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Evidence of Interaction Between MAPK1 and TGFBR1

The interaction score between MAPK1 and TGFBR1 is 3.92.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and TGFBR1 = 0.06

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismMAPK1 OrthologueTGFBR1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 P20792 1
fly P40417 1 Q8MKS1 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and TGFBR1:
Domains in MAPK1Domains in TGFBR1
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000719 Protein kinase
IPR011009 Protein kinase-like
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR003605 TGF beta receptor, GS motif
IPR008271 Serine/threonine protein kinase, active site
IPR000333 Activin type II receptor

The Chi square scores for co-occurrence of domains that are present in MAPK1 and TGFBR1 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR000719 Protein kinase 30.6895
IPR011009 Protein kinase-like IPR011009 Protein kinase-like 26.2215
IPR003527 MAP kinase IPR008271 Serine/threonine protein kinase, active site 20.8159
IPR008349 ERK1/2 MAP kinase IPR008271 Serine/threonine protein kinase, active site 17.555
IPR002290 Serine/threonine protein kinase IPR008271 Serine/threonine protein kinase, active site 8.88805
IPR000719 Protein kinase IPR008271 Serine/threonine protein kinase, active site 6.25263
IPR008271 Serine/threonine protein kinase, active site IPR008271 Serine/threonine protein kinase, active site 5.82656
IPR008349 ERK1/2 MAP kinase IPR000719 Protein kinase 4.26499
IPR000719 Protein kinase IPR011009 Protein kinase-like 2.94434
IPR003527 MAP kinase IPR000719 Protein kinase 2.81413
IPR002290 Serine/threonine protein kinase IPR011009 Protein kinase-like 2.72953
IPR008271 Serine/threonine protein kinase, active site IPR003605 TGF beta receptor, GS motif 2.72078
IPR011009 Protein kinase-like IPR008271 Serine/threonine protein kinase, active site 2.11823
IPR008271 Serine/threonine protein kinase, active site IPR000333 Activin type II receptor 2.08498
IPR002290 Serine/threonine protein kinase IPR000719 Protein kinase 0.986464
IPR008271 Serine/threonine protein kinase, active site IPR000472 TGF-beta receptor/activin receptor, type I/II 0.960112
IPR000719 Protein kinase IPR000472 TGF-beta receptor/activin receptor, type I/II 0.743605
IPR011009 Protein kinase-like IPR000333 Activin type II receptor 0.671282
IPR011009 Protein kinase-like IPR000472 TGF-beta receptor/activin receptor, type I/II 0.26297
IPR003527 MAP kinase IPR011009 Protein kinase-like 0.150555
IPR000719 Protein kinase IPR000333 Activin type II receptor 0.128195
IPR008349 ERK1/2 MAP kinase IPR011009 Protein kinase-like 0.0192176
IPR011009 Protein kinase-like IPR003605 TGF beta receptor, GS motif 0.00000665251
IPR000719 Protein kinase IPR003605 TGF beta receptor, GS motif 0.0000045302

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in TGFBR1
  • Green Domain is present in both MAPK1 and TGFBR1

 0.049
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: TGFBR1

PTMResidueReference
Phosphorylation 172 PubMed, HPRD
Phosphorylation 176 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: TGFBR1

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between MAPK1 and TGFBR1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andTGFBR1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and TGFBR1 has 887 interactors of which there are 667 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for TGFBR1-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.029
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.041
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 94.70 0.057
DUSP21 DUSP21, LMWDSP21: Dual specificity protein phosphatase 21 72.50 3.81
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.098
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.062
DUSP14 DUSP14, MKP6: Dual specificity protein phosphatase 14 46.80 4.70
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 7.38 0.028
CDK2 CDK2: Cell division protein kinase 2 6.80 0.033
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.029
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 3.35 0.033
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.073
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.041
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 0.025
PLEK PLEK, P47: Pleckstrin 0.515 0.051
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.090
CRKL CRKL: Crk-like protein 0.461 0.090
JAK1 0.461 0.090
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.073
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.073
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.090
MSN MSN: Moesin 0.461 0.090
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.064
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.090
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.100
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.063
STK10 STK10: Uncharacterized protein STK10 0.385 0.033
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.033
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.071
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.090
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.073
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.372 0.057
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.073
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.073
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.090
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.090
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.073
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.058
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.372 0.064
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.033
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.113
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.073
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.064
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.072
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.081
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.166
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.100
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.100
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.307 0.063
DOK1 DOK1: Docking protein 1 0.275 0.073
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.064
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.071
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.090
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.113
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.148
HCK N/A 0.275 0.064
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.275 0.073
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.064
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.041
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.275 0.073
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.037
GAB2 N/A 0.251 0.065
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.126
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.251 0.051
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.081
BACH1 BACH1: Transcription regulator protein BACH1 0.251 0.025
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.065
WASPIP N/A 0.233 0.051
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.029
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.033
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.233 0.029
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.027
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.033
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.033
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.033
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.233 27.30
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.225 0.073
SH3BP5 N/A 0.225 0.073
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.073
