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Evidence of Interaction Between MAPK1 and ACVR1B

The interaction score between MAPK1 and ACVR1B is 4.01.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismMAPK1 OrthologueACVR1B OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 P20792 0.57
fly P40417 1 Q8MKS1 0.313

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and ACVR1B:
Domains in MAPK1Domains in ACVR1B
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000719 Protein kinase
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR008271 Serine/threonine protein kinase, active site

The Chi square scores for co-occurrence of domains that are present in MAPK1 and ACVR1B are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR000719 Protein kinase 30.6895
IPR003527 MAP kinase IPR008271 Serine/threonine protein kinase, active site 20.8159
IPR008349 ERK1/2 MAP kinase IPR008271 Serine/threonine protein kinase, active site 17.555
IPR002290 Serine/threonine protein kinase IPR008271 Serine/threonine protein kinase, active site 8.88805
IPR000719 Protein kinase IPR008271 Serine/threonine protein kinase, active site 6.25263
IPR008271 Serine/threonine protein kinase, active site IPR008271 Serine/threonine protein kinase, active site 5.82656
IPR008349 ERK1/2 MAP kinase IPR000719 Protein kinase 4.26499
IPR011009 Protein kinase-like IPR000719 Protein kinase 2.94434
IPR003527 MAP kinase IPR000719 Protein kinase 2.81413
IPR011009 Protein kinase-like IPR008271 Serine/threonine protein kinase, active site 2.11823
IPR002290 Serine/threonine protein kinase IPR000719 Protein kinase 0.986464
IPR008271 Serine/threonine protein kinase, active site IPR000472 TGF-beta receptor/activin receptor, type I/II 0.960112
IPR000719 Protein kinase IPR000472 TGF-beta receptor/activin receptor, type I/II 0.743605
IPR011009 Protein kinase-like IPR000472 TGF-beta receptor/activin receptor, type I/II 0.26297

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in ACVR1B
  • Green Domain is present in both MAPK1 and ACVR1B

 0.049
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: ACVR1B

PTMResidueReference
Phosphorylation 380 PubMed, HPRD
Phosphotyrosine 380 HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: ACVR1B

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between MAPK1 and ACVR1B that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andACVR1B. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and ACVR1B has 1029 interactors of which there are 640 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for ACVR1B-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.044
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.062
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 94.70 0.062
DUSP21 DUSP21, LMWDSP21: Dual specificity protein phosphatase 21 72.50 5.11
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.098
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.062
DUSP14 DUSP14, MKP6: Dual specificity protein phosphatase 14 46.80 5.11
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 10.50 0.025
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 7.38 0.030
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.044
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 3.35 0.036
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 2.53 0.025
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.098
GNAI2 Galphai2 protein 1.71 0.025
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 1.03 0.025
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.0688
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 0.025
PLEK PLEK, P47: Pleckstrin 0.515 0.0688
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.509 0.025
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.098
CRKL CRKL: Crk-like protein 0.461 0.098
JAK1 0.461 0.098
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.098
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.098
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.098
MSN MSN: Moesin 0.461 0.098
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.098
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.098
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.456 0.025
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.449 0.025
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.109
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.0688
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 0.405 0.025
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.044
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.062
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.098
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.098
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.372 0.062
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.098
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.098
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.098
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.098
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.098
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.098
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.372 0.098
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.372 0.030
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.044
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.098
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.098
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.098
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.344 0.030
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.109
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.109
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.109
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.109
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.109
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.307 0.0688
DOK1 DOK1: Docking protein 1 0.275 0.098
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.098
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.062
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.098
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.098
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.098
HCK N/A 0.275 0.098
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.275 0.098
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.098
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.044
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.275 0.098
GAB2 N/A 0.251 0.109
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.109
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.251 0.0688
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.109
BACH1 BACH1: Transcription regulator protein BACH1 0.251 0.034
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.109
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.233 0.030
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.233 0.030
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.044
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.233 0.044
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.044
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.233 29.60
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.225 0.098
SH3BP5 N/A 0.225 0.098
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.098
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.062
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.098
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.098
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.098
