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Evidence of Interaction Between MAPK1 and MDM4

The interaction score between MAPK1 and MDM4 is 7.43.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and MDM4 = 0.03

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology N/A N/A
Domains Domains present in MAPK1 and MDM4:
Domains in MAPK1Domains in MDM4
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR001841 Zn-finger, RING
IPR001876 Zn-finger, Ran-binding
IPR003121 SWIB complex, BAF60b
IPR010984 MDM2 oncoprotein

The Chi square scores for co-occurrence of domains that are present in MAPK1 and MDM4 are listed below.

Domain 1Domain 2Chi Square
IPR011009 Protein kinase-like IPR001841 Zn-finger, RING 15.6712
IPR000719 Protein kinase IPR001841 Zn-finger, RING 14.0542
IPR002290 Serine/threonine protein kinase IPR001841 Zn-finger, RING 2.86027
IPR008271 Serine/threonine protein kinase, active site IPR001841 Zn-finger, RING 2.52183

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in MDM4
  • Green Domain is present in both MAPK1 and MDM4

 0.083
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: MDM4

PTMResidueReference
Phosphorylation 161 PubMed, HPRD
Phosphorylation 342 PubMed, HPRD
Phosphorylation 365 PubMed, HPRD
Phosphorylation 367 PubMed, HPRD
Phosphorylation 391 PubMed, HPRD
Phosphorylation 403 PubMed, HPRD
Proteolytic Cleavage 361 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: MDM4

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between MAPK1 and MDM4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andMDM4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and MDM4 has 819 interactors of which there are 705 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for MDM4-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.049
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.028
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.028
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.028
CDK2 CDK2: Cell division protein kinase 2 6.80 0.077
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 3.35 0.037
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 2.02 0.030
PLEK PLEK, P47: Pleckstrin 0.515 0.026
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.0453
JAK1 0.461 0.032
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.034
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.062
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.026
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.416 0.026
ELF1 ELF1: ETS-related transcription factor Elf-1 0.416 0.048
STK10 STK10: Uncharacterized protein STK10 0.385 0.062
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.077
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.037
JUND JUND: Transcription factor jun-D 0.372 0.039
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.037
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.037
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.037
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.372 0.026
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.062
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.030
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.0453
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.344 0.062
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.307 0.026
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.077
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.077
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.037
HCK N/A 0.275 0.037
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.055
ETS1 ETS1, EWSR2: Protein C-ets-1 0.275 0.039
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.037
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.275 0.026
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.032
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.0453
JUNB JUNB: Transcription factor jun-B 0.275 0.039
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.026
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.046
BACH1 BACH1: Transcription regulator protein BACH1 0.251 0.062
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.062
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.077
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.062
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.062
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.233 0.026
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.062
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.037
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.077
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.225 0.060
CCNH CCNH: Cyclin-H 0.225 0.034
JUN JUN: Transcription factor AP-1 0.225 0.039
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.077
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.077
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.210 0.039
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.077
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.077
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.210 0.081
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.208 0.114
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.032
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.062
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.062
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.055
RPS6KB1 N/A 0.188 0.062
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.062
FNBP1 N/A 0.188 0.026
CXorf9 N/A 0.188 0.026
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.188 0.039
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.048
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.077
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.174 0.083
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.037
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.171 0.060
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.165 0.052
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.04
MAP2K5 N/A 0.165 0.049
NF2 NF2, SCH: Merlin 0.165 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.165 0.028
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.049
BID BID: BH3-interacting domain death agonist 0.165 0.028
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.062
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.155 0.081
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.123
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.062
HD HD, IT15: Huntingtin 0.155 0.0453
H1FX H1FX: Histone H1x 0.155 0.039
ERF ERF: ETS domain-containing transcription factor ERF 0.152 0.039
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.032
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.032