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.071
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.148
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.073
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.090
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.073
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.046
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.0453
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.030
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.210 0.0453
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.037
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.192 388.00
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.081
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.081
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.063
CXorf9 N/A 0.188 0.041
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.188 0.073
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.033
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.027
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.033
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.027
RPS6KB1 N/A 0.188 0.027
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.058
FNBP1 N/A 0.188 0.033
GMIP GMIP: GEM-interacting protein 0.188 0.073
SEC24B SEC24B: Protein transport protein Sec24B 0.188 0.041
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.174 0.034
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.073
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.090
PSD TYL: TYL protein 0.171 0.064
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.073
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.073
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.064
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.073
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.041
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.109
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PSCD2 N/A 0.165 0.109
NSBP1 NSBP1: Nucleosome-binding protein 1 0.165 0.0688
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.109
BID BID: BH3-interacting domain death agonist 0.165 0.034
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.109
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.109
MAP2K5 N/A 0.165 0.109
NF2 NF2, SCH: Merlin 0.165 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.109
HD HD, IT15: Huntingtin 0.155 0.030
H1FX H1FX: Histone H1x 0.155 0.025
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.0263
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.155 0.0453
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.037
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.0263
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.096
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.166
ERF ERF: ETS domain-containing transcription factor ERF 0.152 0.025
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.072
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.081
SNCB SNCB: Beta-synuclein 0.152 0.065
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.072
CREB1 CREB1: cAMP response element-binding protein 0.148 0.062
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.098
CCNT2 CCNT2: Cyclin-T2 0.148 0.030
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.098
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.098
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.098
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.098
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.030
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.098
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.098
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.098
STAT3 0.148 0.098
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.098
ELMO1 N/A 0.148 0.098
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.098
ARHGEF7 N/A 0.148 0.098
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.098
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.030
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.062
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.098
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.098
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.146 0.033
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.146 0.090
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.146 0.090
DUSP13 DUSP13, TMDP: Dual specificity protein phosphatase 13 0.141 3.81
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.139 0.035
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.139 0.033
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.029
CDKN1B CDKN1B, KIP1: Cyclin-dependent kinase inhibitor 1B 0.139 0.035
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.033
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.033
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.051
ATM ATM: Serine-protein kinase ATM 0.139 0.041
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.033
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.033
CD2AP CD2AP: CD2-associated protein 0.139 0.041
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.043
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.041
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.139 0.035
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.064
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.064
RDX RDX: Radixin 0.136 0.058
VIL2 N/A 0.136 0.090
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.058
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.064
STMN1 STMN1, LAP18, OP18: Stathmin 0.136 0.058
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.136 0.041
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.132 0.081
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.129 0.041
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.045
RB1 RB1: Retinoblastoma-associated protein 0.127 0.025
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.127 0.037
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.030
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.037
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.127 0.037
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.030
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.0263
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.032
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.062
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.081
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.072
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.123 0.037
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.100
NRAS NRAS, HRAS1: GTPase NRas precursor 0.118 0.073
CDC37 CDC37: Hsp90 co-chaperone Cdc37 0.116 0.034
PGAM1 PGAM1, PGAMA, CDABP0006: Phosphoglycerate mutase 1 0.114 0.041
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.114 0.027
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.029
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.029
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.114 0.028
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.033
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.041
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.114 0.035
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.026
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.033
RPS10 RPS10: 40S ribosomal protein S10 0.114 0.041
THOC1 THOC1, HPR1: THO complex subunit 1 0.114 0.029
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.027
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.073
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.064
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.090
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.073
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.090
STMN2 STMN2, SCG10, SCGN10: Stathmin-2 0.111 0.058
