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Evidence of Interaction Between MAPK1 and MDGA1

The interaction score between MAPK1 and MDGA1 is 1.71.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in MAPK1 and MDGA1:
Domains in MAPK1Domains in MDGA1
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR003598 Immunoglobulin C-2 type
IPR007110 Immunoglobulin-like
IPR003961 Fibronectin, type III
IPR000998 MAM

The Chi square scores for co-occurrence of domains that are present in MAPK1 and MDGA1 are listed below.

Domain 1Domain 2Chi Square
IPR008271 Serine/threonine protein kinase, active site IPR007110 Immunoglobulin-like 49.9657
IPR008271 Serine/threonine protein kinase, active site IPR003961 Fibronectin, type III 30.5883
IPR008271 Serine/threonine protein kinase, active site IPR003598 Immunoglobulin C-2 type 17.9033
IPR011009 Protein kinase-like IPR007110 Immunoglobulin-like 16.6203
IPR002290 Serine/threonine protein kinase IPR003961 Fibronectin, type III 13.198
IPR000719 Protein kinase IPR007110 Immunoglobulin-like 11.3335
IPR008349 ERK1/2 MAP kinase IPR003961 Fibronectin, type III 1.72177
IPR011009 Protein kinase-like IPR003598 Immunoglobulin C-2 type 1.32999
IPR000719 Protein kinase IPR003961 Fibronectin, type III 0.712801
IPR011009 Protein kinase-like IPR003961 Fibronectin, type III 0.616354
IPR003527 MAP kinase IPR003961 Fibronectin, type III 0.246402
IPR000719 Protein kinase IPR003598 Immunoglobulin C-2 type 0.142823

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in MDGA1
  • Green Domain is present in both MAPK1 and MDGA1

 0.014
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: MDGA1

PTMResidueReference
N-linked 247 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: MDGA1

