.069
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.073
ACTG1 ACTB: Actin, cytoplasmic 1 0.063 0.049
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.063 0.044
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.063 0.044
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.063 0.033
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.063 0.097
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.063 0.049
EXOC2 N/A 0.063 0.031
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.040
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.050
SPTAN1 N/A 0.062 0.055
VIM VIM: Vimentin 0.060 0.0453
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.041
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.028
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.033
ESRRA ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1 0.056 0.027
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.0308
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.0308
NOS1 NOS1: Nitric-oxide synthase, brain 0.056 0.044
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.062
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.052 0.055
LIMS1 N/A 0.052 0.062
DDX21 DDX21: Nucleolar RNA helicase 2 0.052 0.029
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.052 0.026
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.251
HES1 HES1, HL, HRY: Transcription factor HES-1 0.050 0.033
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.763
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.049 0.061
KRT1 KRT1, KRTA: Keratin, type II cytoskeletal 1 0.049 0.034
DAPK2 DAPK2: Death-associated protein kinase 2 0.049 0.032
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.049
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.049
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.109
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.109
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.109
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.049
MYF5 MYF5: Myogenic factor 5 0.049 0.029
RAB5B RAB5B: Ras-related protein Rab-5B 0.047 0.075
LMNA LMNA, LMN1: Lamin-A/C 0.047 0.036
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.046 0.026
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.046 0.040
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.046 0.044
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.046 0.026
LPXN LPXN, LDLP: Leupaxin 0.046 0.044
COPE COPE: Coatomer subunit epsilon 0.046 0.029
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.046 0.050
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.046 0.029
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.046 0.029
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.029
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.032
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.032
MYO3A MYO3A: Myosin IIIA 0.044 0.111
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.054
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.044
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.038
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.032
CNN3 CNN3: Calponin-3 0.044 0.251
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.029
HAND1 HAND1, EHAND: Heart- and neural crest derivatives-expressed protein 1 0.044 0.033
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.098
AKR7A2 AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2 0.043 0.029
MPG N/A 0.0425 0.026
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.098
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.0425 0.026
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.056
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.064
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.058
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 0.029
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.026
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.026
NEF3 NEFM, NEF3, NFM: Neurofilament medium polypeptide 0.039 0.049
GFAP GFAP: Glial fibrillary acidic protein 0.039 0.049
KCTD12 KCTD12, C13orf2, KIAA1778, PFET1: BTB/POZ domain-containing protein KCTD12 0.038 0.033
MYH9 MYH9: Myosin-9 0.038 0.073
RANBP9 RANBP9, RANBPM: Ran-binding protein 9 0.038 0.026
CREBBP CREBBP, CBP: CREB-binding protein 0.038 0.033
MDN1 MDN1, KIAA0301: Midasin 0.038 0.028
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.069
GHR GHR: Growth hormone receptor precursor 0.037 0.037
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.032
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.029
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.032
RAP1GA1 N/A 0.037 0.032
CRLF3 N/A 0.036 0.033
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.029
KRT20 KRT20: Keratin, type I cytoskeletal 20 0.034 0.0263
NEFH NEFH, KIAA0845, NFH: Neurofilament heavy polypeptide 0.034 0.048
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.029
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.026
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.026
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.029
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.037
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.0453
PRLR PRLR: Prolactin receptor precursor 0.033 0.029
F3 F3: Tissue factor precursor 0.032 0.032