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.098
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.062
CCNH CCNH: Cyclin-H 0.225 0.030
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.049
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.210 0.049
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.049
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.192 422.00
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.109
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.109
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.0688
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.188 0.098
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.044
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.188 0.030
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 6.17
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.188 0.030
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.098
GMIP GMIP: GEM-interacting protein 0.188 0.098
SEC24B SEC24B: Protein transport protein Sec24B 0.188 0.044
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.174 0.096
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.098
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.098
PSD TYL: TYL protein 0.171 0.098
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 46.90
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.098
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.098
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.098
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.062
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.109
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PSCD2 N/A 0.165 0.109
NSBP1 NSBP1: Nucleosome-binding protein 1 0.165 0.0688
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.109
BID BID: BH3-interacting domain death agonist 0.165 0.034
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.109
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.109
MAP2K5 N/A 0.165 0.109
NF2 NF2, SCH: Merlin 0.165 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.109
H1FX H1FX: Histone H1x 0.155 0.034
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.155 0.049
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.049
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.083
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.109
ERF ERF: ETS domain-containing transcription factor ERF 0.152 0.034
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.109
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.109
SNCB SNCB: Beta-synuclein 0.152 0.109
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.109
CREB1 CREB1: cAMP response element-binding protein 0.148 0.062
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.098
CCNT2 CCNT2: Cyclin-T2 0.148 0.030
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.098
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.098
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.098
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.098
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.030
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.098
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.098
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.098
STAT3 0.148 0.098
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.098
ELMO1 N/A 0.148 0.098
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.098
ARHGEF7 N/A 0.148 46.90
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.098
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.030
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.062
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.098
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.098
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.146 0.036
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.146 0.098
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.146 0.098
DUSP13 DUSP13, TMDP: Dual specificity protein phosphatase 13 0.141 5.11
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.139 0.030
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.139 0.030
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.139 0.044
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.044
CDKN1B CDKN1B, KIP1: Cyclin-dependent kinase inhibitor 1B 0.139 0.030
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.139 0.030
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.044
ATM ATM: Serine-protein kinase ATM 0.139 0.036
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.044
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.025
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.139 0.030
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.044
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.139 0.030
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.098
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.098
RDX RDX: Radixin 0.136 0.098
VIL2 N/A 0.136 0.098
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.098
CCNB1 Cyclin B1 0.136 0.030
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.098
STMN1 STMN1, LAP18, OP18: Stathmin 0.136 0.098
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.136 0.062
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.132 0.109
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.129 0.036
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.0688
RB1 RB1: Retinoblastoma-associated protein 0.127 0.034
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.04
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.127 0.049
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.049
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.124 0.028
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.083
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.109
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.109
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.123 0.049
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.109
NRAS NRAS, HRAS1: GTPase NRas precursor 0.118 0.098
CDC37 CDC37: Hsp90 co-chaperone Cdc37 0.116 0.046
PGAM1 PGAM1, PGAMA, CDABP0006: Phosphoglycerate mutase 1 0.114 0.062
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.044
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.044
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.114 0.030
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.044
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.114 0.030
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.114 0.030
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.044
RPS10 RPS10: 40S ribosomal protein S10 0.114 0.044
THOC1 THOC1, HPR1: THO complex subunit 1 0.114 0.044
EDD1 EDD1, EDD, HYD, KIAA0896: E3 ubiquitin-protein ligase EDD1 0.113 0.030
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.111 0.030
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.098
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.098
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.098
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.098
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.098
STMN2 STMN2, SCG10, SCGN10: Stathmin-2 0.111 0.098
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.098
PLD2 PLD2: Phospholipase D2 0.111 0.098
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.109
BMX N/A 0.110 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.109 0.109
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.109
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.109