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.037
ETS2 ETS2: Protein C-ets-2 0.152 0.039
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.052
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.049
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.083
ELMO1 N/A 0.148 0.052
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.028
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.028
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.049
CREB1 CREB1: cAMP response element-binding protein 0.148 0.028
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.028
CCNT2 CCNT2: Cyclin-T2 0.148 0.028
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.028
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.083
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.083
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.146 0.0263
ATM ATM: Serine-protein kinase ATM 0.139 0.062
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.062
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.032
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.139 0.039
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.062
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.139 0.039
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.062
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.139 0.077
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.062
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.123
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.055
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.062
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.077
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.062
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.137 0.083
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.083
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.029
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.136 0.034
CCNB1 Cyclin B1 0.136 0.039
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.129 0.077
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.062
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.127 0.062
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.062
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.077
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.062
RB1 RB1: Retinoblastoma-associated protein 0.127 0.039
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.127 0.055
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.124 0.051
ERG ERG: Transcriptional regulator ERG 0.123 0.039
PPP1R8 N/A 0.118 0.039
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.118 0.039
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.118 0.034
CDK5 CDK5: Cell division protein kinase 5 0.114 0.062
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.062
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.062
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.062
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.114 0.062
RPS10 RPS10: 40S ribosomal protein S10 0.114 0.072
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.114 0.062
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.114 0.039
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.062
THOC1 THOC1, HPR1: THO complex subunit 1 0.114 0.081
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.055
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.114 0.062
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.111 0.063
ELK1 ELK1: ETS domain-containing protein Elk-1 0.111 0.039
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.055
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.0453
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.029
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.037
BMX N/A 0.110 0.037
HMGA2 HMGA2, HMGIC: High mobility group protein HMGI-C 0.109 0.055
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.055
ETV1 ETV1, ER81: ETS translocation variant 1 0.098 0.039
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.032
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.032
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.062
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.062
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.0971 0.026
NBN NBN, NBS, NBS1, P95: Nibrin 0.0971 0.048
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.062
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.055
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.096 0.049
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.096 0.077
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.062
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.062
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.096 0.126
NFATC1 N/A 0.096 0.026
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.088 0.031
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.037
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.087 0.062
MATR3 MATR3, KIAA0723: Matrin-3 0.087 0.062
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.087 0.026
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.087 0.039
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.029
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.100
CDK5R1 CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor 0.086 0.034
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.055
MTA1 MTA1: Metastasis-associated protein MTA1 0.086 0.026
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 0.086 0.032
TP53 TP53, P53: Cellular tumor antigen p53 0.086 0.077
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.086 0.062
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.086 0.062
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.055
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.086 0.077
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.055
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.037
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.055
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.083 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.083
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.028
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.109
MAPK15 N/A 0.083 0.083
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.028
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.049
CASP9 CASP9, MCH6: Caspase-9 precursor 0.083 0.109
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.083 0.109
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.083
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.083
HES6 HES6: Transcription cofactor HES-6 0.083 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.083
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.049