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.032
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.037
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.123
ZYX ZYX: Zyxin 0.032 0.077
AP2M1 AP2M1, CLAPM1, KIAA0109: AP-2 complex subunit mu-1 0.032 0.033
RYR2 RYR2: Ryanodine receptor 2 0.031 0.051
KRT18 KRT18: Uncharacterized protein KRT18 0.031 0.030
DES DES: Desmin 0.031 0.260
RRAS RRAS: Ras-related protein R-Ras precursor 0.0308 0.188
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.148
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.148
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.030
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.065
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.113
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.064
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.029 0.097
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.029 0.049
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.029 0.049
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.029 0.056
AIP AIP, XAP2: AH receptor-interacting protein 0.029 0.056
RGS18 RGS18, RGS13: Regulator of G-protein signaling 18 0.028 0.083
DSP DSP: Desmoplakin 0.028 0.049
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
SH2D3A SH2D3A, NSP1, UNQ175/PRO201: SH2 domain-containing protein 3A 0.028 0.028
AHSA2 AHSA2, DKFZp564C236, hCG_15158: Putative uncharacterized protein DKFZp564C236 0.028 0.028
CACNB2 N/A 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
PTPN7 N/A 0.028 0.028
STAP2 Uncharacterized protein ENSP00000317912 0.028 0.028
CDC42 N/A 0.028 0.028
PDE5A PDE5A, PDE5: cGMP-specific 3',5'-cyclic phosphodiesterase 0.028 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.165
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.056
AXIN1 0.028 0.083
MATK 0.028 0.028
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.044
PHLDB2 N/A 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
YWHAG YWHAG: 14-3-3 protein gamma 0.028 0.028
ABLIM1 ABLIM1, RP11-317F20.1-001: Actin binding LIM protein 1 0.028 0.028
PPEF1 N/A 0.028 0.165
LNX1 N/A 0.028 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.028
C9orf88 N/A 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
CASP6 CASP6, MCH2: Caspase-6 precursor 0.028 0.028
NCF4 N/A 0.028 0.028
SLC9A3R2 SLC9A3R2: SLC9A3R2 protein (Fragment) 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
PKP4 PKP4: Plakophilin-4 0.028 0.028
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.028 0.083
RRAD RRAD, RAD: GTP-binding protein RAD 0.028 0.029
PRPH PRPH, NEF4, PRPH1: Peripherin 0.0277 0.062
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
RASGRF1 RASGRF1, CDC25: Guanine nucleotide-releasing protein 0.027 0.027
RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 0.027 0.027
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.029
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.026
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.026
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.029
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.191
KIF22 KIF22, KID, KNSL4: Kinesin-like protein KIF22 0.026 0.037
LMO6 LMO6: LIM domain only protein 6 0.025 0.075
RAD50 RAD50: DNA repair protein RAD50 0.025 0.025
SCRIB N/A 0.025 0.025
UBE2R2 UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2 0.025 0.025
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.075
WRNIP1 WRNIP1, WHIP: ATPase WRNIP1 0.025 0.028
BCR N/A 0.025 0.025
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.025
GSN GSN: Gelsolin precursor 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
MYO18A 0.025 0.148
COTL1 COTL1, CLP: Coactosin-like protein 0.025 0.025
EPN2 N/A 0.025 0.025
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.075
NCOA5 NCOA5, KIAA1637: Nuclear receptor coactivator 5 0.025 0.025
G3BP2 G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.047
SH3PX3 SH3PX3, DKFZp666B159, hCG_1731072: SH3 and PX domain-containing protein 3. 0.025 0.025
DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 0.025 0.025
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.044
SPAST SPAST, KIAA1083, SPG4: Spastin 0.025 0.025
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.050
DCTN1 DCTN1: Dynactin subunit 1 0.025 0.025
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.044
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
BCOR N/A 0.025 0.025
MAP2K3 N/A 0.025 0.025
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.025 0.075
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.025 0.025
GRK6 N/A 0.025 0.025
RASD1 RASD1, AGS1, DEXRAS1: Dexamethasone-induced Ras-related protein 1 precursor 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.025
PRKCB1 N/A 0.025 0.025
HSPA8 HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.025 0.044
RAC1 N/A 0.025 0.025
DBNL N/A 0.025 0.025
CAMK2A N/A 0.025 0.025
RSN CLIP1, CYLN1, RSN: CAP-Gly domain-containing linker protein 1 0.025 0.025
CFL2 CFL2: Cofilin-2 0.025 0.025
SVIL SVIL: Supervillin 0.025 0.025
CAMKK1 N/A 0.025 0.025
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.025 0.025
CHTF18 RUVBL, CHTF18: Protein CTF18 homolog. 0.025 0.025
PDE4B PDE4B, DPDE4: cAMP-specific 3',5'-cyclic phosphodiesterase 4B 0.025 0.025
2.15E-3
Total Score 1.23