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.065
PLD2 PLD2: Phospholipase D2 0.111 0.090
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.100
BMX N/A 0.110 0.081
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.109 0.065
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.072
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.072
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.045
HMGA2 HMGA2, HMGIC: High mobility group protein HMGI-C 0.109 0.025
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.051
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.064
ETV1 ETV1, ER81: ETS translocation variant 1 0.098 0.025
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.072
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.081
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.148
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.165
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.148
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.058
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.064
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.041
PLD1 PLD1: Phospholipase D1 0.097 0.073
DAB1 DAB1: Disabled homolog 1 0.097 0.064
TST TST: Thiosulfate sulfurtransferase 0.097 0.073
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.058
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.073
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.058
NBN NBN, NBS, NBS1, P95: Nibrin 0.0971 0.025
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.0453
NFATC1 N/A 0.096 0.039
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.096 0.0453
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.096 0.025
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.032
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.096 0.037
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.037
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.037
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.046
SMAD7 SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7 0.096 0.063
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.081
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.055
CD44 N/A 0.091 0.062
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.054
PTPRZ1 N/A 0.090 0.097
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.073
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.090
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.086 0.041
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.029
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.027
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.0308
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.041
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.086 0.027
CTPS CTPS: CTP synthase 1 0.086 0.033
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.086 27.30
RELA RELA, NFKB3: Transcription factor p65 0.086 0.035
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.033
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.026
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.086 0.026
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 0.086 0.057
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.029
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.086 0.033
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.049
MAPKAPK5 N/A 0.083 0.04
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.049
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.04
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.049
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.04
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.049
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.04
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.034
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.049
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.04
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.049
MAPK15 N/A 0.083 0.049
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.034
CASP9 CASP9, MCH6: Caspase-9 precursor 0.083 0.049
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.083 0.049
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.04
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.04
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.04
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.083 0.049
IRF3 IRF3: Interferon regulatory factor 3 0.080 0.039
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.111
KIAA1012 KIAA1012: Protein TRS85 homolog 0.078 0.033
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.078 0.033
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.0263
PRKAA1 N/A 0.077 0.037
LIMK2 LIMK2: LIM domain kinase 2 0.077 0.037
STK16 N/A 0.077 0.046
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.062
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.057
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.037
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.037
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.037
ATP2B1 N/A 0.075 0.031
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.055
FADD FADD, MORT1: Protein FADD 0.075 0.077
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.036
GIT2 N/A 0.075 0.036
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.044
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.030
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.044
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.044
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.044
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.036
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.036
SNX3 N/A 0.075 0.098
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.044
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.075 0.044
CNN2 CNN2: Calponin-2 0.075 0.049
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.036
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.030
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.030
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.044
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.047
TSC2 TSC2, TSC4: Tuberin 0.075 0.044
RBL1 RBL1: Retinoblastoma-like protein 1 0.075 0.030
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.044
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.036
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.036
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.044
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.036
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.044
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.036
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.036
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.075 0.036
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.036
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.075 29.60
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.036
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.036
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.036
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.04
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.044
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.225
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.073 0.088
GABRR1 N/A 0.0727 0.123
CDC42 CDC42: Cell division control protein 42 homolog precursor 0.073 0.033
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.191
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.071 0.073
WDR1 N/A 0.070 0.025
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.070 0.034
CDK6 CDK6: Cell division protein kinase 6 0.069 0.033
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.033
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.069 0.027
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.064
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.069 0.033
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.027