MAPKAPK5 N/A 0.083 0.083
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.083
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.04
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.083
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.083
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.049
IRF3 IRF3: Interferon regulatory factor 3 0.080 0.039
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.032
SFRS5 SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5 0.078 0.077
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.078 0.077
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.078 0.026
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.078 0.062
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.077
DDX51 DDX51: ATP-dependent RNA helicase DDX51 0.078 0.026
UBE2E3 UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3 0.078 0.072
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.078 0.062
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.0263
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.062
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.077
MYB MYB: Myb proto-oncogene protein 0.077 0.026
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.062
PRKAA1 N/A 0.077 0.062
LIMK2 LIMK2: LIM domain kinase 2 0.077 0.032
STK16 N/A 0.077 0.062
FADD FADD, MORT1: Protein FADD 0.075 0.045
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.083
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.083
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.083
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.075 0.028
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.083
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.049
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.075 0.028
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.083
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.052
TFAP4 TFAP4: Transcription factor AP-4 0.075 0.028
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.083
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.083
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.083
TSC2 TSC2, TSC4: Tuberin 0.075 0.04
RBL1 RBL1: Retinoblastoma-like protein 1 0.075 0.052
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.04
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.083
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.083
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.075 0.028
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.083
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.083
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.083
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.083
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.083
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.083
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.075 0.083
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.075 0.028
MAX MAX: Protein max 0.075 0.028
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.083
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.083
GIT2 N/A 0.075 0.083
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.075 0.083
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.083
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.075 0.028
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.071 0.039
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.071 0.026
SLC4A1AP SLC4A1AP: Uncharacterized protein SLC4A1AP 0.071 0.048
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.071 0.039
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.071 0.026
KIAA0853 N/A 0.070 0.026
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.070 0.077
RGS14 N/A 0.070 0.032
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.070 0.152
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.070 0.062
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.070 0.077
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.070 0.077
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.070 0.026
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.049
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.069 0.077
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.069 0.062
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.062
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.069 0.077
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.069 0.062
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.055
CDK4 CDK4: Cell division protein kinase 4 0.069 0.062
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.062
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.0453
NR5A1 NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1 0.069 0.026
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.069 0.077
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.069 0.055
CDK6 CDK6: Cell division protein kinase 6 0.069 0.062
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.062
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.069 0.055
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.025
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.063 0.062
CSTF2T CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant 0.063 0.062
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.063 0.081
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.063 0.077
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.030
CUL5 CUL5, VACM1: Cullin-5 0.063 0.152
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.063 0.026
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.063 0.077
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.063 0.026
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.063 0.062
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.063 0.062
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.063 0.077
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.063 0.077
EP300 N/A 0.063 0.026
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.063 0.077
YY1 YY1: Transcriptional repressor protein YY1 0.063 0.062
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.063 0.077
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.063 0.062
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.063 0.026
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.063 0.077
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.063 0.026
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.063 0.026
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.063 0.077
TIAL1 TIAL1: Nucleolysin TIAR 0.063 0.062
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.063 0.100
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.063 0.026
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.063 0.037