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.0688
HMGA2 HMGA2, HMGIC: High mobility group protein HMGI-C 0.109 0.034
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.0688
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.098
ETV1 ETV1, ER81: ETS translocation variant 1 0.098 0.034
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.109
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.109
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.148
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.165
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.148
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.098
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.098
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.062
PLD1 PLD1: Phospholipase D1 0.097 0.098
DAB1 DAB1: Disabled homolog 1 0.097 46.90
TST TST: Thiosulfate sulfurtransferase 0.097 0.098
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.098
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.098
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.098
NBN NBN, NBS, NBS1, P95: Nibrin 0.0971 0.034
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.049
NFATC1 N/A 0.096 0.034
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.096 0.049
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.096 0.034
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.049
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.04
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.049
SMAD7 SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7 0.096 0.0688
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.096 0.034
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.109
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.083
CD44 N/A 0.091 0.083
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.047
PTPRZ1 N/A 0.090 0.148
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.088 0.030
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 46.90
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.098
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.044
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.025
CTPS CTPS: CTP synthase 1 0.086 0.044
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.086 29.60
RELA RELA, NFKB3: Transcription factor p65 0.086 0.030
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.044
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.086 0.044
CDK5R1 CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor 0.086 0.030
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 0.086 0.062
NPM1 NPM1, NPM: Nucleophosmin 0.086 0.030
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.044
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.086 0.044
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.049
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.049
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.034
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.049
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.04
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.049
MAPK15 N/A 0.083 0.049
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.034
CASP9 CASP9, MCH6: Caspase-9 precursor 0.083 0.049
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.083 0.049
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.083 0.04
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.025
IRF3 IRF3: Interferon regulatory factor 3 0.080 0.034
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.148
KIAA1012 KIAA1012: Protein TRS85 homolog 0.078 0.036
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.078 0.044
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.078 14.50
MYB MYB: Myb proto-oncogene protein 0.077 0.034
TSPYL2 TSPYL2, CDA1, HRIHFB2216, DENTT, TSPX: Testis-specific Y-encoded-like protein 2 0.077 0.034
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.028
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.049
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.075 0.028
ATP2B1 N/A 0.075 0.052
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.083
FADD FADD, MORT1: Protein FADD 0.075 0.083
GIT2 N/A 0.075 0.036
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.030
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.044
SNX3 N/A 0.075 0.098
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.044
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.075 0.044
CNN2 CNN2: Calponin-2 0.075 0.049
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.030
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.030
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.025
TSC2 TSC2, TSC4: Tuberin 0.075 0.044
RBL1 RBL1: Retinoblastoma-like protein 1 0.075 0.030
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.044
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.044
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.075 0.062
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.044
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.148
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.073 0.148
GABRR1 N/A 0.0727 0.165
CDC42 CDC42: Cell division control protein 42 homolog precursor 0.073 0.044
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.165
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.071 0.098
WDR1 N/A 0.070 0.034
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.070 0.046
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.044
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.098
CDC20 CDC20: Cell division cycle protein 20 homolog 0.069 0.030
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.069 0.036
CDK4 CDK4: Cell division protein kinase 4 0.069 6.17
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.069 0.044
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.044
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.075
BCL2L1 BCL2L1, BCL2L, BCLX: Apoptosis regulator Bcl-X 0.0688 0.034
MCL1 MCL1: Induced myeloid leukemia cell differentiation protein Mcl-1 0.0688 0.034
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.025
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.148
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.063 0.109
BCL2 BCL2: Apoptosis regulator Bcl-2 0.063 0.034
COPA COPA: Coatomer subunit alpha 0.063 0.044
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.063 0.030
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.063 0.044
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.063 0.044
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.063 0.098
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.025
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.063 0.030
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.062 0.049
MDM4 MDM4, MDMX: Mdm4 protein 0.062 0.034
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.028
GRLF1 N/A 0.062 0.109
CHAT CHAT: Choline O-acetyltransferase 0.062 0.030
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.148
GLRA1 N/A 0.058 0.148
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.148
PFKFB2 PFKFB2: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.057 0.062
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.083
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.057 0.028
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.083
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.083
HADHB HADHB, MSTP029: Trifunctional enzyme subunit beta, mitochondrial precursor 0.056 0.030
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.056 0.044
