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Evidence of Interaction Between MAPK1 and CASR

The interaction score between MAPK1 and CASR is 3.86.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and CASR = -0.10

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology N/A N/A
Domains Domains present in MAPK1 and CASR:
Domains in MAPK1Domains in CASR
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000337 G-protein coupled receptor family 3, metabotropic glutamate receptor-like
IPR001828 Extracellular ligand-binding receptor
IPR000068 Extracellular calcium-sensing receptor
IPR011500 NCD3G_GPCR.

The Chi square scores for co-occurrence of domains that are present in MAPK1 and CASR are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR001828 Extracellular ligand-binding receptor 2.6265
IPR011009 Protein kinase-like IPR001828 Extracellular ligand-binding receptor 1.29785

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in CASR
  • Green Domain is present in both MAPK1 and CASR

 0.049
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: CASR

PTMResidueReference
Glycosylation 90 PubMed, HPRD
Glycosylation 130 PubMed, HPRD
Glycosylation 261 PubMed, HPRD
Glycosylation 287 PubMed, HPRD
Glycosylation 446 PubMed, HPRD
Glycosylation 468 PubMed, HPRD
Glycosylation 488 PubMed, HPRD
Phosphorylation 888 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: CASR

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between MAPK1 and CASR that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andCASR. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and CASR has 659 interactors of which there are 389 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for CASR-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.032
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.04
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.04
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 10.50 0.109
CDK2 CDK2: Cell division protein kinase 2 6.80 0.037
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 2.53 0.109
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.072
GNAI2 Galphai2 protein 1.71 0.098
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 1.42 0.037
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 1.03 0.109
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 0.165
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.509 0.123
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.0263
CRKL CRKL: Crk-like protein 0.461 0.100
JAK1 0.461 0.032
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.032
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.029
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.072
MSN MSN: Moesin 0.461 0.032
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.029
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.032
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.456 0.152
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.449 0.152
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.032
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 0.405 0.109
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.033
STK10 STK10: Uncharacterized protein STK10 0.385 0.032
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.065
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.0263
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.032
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.072
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.029
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.072
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.032
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.029
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.072
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.037
DOK1 DOK1: Docking protein 1 0.275 0.037
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.032
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.100
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.100
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.081
GAB2 N/A 0.251 0.032
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.029
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.233 0.041
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.065
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.072
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.029
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.072
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.029
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.081
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.0263
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.081
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.0453
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.072
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.025
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.072
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.033
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.037
CXorf9 N/A 0.188 0.081
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.029
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.032
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.032
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.029
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.029
RPS6KB1 N/A 0.188 0.065
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.072
GMIP GMIP: GEM-interacting protein 0.188 0.072
PSD TYL: TYL protein 0.171 0.029
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.032
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.037
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.100
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.081
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.045
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.04
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.049
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PSCD2 N/A 0.165 0.049
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.109
NF2 NF2, SCH: Merlin 0.165 0.049
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.049
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.049
HD HD, IT15: Huntingtin 0.155 0.0263
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.033
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.037
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.032
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.100
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.0453
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.109
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.109
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.109
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.049
STAT3 0.148 0.04
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.049
ELMO1 N/A 0.148 0.049
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.109
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.109
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.109
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.109
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.146 0.032
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.146 0.032
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.139 0.025
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.072
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.032
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.029
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.037
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.0263
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.065
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.062
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.065
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.065
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.072
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.081
RDX RDX: Radixin 0.136 0.032
VIL2 N/A 0.136 0.032
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.072
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.072
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.136 0.051
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.132 0.032
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.029
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.032
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.037
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.032
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.0453
NRAS NRAS, HRAS1: GTPase NRas precursor 0.118 0.029
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.072
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.072
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.072
CDK5 CDK5: Cell division protein kinase 5 0.114 0.029
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.081
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.037
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.114 0.072
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.029
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.111 0.046
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.032
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.0453
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.032
PLD2 PLD2: Phospholipase D2 0.111 0.057
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.075
BMX N/A 0.110 0.0453
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.052
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.052
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.037
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.037
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.063
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.0453
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.052
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.052
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.052
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.028
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.052
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.100
PLD1 PLD1: Phospholipase D1 0.097 0.057
DAB1 DAB1: Disabled homolog 1 0.097 0.037
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.037
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.0453
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.065
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.096 0.032
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.030
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.046
GNA14 GNA14: Guanine nucleotide-binding protein alpha-14 subunit 0.095 0.085
PTPRZ1 N/A 0.090 0.034
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.0453
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.126
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.072
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.032
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.055
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.081
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.086 0.037
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.037
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.081
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.049
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.049
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.049