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.063 0.062
COPA COPA: Coatomer subunit alpha 0.063 0.026
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.063 0.026
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.063 0.026
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.063 0.0453
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.063 0.062
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.063 0.037
CKAP1 TBCB, CG22, CKAP1: Tubulin folding cofactor B 0.063 0.032
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.062
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.062 0.065
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.062 0.062
GTF2F2 N/A 0.060 0.034
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.060 0.039
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.045
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.055
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.056 0.062
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.032
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.049
WEE1 WEE1: Wee1-like protein kinase 0.056 0.062
CASP2 CASP2, ICH1, NEDD2: Caspase-2 precursor 0.056 0.100
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.062
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.056 0.062
TERT TERT, EST2, TCS1, TRT: Telomerase reverse transcriptase 0.056 0.026
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.0263
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.062
PPARA PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha 0.055 0.026
TP73 TP73, P73: Tumor protein p73 0.055 0.077
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.054 0.034
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.054 0.039
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.054 0.026
RAB4A N/A 0.052 0.028
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.052 0.052
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.052 0.052
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.052 0.062
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.052 0.026
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.052 0.062
RBM14 RBM14, SIP: RNA-binding protein 14 0.052 0.096
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.052 0.026
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.052 0.062
DDX21 DDX21: Nucleolar RNA helicase 2 0.052 0.026
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.052 0.062
FUBP1 N/A 0.052 0.0453
MECP2 MECP2: Methyl-CpG-binding protein 2 0.052 0.062
CHUK N/A 0.052 0.026
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.052 0.077
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.052 0.096
NCOA3 N/A 0.052 0.026
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.052 0.077
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.050 0.055
DAPK2 DAPK2: Death-associated protein kinase 2 0.049 0.055
CDKL5 N/A 0.049 0.062
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.034
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.0688
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.034
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.034
MYF5 MYF5: Myogenic factor 5 0.049 0.026
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.077
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.049 0.048
DYRK3 N/A 0.049 0.055
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.049 0.039
MKI67 MKI67: Antigen KI-67 0.048 0.039
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.048 0.0453
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.048 0.123
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.048 0.034
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.048 0.030
SOX8 SOX8: Transcription factor SOX-8 0.047 0.028
LMNA LMNA, LMN1: Lamin-A/C 0.047 0.028
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.047 0.052
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.047 0.052
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.046 0.077
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.046 0.037
XPO1 XPO1, CRM1: Exportin-1 0.046 0.0453
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.046 0.026
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.046 0.026
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.046 0.077
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.046 0.152
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.046 0.026
ZNF76 ZNF76, D6S229E: Zinc finger protein 76 0.046 0.077
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.046 0.096
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.046 0.055
CBX3 CBX3: Chromobox protein homolog 3 0.046 0.062
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.046 0.039
EIF3S6 EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6 0.046 0.030
SPEN SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein 0.046 0.077
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.046 0.077
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.046 0.026
SRF SRF: Serum response factor 0.046 0.026
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.046 0.037
SP3 SP3: Transcription factor Sp3 0.046 0.062
HDAC3 HDAC3: Histone deacetylase 3 0.046 0.026
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.046 0.062
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.046 0.037
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.046 0.026
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.046 0.037
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.046 0.030
TBCE TBCE: Tubulin-specific chaperone E 0.046 0.037
SSB SSB: Lupus La protein 0.046 0.062
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.046 0.062
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.046 0.062
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.046 0.062
CORO1C CORO1C, CRNN4: Coronin-1C 0.046 0.026
BRPF1 BRPF1, BR140: Peregrin 0.046 0.077
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.046 0.030
MTF1 MTF1: Metal regulatory transcription factor 1 0.046 0.077
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0453 0.051
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.055
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.049
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.044 0.049
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.044 0.077
MYO3A MYO3A: Myosin IIIA 0.044 0.077
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.049
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.029
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.055
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.044 0.077
ESR1 ESR1, ESR, NR3A1: Estrogen receptor 0.044 0.039
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.034
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.034