CASP2 CASP2, ICH1, NEDD2: Caspase-2 precursor 0.056 0.044
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.056 0.044
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.056 6.17
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.044
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.044
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.044
SALF GTF2A1L, ALF, GTF2A1LF: TFIIA-alpha and beta-like factor 0.056 0.034
NOS1 NOS1: Nitric-oxide synthase, brain 0.056 0.036
CDKN1A CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi 0.055 0.034
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.054 0.029
EIF4EBP1 EIF4EBP1: Eukaryotic translation initiation factor 4E-binding protein 1 0.053 0.046
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.053 0.046
RAB4A N/A 0.052 0.0688
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.052 0.049
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.051 0.051
PPP1R14C PPP1R14C, KEPI: Protein phosphatase 1 regulatory subunit 14C 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
GRB10 N/A 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
PTPRA N/A 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
RAPH1 N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
PPP1R1B PPP1R1B, DARPP32: Protein phosphatase 1 regulatory subunit 1B 0.051 0.051
EVL EVL, RNB6: Ena/VASP-like protein 0.051 0.051
C9orf88 N/A 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.051 0.109
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.051 0.075
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.075
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.040
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.044
NFIB N/A 0.049 0.0688
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.083
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.083
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.028
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.083
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.083
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.083
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.083
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.028
EDA N/A 0.049 0.028
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.083
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.083
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.083
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.083
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.083
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.083
AQP1 AQP1, CHIP28: Aquaporin-1 0.049 0.044
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.049 0.030
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.044
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.049 0.030
AQP2 AQP2: Aquaporin-2 0.049 0.044
GTF2A1 GTF2A1, TF2A1: Transcription initiation factor IIA subunit 1 0.049 0.030
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.048 0.04
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.048 0.04
RAB5B RAB5B: Ras-related protein Rab-5B 0.047 0.098
CDC23 CDC23: Cell division cycle protein 23 homolog 0.046 0.044
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.046 0.098
CORO1C CORO1C, CRNN4: Coronin-1C 0.046 0.030
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.046 0.036
DLG1 N/A 0.046 0.025
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.046 0.036
SEC31L1 N/A 0.046 0.030
COPE COPE: Coatomer subunit epsilon 0.046 0.036
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.044
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.046 0.044
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.046 0.030
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.052
TBC1D4 TBC1D4: TBC1D4 protein 0.046 0.046
TH TH, TYH: Tyrosine 3-monooxygenase 0.046 0.046
PPP1R14A PPP1R14A, CPI17, PPP1INL: Protein phosphatase 1 regulatory subunit 14A 0.046 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.046 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.046
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.046
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.046 0.040
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.046 0.098
HMGCR HMGCR: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.046 0.030
MT1X MT1X: Metallothionein-1X 0.046 0.044
MT2A MT2A, CES1, MT2: Metallothionein-2 0.046 0.044
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.0453 0.028
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.083
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.028
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.083
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0453 0.028
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.0453 0.028
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.045 0.980
CGA CGA: Glycoprotein hormones alpha chain precursor 0.045 0.109
TSHB TSHB: Thyrotropin subunit beta precursor 0.045 0.109
FSHB FSHB: Follitropin subunit beta precursor 0.045 0.109
LHB LHB: Lutropin subunit beta precursor 0.045 0.109
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.045 0.109
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.028
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.044
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.049
CNN3 CNN3: Calponin-3 0.044 0.049
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.044
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.044 0.030
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.047
AQP4 AQP4: Aquaporin-4 0.044 0.075
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.047
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.025
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.075
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.075
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.075
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.043 0.030
GNB2L1 Lung cancer oncogene 7 0.0425 0.034
SH3BP3 0.0425 0.034
NUP214 N/A 0.0425 0.034
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.042 0.046
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.041 0.047
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.041 0.098
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.878
MT1F MT1F, PRO0376: Metallothionein-1F 0.041 0.044
INHA INHA: Inhibin alpha chain precursor 0.041 0.980
KRT8 KRT8, CYK8: Keratin, type II cytoskeletal 8 0.041 0.034
FGF5 FGF5: Fibroblast growth factor 5 precursor 0.041 0.109
NDP NDP: Norrin precursor 0.041 0.109
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.041 0.109
LOC645745 MT1H: Metallothionein-1H 0.041 0.044
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.025
GLRB GLRB: Glycine receptor subunit beta precursor 0.041 0.075
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.025
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 0.025
FGF9 FGF9: Glia-activating factor precursor 0.041 0.098
BMP7 BMP7, OP1: Bone morphogenetic protein 7 precursor 0.041 0.878
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.052
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.052
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.025
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.025
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.025
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.044
RAC2 RAC2: Ras-related C3 botulinum toxin substrate 2 precursor 0.039 0.040
RAB5A RAB5A, RAB5: Ras-related protein Rab-5A 0.039 0.040
COPB2 COPB2: Coatomer subunit beta' 0.038 0.030
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.038 0.044