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.069 0.027
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.069 0.027
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.033
CDK4 CDK4: Cell division protein kinase 4 0.069 0.027
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.069 0.033
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.029
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.086
BCL2L1 BCL2L1, BCL2L, BCLX: Apoptosis regulator Bcl-X 0.0688 0.034
MCL1 MCL1: Induced myeloid leukemia cell differentiation protein Mcl-1 0.0688 0.034
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.049
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.088
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.063 0.072
BCL2 BCL2: Apoptosis regulator Bcl-2 0.063 0.031
COPA COPA: Coatomer subunit alpha 0.063 0.029
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.063 0.028
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.063 0.033
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.063 0.041
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.063 0.064
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.062 0.032
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.062 0.030
COBL N/A 0.062 0.032
SPTAN1 N/A 0.062 0.032
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.034
GRLF1 N/A 0.062 0.100
CHAT CHAT: Choline O-acetyltransferase 0.062 0.030
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.099
GLRA1 N/A 0.058 0.097
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.088
PFKFB2 PFKFB2: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.057 0.046
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.062
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.062
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.062
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.056 0.029
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.033
CASP2 CASP2, ICH1, NEDD2: Caspase-2 precursor 0.056 0.051
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.056 0.033
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.056 0.027
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.026
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.027
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.051
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.027
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.056 0.033
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.029
WEE1 WEE1: Wee1-like protein kinase 0.056 0.033
SALF GTF2A1L, ALF, GTF2A1LF: TFIIA-alpha and beta-like factor 0.056 0.025
NOS1 NOS1: Nitric-oxide synthase, brain 0.056 0.027
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.037
EIF4EBP1 EIF4EBP1: Eukaryotic translation initiation factor 4E-binding protein 1 0.053 0.034
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.053 0.030
RAB4A N/A 0.052 0.0688
LIMS1 N/A 0.052 0.0263
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.052 0.032
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.051 0.051
PPP1R14C PPP1R14C, KEPI: Protein phosphatase 1 regulatory subunit 14C 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
GRB10 N/A 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
PTPRA N/A 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
RAPH1 N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
PPP1R1B PPP1R1B, DARPP32: Protein phosphatase 1 regulatory subunit 1B 0.051 0.051
EVL EVL, RNB6: Ena/VASP-like protein 0.051 0.051
C9orf88 N/A 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.051 0.081
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.051 0.097
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.044
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.040
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.029
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.050 0.033
CDKL5 N/A 0.049 0.037
NFIB N/A 0.049 0.045
KRT1 KRT1, KRTA: Keratin, type II cytoskeletal 1 0.049 0.037
DAPK2 DAPK2: Death-associated protein kinase 2 0.049 0.037
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.083
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.083
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.028
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.083
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.083
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.083
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.083
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.028
EDA N/A 0.049 0.028
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.083
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.083
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.083
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.083
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.083
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.083
AQP1 AQP1, CHIP28: Aquaporin-1 0.049 0.033
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.049 0.028
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.033
AQP2 AQP2: Aquaporin-2 0.049 0.041
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.026
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.048 0.030
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.048 0.030
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.047 0.036
RAB5B RAB5B: Ras-related protein Rab-5B 0.047 0.098
CDC23 CDC23: Cell division cycle protein 23 homolog 0.046 0.033
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.046 0.064
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.046 0.029
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.046 0.033
LPXN LPXN, LDLP: Leupaxin 0.046 0.033
COPE COPE: Coatomer subunit epsilon 0.046 0.033
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.041
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.046 0.041
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.046 0.028
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.048
TBC1D4 TBC1D4: TBC1D4 protein 0.046 0.046
TH TH, TYH: Tyrosine 3-monooxygenase 0.046 0.046
PPP1R14A PPP1R14A, CPI17, PPP1INL: Protein phosphatase 1 regulatory subunit 14A 0.046 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.046 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.046
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.046
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.046 0.030
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.046 0.073
MT1X MT1X: Metallothionein-1X 0.046 0.029
MT2A MT2A, CES1, MT2: Metallothionein-2 0.046 0.029
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.062
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.032
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.077
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0453 0.026
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.0453 0.026
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.045 0.731
CGA CGA: Glycoprotein hormones alpha chain precursor 0.045 0.072
TSHB TSHB: Thyrotropin subunit beta precursor 0.045 0.072
FSHB FSHB: Follitropin subunit beta precursor 0.045 0.072
LHB LHB: Lutropin subunit beta precursor 0.045 0.072
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.045 0.081
MYO3A MYO3A: Myosin IIIA 0.044 0.041
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.033
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.027
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.051
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.044 0.027
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.032
CNN3 CNN3: Calponin-3 0.044 0.032
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.041
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.029
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.033
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.044 0.054
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.047
AQP4 AQP4: Aquaporin-4 0.044 0.075