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.043 0.026
SOX4 SOX4: Transcription factor SOX-4 0.043 0.032
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.043 0.034
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.043 0.039
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.043 0.039
ZNF267 ZNF267: Zinc finger protein 267 0.0425 0.062
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.0425 0.037
DNMT1 DNMT1, AIM, DNMT: DNA 0.0425 0.026
TCOF1 N/A 0.0425 0.152
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.0425 0.062
SH3BP3 0.0425 0.062
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.031
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.025
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.062
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.040 0.077
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.038 0.037
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.038 0.039
RNF11 RNF11, CGI-123: RING finger protein 11 0.038 0.049
WBSCR20A N/A 0.038 0.026
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.038 0.077
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.038 0.062
ZNF330 ZNF330, NOA36: Zinc finger protein 330 0.038 0.026
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.038 0.034
NOL1 N/A 0.038 0.026
GMCL1L GMCL1L, GCL: Germ cell-less protein-like 1-like 0.038 0.077
EEF2 EEF2, EF2: Elongation factor 2 0.038 0.032
SATB1 SATB1: DNA-binding protein SATB1 0.038 0.080
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.038 0.030
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.038 0.0453
VCP VCP: Transitional endoplasmic reticulum ATPase 0.038 0.037
YEATS2 KIAA1197, YEATS2: YEATS domain-containing protein 2 0.038 0.026
HTATSF1 HTATSF1: HIV Tat-specific factor 1 0.038 0.062
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.038 0.037
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.038 0.077
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.038 0.072
PHF10 N/A 0.038 0.077
RANBP9 RANBP9, RANBPM: Ran-binding protein 9 0.038 0.109
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.038 0.077
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.038 0.032
ZNF335 ZNF335: Zinc finger protein 335 0.038 0.077
SNRP70 SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa 0.038 0.062
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.038 0.026
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.035 0.100
LEF1 LEF1: Lymphoid enhancer-binding factor 1 0.035 0.026
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.035 0.039
REST REST, NRSF, XBR: RE1-silencing transcription factor 0.032 0.123
TGIF2 TGIF2: Homeobox protein TGIF2 0.032 0.060
ZFX ZFX: Zinc finger X-chromosomal protein 0.032 0.077
IPO7 IPO7: Uncharacterized protein IPO7 0.032 0.037
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.032 0.123
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.032 0.026
HIVEP1 N/A 0.032 0.077
SFRS15 SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15 0.032 0.096
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.032 0.026
RBM6 RBM6, DEF3: RNA-binding protein 6 0.032 0.062
CUL2 CUL2: Cullin-2 0.032 0.051
KRT18 KRT18: Uncharacterized protein KRT18 0.031 0.031
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.045
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.039
SYMPK SYMPK, SPK: Symplekin 0.029 0.077
LIG1 LIG1: DNA ligase 1 0.029 0.026
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.029 0.037
RUNX1 N/A 0.029 0.026
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.029 0.037
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.029 0.062
H2AFX H2AFX, H2AX: Histone H2A.x 0.029 0.026
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.029 0.123
ZBTB40 ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40 0.029 0.077
MEF2D MEF2D: Myocyte-specific enhancer factor 2D 0.029 0.032
CASP3 CASP3, CPP32: Caspase-3 precursor 0.029 0.032
KIAA0690 N/A 0.029 0.062
DUSP22 DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22 0.029 0.026
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 0.029 0.026
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.029 0.039
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.029 0.026
RBM7 0.029 0.055
GSTP1 GSTP1, FAEES3, GST3: Glutathione S-transferase P 0.029 0.0263
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.029 0.026
MSH6 MSH6, GTBP: DNA mismatch repair protein MSH6 0.029 0.062
RBMX2 RBMX2, CGI-79: RNA-binding motif protein, X-linked 2 0.029 0.062
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.029 0.026
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.029 0.096
SP1 SP1, TSFP1: Transcription factor Sp1 0.029 0.062
RREB1 RREB1, FINB: RAS-responsive element-binding protein 1 0.029 0.026
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.029 0.026
TCF8 ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1 0.029 0.062
ZNF224 ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224 0.029 0.062
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.029 0.062
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.029 0.037
RCP9 CRCP: DNA-directed RNA polymerase III subunit RPC9 0.029 0.026
POLA2 POLA2: DNA polymerase subunit alpha B 0.029 0.026
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.029 0.029
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.029 0.029
DUSP15 N/A 0.028 0.028
UHRF1 0.028 0.083
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.028 0.083
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.083
PHLDB2 N/A 0.028 0.028
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.028
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.028 0.083
PPEF1 N/A 0.028 0.028
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
AR AR, DHTR, NR3C4: Androgen receptor 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.083
CORO6 N/A 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.083
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.028 0.028
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
KIF1B N/A 0.028 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.04
CASP14 CASP14: Caspase-14 precursor 0.028 0.049
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.083
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.028 0.083
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.083
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.028 0.083
MITF MITF: Microphthalmia-associated transcription factor 0.028 0.028
CASP6 CASP6, MCH2: Caspase-6 precursor 0.028 0.049
PKP4 PKP4: Plakophilin-4 0.028 0.04
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.028 0.109
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.028 0.083
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
WDR54 N/A 0.028 0.028