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.049
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.049
MAPK15 N/A 0.083 0.049
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.109
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.152
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.078 0.072
LCP1 LCP1, PLS2: Plastin-2 0.078 0.072
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.029
PRKAA1 N/A 0.077 0.032
LIMK2 LIMK2: LIM domain kinase 2 0.077 0.081
STK16 N/A 0.077 0.0453
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.109
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.037
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.032
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.032
FADD FADD, MORT1: Protein FADD 0.075 0.026
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.075 0.034
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.034
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.109
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.049
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.109
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.049
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.049
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.109
CNN2 CNN2: Calponin-2 0.075 0.109
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.049
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.034
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.083
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.049
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.049
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.049
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.109
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.049
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.109
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.109
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.049
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.109
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.109
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.109
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.109
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.039
GABRR1 N/A 0.0727 0.032
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.060
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.071 0.025
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.071 0.0263
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.070 0.100
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.065
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.069 0.065
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.069 0.057
CDK6 CDK6: Cell division protein kinase 6 0.069 0.0453
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.037
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.069 0.0453
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.081
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.069 0.032
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.032
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.069 0.037
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.069 0.0453
CDK4 CDK4: Cell division protein kinase 4 0.069 0.0453
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.029
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.191
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.034
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.063 0.032
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.063 0.072
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.063 0.032
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.029
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.029
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.062 0.0453
SPTAN1 N/A 0.062 0.032
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.062
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.039
GLRA1 N/A 0.058 0.026
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.039
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.026
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.081
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.032
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.056 0.032
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.032
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.032
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.037
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.0453
NOS1 NOS1: Nitric-oxide synthase, brain 0.056 0.126
PRKCB1 PRKCB1, PKCB, PRKCB: Protein kinase C beta type 0.055 0.034
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.126
MVP MVP, LRP: Major vault protein 0.052 0.032
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.072
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.072
CDKL5 N/A 0.049 0.0453
KRT1 KRT1, KRTA: Keratin, type II cytoskeletal 1 0.049 0.032
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.028
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.028
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.028
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.028
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.028
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.028
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.083
EDA N/A 0.049 0.028
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.028
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.028
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.028
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.028
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.028
DYRK3 N/A 0.049 0.032
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.0453
NEFL NEFL, NF68, NFL: Neurofilament light polypeptide 0.048 0.029
RAB5B RAB5B: Ras-related protein Rab-5B 0.047 0.049
LMNA LMNA, LMN1: Lamin-A/C 0.047 0.034
XPO1 XPO1, CRM1: Exportin-1 0.046 0.0263
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.046 0.030
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.046 0.072
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.051
EPB41 EPB41, E41P: Protein 4.1 0.046 0.051
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.0425
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0453 0.026
MYO3A MYO3A: Myosin IIIA 0.044 0.037
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.057
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.166
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.044 0.037
CNN3 CNN3: Calponin-3 0.044 0.081
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.027
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.166
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.100
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.044 0.091
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.028
AQP4 AQP4: Aquaporin-4 0.044 0.028
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.028
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.165
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.028
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.028
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.028
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.028
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.032
KRT8 KRT8, CYK8: Keratin, type II cytoskeletal 8 0.041 0.025
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 0.098
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.028
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.028
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.126
NEF3 NEFM, NEF3, NFM: Neurofilament medium polypeptide 0.039 0.032
GFAP GFAP: Glial fibrillary acidic protein 0.039 0.037
MYH9 MYH9: Myosin-9 0.038 0.025
CHP CHP: Calcium-binding protein p22 0.038 0.037
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.057
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.026
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.037 0.0425
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.026
KRT20 KRT20: Keratin, type I cytoskeletal 20 0.034 0.025
NEFH NEFH, KIAA0845, NFH: Neurofilament heavy polypeptide 0.034 0.032
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.109
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.109
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.152
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.109
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.033 0.032
RHO RHO, OPN2: Rhodopsin 0.033 0.0425
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.032
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.026
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.032
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.026
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.032
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.032 0.081
KRT18 KRT18: Uncharacterized protein KRT18 0.031 0.031
DES DES: Desmin 0.031 0.037
RRAS RRAS: Ras-related protein R-Ras precursor 0.0308 0.0453
RHOB RHOB, ARH6, ARHB: Rho-related GTP-binding protein RhoB precursor 0.0308 0.037
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.191
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.026
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.032
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.026
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.026
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.098
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.029 0.065
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.029 0.037
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.029 0.0263
SYMPK SYMPK, SPK: Symplekin 0.029 0.0263
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.029 0.0263
KIAA0690 N/A 0.029 0.030
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.029 0.029
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.029 0.029
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.028 0.109
DSP DSP: Desmoplakin 0.028 0.049
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.028 0.04
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.0688
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.049
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.049
PPEF1 N/A 0.028 0.049
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.04
PKP4 PKP4: Plakophilin-4 0.028 0.04
RRAD RRAD, RAD: GTP-binding protein RAD 0.028 0.030
PRPH PRPH, NEF4, PRPH1: Peripherin 0.0277 0.037
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.0425
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.077
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.062
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.152
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.029
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.026 0.0453
PLA2G4A PLA2G4A, CPLA2, PLA2G4: Cytosolic phospholipase A2 0.0253 0.0338
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.025 0.04
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.025 0.049
MYO18A 0.025 0.109
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.109
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.034
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.109
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.025 0.109
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.049
NIPBL N/A 0.025 0.04
0.299
Total Score 3.86