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between MAPK1 and MDGA1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andMDGA1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and MDGA1 has 1538 interactors of which there are 434 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for MDGA1-Interactor (?)
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.0688
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.109
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.109
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.0688
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 4.15 0.083
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.109
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.109
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.0688
PLEK PLEK, P47: Pleckstrin 0.515 0.0688
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.509 0.028
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.109
CRKL CRKL: Crk-like protein 0.461 0.109
JAK1 0.461 0.109
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.044
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.044
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.109
MSN MSN: Moesin 0.461 0.109
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.109
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.049
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.109
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.0688
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.109
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.109
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.109
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.109
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.109
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.109
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.109
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.109
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.109
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.109
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.109
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.109
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.109
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.109
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.044
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.044
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.049
DOK1 DOK1: Docking protein 1 0.275 0.109
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.109
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.0688
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.109
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.109
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.109
HCK N/A 0.275 0.109
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.109
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.109
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.109
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.260 0.044
GAB2 N/A 0.251 0.044
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.109
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.044
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.109
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.109
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.049
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.109
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.109
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.109
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.0688
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.109
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.109
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.109
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.044
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.0688
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.109
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.192 0.083
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.109
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.109
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.0688
CXorf9 N/A 0.188 0.109
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.109
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.109
RPS6KB1 N/A 0.188 0.109
FNBP1 N/A 0.188 0.109
GMIP GMIP: GEM-interacting protein 0.188 0.049
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.044
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.109
PSD TYL: TYL protein 0.171 0.109
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.109
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.049
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.049
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.034
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.109
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PSCD2 N/A 0.165 0.109
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.044
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.044
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.044
NF2 NF2, SCH: Merlin 0.165 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.109
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.044
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.109
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.165
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.044
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.109
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.109
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.109
ETS2 ETS2: Protein C-ets-2 0.152 0.034
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.109
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.109
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.109
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.109
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.109
STAT3 0.148 0.044
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.109
ELMO1 N/A 0.148 0.109
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.109
ARHGEF7 N/A 0.148 0.109
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.109
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.109
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.0688
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.109
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.044
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.109
CD2AP CD2AP: CD2-associated protein 0.139 0.044
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.028
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.049
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.049
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.034
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.109
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.049
RDX RDX: Radixin 0.136 0.109
VIL2 N/A 0.136 0.109
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.109
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.109
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.0688
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.109
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.109
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.124 0.028
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.165
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.044
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.109
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.04
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.109
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.049
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.049
THOC1 THOC1, HPR1: THO complex subunit 1 0.114 0.028
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.044
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.049
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.109
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.109
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.049
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.109
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.109
PLD2 PLD2: Phospholipase D2 0.111 0.109
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.109
BMX N/A 0.110 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.109
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.044
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.0688
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.0688
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.044
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.109
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.109
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.165
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.165
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.028
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.165
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.109
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.109
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.0688
PLD1 PLD1: Phospholipase D1 0.097 0.109
DAB1 DAB1: Disabled homolog 1 0.097 0.049
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.109
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.049
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.109
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.04
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.04
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.049
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.109
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.165
CD44 N/A 0.091 0.083
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.028
PTPRZ1 N/A 0.090 0.165
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.109
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.165
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.109
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.028
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.109
TP53 TP53, P53: Cellular tumor antigen p53 0.086 0.034
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.109
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.044
MAPK15 N/A 0.083 0.109
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.049
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.083
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.165
LCP1 LCP1, PLS2: Plastin-2 0.078 0.049
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.109
STK16 N/A 0.077 0.044
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.056
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.044
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.075 0.028
ATP2B1 N/A 0.075 0.028
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.165
FADD FADD, MORT1: Protein FADD 0.075 0.028
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.109
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.0688
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.044
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.044
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.109
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.04
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.109
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.028
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.109
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.109
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.04
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.109
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.044
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.049
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.165
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.073 0.028
GABRR1 N/A 0.0727 0.028
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.165
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.071 0.044
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.109
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.109
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.109
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.028
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.165
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.165
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.063 0.165
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.028
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.049
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.049
SPTAN1 N/A 0.062 0.109
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.056
GRLF1 N/A 0.062 0.049
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.165
GLRA1 N/A 0.058 0.028
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.165
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.083
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.057 0.028
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.083
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.056
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.056 0.165
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.165
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.044
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.109
TP73 TP73, P73: Tumor protein p73 0.055 0.0688
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.052 0.04
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.049
GRB10 N/A 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.051 0.165
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.051 0.028
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.028
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.044
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.049
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.083
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.083
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.028
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.165
EDA N/A 0.049 0.083
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.165
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.028
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.083
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.165
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.165
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.109
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.046 0.034
DLG1 N/A 0.046 0.028
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.049
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.046 0.052
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.046 0.049
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.028
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.051
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.046 0.044
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.046 0.165
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.0453 0.028
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.165
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.028
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.165
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0453 0.028
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.0453 0.028
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.045 0.083
CGA CGA: Glycoprotein hormones alpha chain precursor 0.045 0.083
TSHB TSHB: Thyrotropin subunit beta precursor 0.045 0.083
FSHB FSHB: Follitropin subunit beta precursor 0.045 0.083
LHB LHB: Lutropin subunit beta precursor 0.045 0.083
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.045 0.083
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.165
MYO3A MYO3A: Myosin IIIA 0.044 0.049
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.109
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.109
CNN3 CNN3: Calponin-3 0.044 0.049
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.044
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.109
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.109
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.028
AQP4 AQP4: Aquaporin-4 0.044 0.028
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.028
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.028
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.028
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.028
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.028
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.083
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.049
XRCC1 XRCC1: DNA-repair protein XRCC1 0.0425 0.0688
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.0425 0.028
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.041 0.028
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.041 0.165
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.083
INHA INHA: Inhibin alpha chain precursor 0.041 0.028
FGF5 FGF5: Fibroblast growth factor 5 precursor 0.041 0.165
NDP NDP: Norrin precursor 0.041 0.083
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.041 0.165
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.165
GLRB GLRB: Glycine receptor subunit beta precursor 0.041 0.028
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.165
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 0.028
FGF9 FGF9: Glia-activating factor precursor 0.041 0.165
BMP7 BMP7, OP1: Bone morphogenetic protein 7 precursor 0.041 0.028
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.028
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.028
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.165
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.165
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.165
CST7 CST7: Cystatin-F precursor 0.039 0.028
MYH9 MYH9: Myosin-9 0.038 0.0688
MDN1 MDN1, KIAA0301: Midasin 0.038 0.049
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.044
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.037 0.028
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.165
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.165
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.083
GHR GHR: Growth hormone receptor precursor 0.037 0.165
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.165
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.037 0.083
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.165
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.165
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.036 0.027
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.165
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.165
CRLF3 N/A 0.036 0.056
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.165
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.165
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.165
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.165
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.036 0.083
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.165
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.165
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.165
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.035 0.04
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.051
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.165
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.033 0.028
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.028
SCARB2 SCARB2, CD36L2, LIMPII: Lysosome membrane protein 2 0.033 0.028
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.028
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.028
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.028
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.033 0.028
RHO RHO, OPN2: Rhodopsin 0.033 0.028
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.028
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.165
PRLR PRLR: Prolactin receptor precursor 0.033 0.165
F3 F3: Tissue factor precursor 0.032 0.165
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.032 0.028
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.083
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.165
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.083
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.028
ITGB4 N/A 0.032 0.165
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.083
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.049
IPO7 IPO7: Uncharacterized protein IPO7 0.032 0.044
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.032 0.028
NCSTN NCSTN, KIAA0253, UNQ1874/PRO4317: Nicastrin precursor 0.032 0.028
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.165
AP2M1 AP2M1, CLAPM1, KIAA0109: AP-2 complex subunit mu-1 0.032 0.034
RYR2 RYR2: Ryanodine receptor 2 0.031 0.034
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.165
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.165
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.165
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.028
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.083
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.083
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.083
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.028
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.165
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.028
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.029 0.049
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.029 0.028
THOP1 THOP1: Thimet oligopeptidase 0.029 0.049
DSP DSP: Desmoplakin 0.028 0.052
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.049
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.049
LNX1 N/A 0.028 0.028
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.028 0.083
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.028
SLC2A1 SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1 0.027 0.028
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
LILRB1 N/A 0.027 0.056
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.165
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.027 0.028
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.165
CD69 CD69: Early activation antigen CD69 0.027 0.165
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.165
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.083
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.028
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.056
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.056
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.028
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.109
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.025 0.165
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.025 0.165
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.165
F5 F5: Coagulation factor V precursor 0.025 0.165
SCRIB N/A 0.025 0.028
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.049
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.049
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.04
MYO18A 0.025 0.049
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.049
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.034
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.034
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.049
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.025 0.049
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.028
0.299
Total Score 1.71