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
IRF7 N/A 0.028 0.028
C13orf8 N/A 0.028 0.028
C20orf18 N/A 0.028 0.165
DSP DSP: Desmoplakin 0.028 0.028
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.028 0.04
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
CUTL1 CUTL1: Homeobox protein cut-like 1 0.028 0.052
HDAC8 N/A 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.028
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.028 0.028
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.028 0.052
ZNF579 ZNF579: Zinc finger protein 579 0.028 0.083
CABLES1 N/A 0.028 0.028
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.028 0.083
SNRPB N/A 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.052
ZNF265 N/A 0.028 0.028
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.028 0.049
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.028 0.083
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.028 0.025
RFX1 RFX1: MHC class II regulatory factor RFX1 0.028 0.034
FOXL2 FOXL2: Forkhead box protein L2 0.028 0.039
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.025
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.055
PHF8 PHF8, KIAA1111, ZNF422: PHD finger protein 8 0.026 0.032
POU2F1 POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1 0.026 0.062
KIF23 N/A 0.026 0.026
USP21 USP21, USP23: Ubiquitin carboxyl-terminal hydrolase 21 0.026 0.100
ESPL1 N/A 0.026 0.026
TRRAP N/A 0.026 0.026
AFAP AFAP1, AFAP: Actin filament-associated protein 1 0.026 0.026
PPARGC1A PPARGC1A, LEM6, PGC1, PGC1A, PPARGC1: Peroxisome proliferator-activated receptor 0.026 0.062
ZBTB33 KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso 0.026 0.055
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.028
BCOR N/A 0.025 0.028
MAP2K3 N/A 0.025 0.028
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.052
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.165
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.028
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.025 0.109
SPAST SPAST, KIAA1083, SPG4: Spastin 0.025 0.049
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.025 0.083
BRD4 N/A 0.025 0.028
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.083
DCTN1 DCTN1: Dynactin subunit 1 0.025 0.049
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.052
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.025 0.028
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.028
SON 0.025 0.028
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.083
PRKCB1 N/A 0.025 0.028
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.028
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.028
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.025 0.028
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.083
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.025 0.083
GRK6 N/A 0.025 0.028
NUP98 N/A 0.025 0.028
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.028
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.028
RNF20 0.025 0.083
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.025 0.083
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.083
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.028
FLJ23436 N/A 0.025 0.028
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.025 0.083
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.028
NIPBL N/A 0.025 0.083
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.028
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.025 0.028
ATXN2L N/A 0.025 0.028
DLX3 DLX3: Homeobox protein DLX-3 0.025 0.052
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.028
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.028
NES N/A 0.025 0.028
KCTD1 0.025 0.028
HDAC7A N/A 0.025 0.028
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.083
DIDO1 N/A 0.025 0.083
CAMKK1 N/A 0.025 0.028
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.025 0.083
CAMK2A N/A 0.025 0.028
RSN CLIP1, CYLN1, RSN: CAP-Gly domain-containing linker protein 1 0.025 0.049
USP16 USP16: Ubiquitin carboxyl-terminal hydrolase 16 0.025 0.109
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.083
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.165
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.025 0.028
ZNF598 ZNF598: Zinc finger protein 598 0.025 0.028
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.028
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.025 0.028
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.025 0.083
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.025 0.083
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.025 0.083
ADK ADK: Adenosine kinase 0.025 0.028
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.165
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.025 0.049
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.025 0.028
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.028
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.025 0.083
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.083
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.025 0.083
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.028
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.083
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.025 0.052
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.049
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.028
TCEA1 N/A 0.025 0.028
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.025 0.083
NHN1 NHN1: Conserved nuclear protein NHN1 0.025 0.028
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.028
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.028
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.083
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.025 0.083
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.028
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.028
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.083
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.028
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.083
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.028
MAPK8IP3 N/A 0.025 0.028
SEC13L1 N/A 0.025 0.028
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.028
C20orf77 N/A 0.025 0.028
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.083
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.028
G3BP2 G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2 0.025 0.049
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.025 0.083
HTATIP N/A 0.025 0.028
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.083
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.028
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.025 0.083
0.299
Total Score 7.43