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.047
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.025
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 71.20
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.075
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.075
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.075
AKR7A2 AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2 0.043 0.033
GNB2L1 Lung cancer oncogene 7 0.0425 0.031
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.042 0.042
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.041 0.035
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.041 0.064
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.808
MT1F MT1F, PRO0376: Metallothionein-1F 0.041 0.033
INHA INHA: Inhibin alpha chain precursor 0.041 0.644
KRT8 KRT8, CYK8: Keratin, type II cytoskeletal 8 0.041 0.025
FGF5 FGF5: Fibroblast growth factor 5 precursor 0.041 0.081
NDP NDP: Norrin precursor 0.041 0.065
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.041 0.072
LOC645745 MT1H: Metallothionein-1H 0.041 0.033
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.044
GLRB GLRB: Glycine receptor subunit beta precursor 0.041 0.044
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.049
FGF9 FGF9: Glia-activating factor precursor 0.041 0.064
BMP7 BMP7, OP1: Bone morphogenetic protein 7 precursor 0.041 0.655
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.052
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.052
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.029
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.029
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.033
RAC2 RAC2: Ras-related C3 botulinum toxin substrate 2 precursor 0.039 0.036
RAB5A RAB5A, RAB5: Ras-related protein Rab-5A 0.039 0.030
CREBBP CREBBP, CBP: CREB-binding protein 0.038 0.035
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.038 0.033
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.038 0.029
DYNC1I2 N/A 0.038 0.026
GMCL1L GMCL1L, GCL: Germ cell-less protein-like 1-like 0.038 0.028
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.038 0.033
EEF2 EEF2, EF2: Elongation factor 2 0.038 0.090
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.038 0.028
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.037 0.077
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.077
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.077
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.026
GHR GHR: Growth hormone receptor precursor 0.037 0.055
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.055
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.037 0.077
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.062
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.096
RAP1GA1 N/A 0.037 0.025
PFKFB1 N/A 0.037 0.046
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.032
CRLF3 N/A 0.036 0.026
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.026
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.026
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.032
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.026
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.026
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.026
RHOG RHOG, ARHG: Rho-related GTP-binding protein RhoG precursor 0.0354 0.0407
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.035 0.041
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.034
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.0338 0.0338
TPH1 N/A 0.0338 0.0338
MAL2 MAL2: Protein MAL2 0.034 0.034
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.049
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.033 0.043
SCARB2 SCARB2, CD36L2, LIMPII: Lysosome membrane protein 2 0.033 0.049
RHO RHO, OPN2: Rhodopsin 0.033 0.077
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.062
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.055
PRLR PRLR: Prolactin receptor precursor 0.033 0.055
F3 F3: Tissue factor precursor 0.032 0.055
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.032 0.026
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.049
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.096
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.077
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.032
ITGB4 N/A 0.032 0.062
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.049
ZYX ZYX: Zyxin 0.032 0.0263
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.026
RRAS RRAS: Ras-related protein R-Ras precursor 0.0308 43.20
RHOB RHOB, ARH6, ARHB: Rho-related GTP-binding protein RhoB precursor 0.0308 0.072
PPP1R14D PPP1R14D, GBPI: Protein phosphatase 1 regulatory subunit 14D 0.031 0.053
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.030 0.047
PPP1R1A PPP1R1A, IPP1: Protein phosphatase 1 regulatory subunit 1A 0.030 0.038
GJA5 GJA5: Gap junction alpha-5 protein 0.030 0.038
PEBP1 PEBP1, PBP, PEBP: Phosphatidylethanolamine-binding protein 1 0.030 0.030
C1QBP C1QBP, GC1QBP, HABP1, SF2P32: Complement component 1 Q subcomponent-binding prot 0.030 0.030
ABCB9 ABCB9, KIAA1520: ATP-binding cassette sub-family B member 9 precursor 0.030 0.030
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.044
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.069
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.039
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.055
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.055
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.055
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.069
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.029 0.033
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.029 0.026
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.029 0.033
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.029 0.046
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.029 0.029
AIP AIP, XAP2: AH receptor-interacting protein 0.029 0.051
ZBTB40 ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40 0.029 0.035
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.029 0.029
WDR54 N/A 0.028 0.034
C20orf18 N/A 0.028 0.034
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.049
SYTL4 Endocrine transmitter regulatory protein 0.028 0.034
UHRF1 0.028 0.034
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.034
NASP NASP: Nuclear autoantigenic sperm protein 0.028 0.049
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.028 0.034
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.028 0.029
ABCB1 ABCB1, MDR1, PGY1: Multidrug resistance protein 1 0.028 0.028
RRAD RRAD, RAD: GTP-binding protein RAD 0.028 0.073
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.0308
SLC2A1 SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1 0.027 0.043
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.032
CD69 CD69: Early activation antigen CD69 0.027 0.032
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.034
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.069
ZBTB33 KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso 0.026 0.025
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.025 0.037
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.025 0.032
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.0453
F5 F5: Coagulation factor V precursor 0.025 0.032
LMO6 LMO6: LIM domain only protein 6 0.025 0.036
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.098
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.030
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.044
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.030
RASD1 RASD1, AGS1, DEXRAS1: Dexamethasone-induced Ras-related protein 1 precursor 0.025 0.098
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.030
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.030
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.025 0.098
0.299
Total Score 3.92