ZFYVE16 ZFYVE16, KIAA0305: Zinc finger FYVE domain-containing protein 16 0.038 0.030
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.038 0.044
DYNC1I2 N/A 0.038 0.044
GMCL1L GMCL1L, GCL: Germ cell-less protein-like 1-like 0.038 14.50
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.038 0.044
EEF2 EEF2, EF2: Elongation factor 2 0.038 0.098
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.038 0.030
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.038 0.030
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.037 0.083
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.083
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.083
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.028
GHR GHR: Growth hormone receptor precursor 0.037 0.083
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.083
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.037 0.083
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.083
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.083
RAP1GA1 N/A 0.037 0.034
PFKFB1 N/A 0.037 0.062
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.028
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.028
CRLF3 N/A 0.036 0.028
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.028
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.028
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.028
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.028
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.036 0.028
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.028
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.028
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.028
RHOG RHOG, ARHG: Rho-related GTP-binding protein RhoG precursor 0.0354 0.044
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.035 0.036
PDK1 PDK1: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precu 0.035 0.030
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.046
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.0338 0.051
TPH1 N/A 0.0338 0.051
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.049
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.033 0.047
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.025
SCARB2 SCARB2, CD36L2, LIMPII: Lysosome membrane protein 2 0.033 0.075
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.025
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.025
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.025
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.033 71.20
RHO RHO, OPN2: Rhodopsin 0.033 0.083
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.083
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.083
PRLR PRLR: Prolactin receptor precursor 0.033 0.083
F3 F3: Tissue factor precursor 0.032 0.083
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.032 0.028
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.083
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.083
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.083
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.028
ITGB4 N/A 0.032 0.083
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.083
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.032 0.025
NCSTN NCSTN, KIAA0253, UNQ1874/PRO4317: Nicastrin precursor 0.032 0.025
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.028
RRAS RRAS: Ras-related protein R-Ras precursor 0.0308 0.098
RHOB RHOB, ARH6, ARHB: Rho-related GTP-binding protein RhoB precursor 0.0308 0.109
PPP1R14D PPP1R14D, GBPI: Protein phosphatase 1 regulatory subunit 14D 0.031 0.046
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.030 0.051
PPP1R1A PPP1R1A, IPP1: Protein phosphatase 1 regulatory subunit 1A 0.030 0.051
GJA5 GJA5: Gap junction alpha-5 protein 0.030 0.051
PEBP1 PEBP1, PBP, PEBP: Phosphatidylethanolamine-binding protein 1 0.030 0.046
C1QBP C1QBP, GC1QBP, HABP1, SF2P32: Complement component 1 Q subcomponent-binding prot 0.030 0.030
ABCB9 ABCB9, KIAA1520: ATP-binding cassette sub-family B member 9 precursor 0.030 0.030
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.025
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.025
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.025
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.052
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.083
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.028
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.083
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.083
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.025
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.025
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.029 0.044
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.029 0.044
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.029 0.044
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.029 0.030
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.029 0.030
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.029 0.044
AIP AIP, XAP2: AH receptor-interacting protein 0.029 0.044
ZBTB40 ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40 0.029 0.030
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.029 0.030
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.029 0.044
WDR54 N/A 0.028 0.034
C20orf18 N/A 0.028 0.034
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.049
SYTL4 Endocrine transmitter regulatory protein 0.028 0.034
UHRF1 0.028 0.034
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.034
NASP NASP: Nuclear autoantigenic sperm protein 0.028 0.049
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.028 0.034
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.028 0.044
ABCB1 ABCB1, MDR1, PGY1: Multidrug resistance protein 1 0.028 0.030
RRAD RRAD, RAD: GTP-binding protein RAD 0.028 0.098
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.047
SLC2A1 SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1 0.027 0.047
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
LILRB1 N/A 0.027 0.028
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.028
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.027 0.028
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.028
CD69 CD69: Early activation antigen CD69 0.027 0.028
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.028
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.052
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.075
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.025
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.025
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.025
ZBTB33 KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso 0.026 0.034
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.026 0.028
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.025 0.049
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.025 0.049
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.049
F5 F5: Coagulation factor V precursor 0.025 0.049
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.098
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.030
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.044
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.030
RASD1 RASD1, AGS1, DEXRAS1: Dexamethasone-induced Ras-related protein 1 precursor 0.025 0.098
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.030
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.030
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.025 0.098
0.228
Total Score 4.01