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Evidence of Interaction Between MAPK1 and FYN

The interaction score between MAPK1 and FYN is 16.40.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and FYN = 0.72

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology N/A N/A
Domains Domains present in MAPK1 and FYN:
Domains in MAPK1Domains in FYN
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR001452 SH3
IPR000980 SH2 motif

The Chi square scores for co-occurrence of domains that are present in MAPK1 and FYN are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR000980 SH2 motif 82.1364
IPR011009 Protein kinase-like IPR000980 SH2 motif 59.6059
IPR008271 Serine/threonine protein kinase, active site IPR008266 Tyrosine protein kinase, active site 41.8291
IPR008271 Serine/threonine protein kinase, active site IPR000980 SH2 motif 41.4368
IPR000719 Protein kinase IPR000719 Protein kinase 30.6895
IPR000719 Protein kinase IPR001452 SH3 27.1334
IPR008271 Serine/threonine protein kinase, active site IPR001452 SH3 27.0049
IPR011009 Protein kinase-like IPR011009 Protein kinase-like 26.2215
IPR002290 Serine/threonine protein kinase IPR008266 Tyrosine protein kinase, active site 25.0766
IPR011009 Protein kinase-like IPR001452 SH3 20.4416
IPR002290 Serine/threonine protein kinase IPR000980 SH2 motif 18.5445
IPR002290 Serine/threonine protein kinase IPR001452 SH3 11.0285
IPR008271 Serine/threonine protein kinase, active site IPR001245 Tyrosine protein kinase 8.08585
IPR000719 Protein kinase IPR008266 Tyrosine protein kinase, active site 6.98997
IPR008271 Serine/threonine protein kinase, active site IPR000719 Protein kinase 6.25263
IPR002290 Serine/threonine protein kinase IPR001245 Tyrosine protein kinase 5.09618
IPR008349 ERK1/2 MAP kinase IPR000719 Protein kinase 4.26499
IPR003527 MAP kinase IPR000980 SH2 motif 3.65309
IPR000719 Protein kinase IPR011009 Protein kinase-like 2.94434
IPR003527 MAP kinase IPR000719 Protein kinase 2.81413
IPR002290 Serine/threonine protein kinase IPR011009 Protein kinase-like 2.72953
IPR000719 Protein kinase IPR001245 Tyrosine protein kinase 2.31134
IPR008271 Serine/threonine protein kinase, active site IPR011009 Protein kinase-like 2.11823
IPR003527 MAP kinase IPR001245 Tyrosine protein kinase 1.50703
IPR008349 ERK1/2 MAP kinase IPR001452 SH3 1.37932
IPR003527 MAP kinase IPR001452 SH3 0.988997
IPR002290 Serine/threonine protein kinase IPR000719 Protein kinase 0.986464
IPR008349 ERK1/2 MAP kinase IPR000980 SH2 motif 0.969135
IPR011009 Protein kinase-like IPR001245 Tyrosine protein kinase 0.178275
IPR003527 MAP kinase IPR011009 Protein kinase-like 0.150555
IPR008349 ERK1/2 MAP kinase IPR011009 Protein kinase-like 0.0192176
IPR011009 Protein kinase-like IPR008266 Tyrosine protein kinase, active site 0.00724826
IPR008349 ERK1/2 MAP kinase IPR001245 Tyrosine protein kinase 0.0000302204

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in FYN
  • Green Domain is present in both MAPK1 and FYN

 0.027
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: FYN

PTMResidueReference
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: FYN

No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between MAPK1 and FYN that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andFYN. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and FYN has 747 interactors of which there are 379 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for FYN-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.0308
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.039
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 94.70 0.039
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.027
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.027
DUSP2 DUSP2, PAC1: Dual specificity protein phosphatase 2 31.70 0.231
DUSP10 DUSP10, MKP5: Dual specificity protein phosphatase 10 12.60 0.027
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.041
MRCL3 MRLC2, MLCB, RLC: Myosin regulatory light chain 2, nonsarcomeric 0.622 0.067
PLEK PLEK, P47: Pleckstrin 0.515 0.053
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.137
CRKL CRKL: Crk-like protein 0.461 0.402
JAK1 0.461 2.91
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.137
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.083
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 1.36
MSN MSN: Moesin 0.461 0.137
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.824
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.083
DUSP7 DUSP7, PYST2: Dual specificity protein phosphatase 7 0.440 0.041
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.666
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 2.39
CDC14A CDC14A: Dual specificity protein phosphatase CDC14A 0.402 0.032
STYXL1 STYXL1, DUSP24, MKSTYX: Serine/threonine/tyrosine-interacting-like protein 1 0.402 0.041
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.137
STK10 STK10: Uncharacterized protein STK10 0.385 0.293
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.137
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 1.11
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.824
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.083
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.083
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.491
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 1.36
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.824
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.0308
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.491
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.050
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 2.91
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.666
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.050
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.041
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.050
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.824
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.666
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.050
DOK1 DOK1: Docking protein 1 0.275 0.050
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.305
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.404
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.050
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.050
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 1.36
HCK N/A 0.275 0.402
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.402
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.041
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.137
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.260 0.137
GAB2 N/A 0.251 0.0308
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.824
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.0308
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.0308
RNGTT RNGTT, CAP1A: mRNA-capping enzyme 0.237 0.027
DUSP9 DUSP9, MKP4: Dual specificity protein phosphatase 9 0.237 0.027
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.233 0.053
WASPIP N/A 0.233 0.137
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.083
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.083
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.050
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.293
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.050
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.067
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.137
SH3BP5 N/A 0.225 0.067
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.402
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.677
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.083
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.041
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.824
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.083
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.053
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.083
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.050
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.210 0.042
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.083
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.192 0.037
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.0308
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.244
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.251
CXorf9 N/A 0.188 0.137
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.188 0.067
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.067
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.067
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.067
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.188 0.053
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.067
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.041
RPS6KB1 N/A 0.188 0.067
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.050
FNBP1 N/A 0.188 0.137
GMIP GMIP: GEM-interacting protein 0.188 0.083
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.244
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.491
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.050
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.0308
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.032
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.265
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.027
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.027
PSCD2 N/A 0.165 0.027
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.265
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.265
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.027
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.265
MAP2K5 N/A 0.165 0.027
NF2 NF2, SCH: Merlin 0.165 0.027
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.027
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.265
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.050
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.155 0.0255
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.067
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.041
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.108
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.491
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.197
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.197
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.027
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.027
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.027
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.027
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.027
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.265
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.265
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.265
STAT3 0.148 0.265
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.027
ELMO1 N/A 0.148 0.027
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.027
ARHGEF7 N/A 0.148 0.027
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.027
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.027
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.217
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.265
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.139 0.039
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.0308
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.041
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.041
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.0308
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.0308
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.083
ATM ATM: Serine-protein kinase ATM 0.139 0.137
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.067
CD2AP CD2AP: CD2-associated protein 0.139 0.0308
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.041
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.067
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.041
VIL2 N/A 0.136 0.0308
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.050
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.050
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.0308
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.108
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.174
MRLC2 Myosin regulatory light chain 0.114 0.027
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.050
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.041
CDK5 CDK5: Cell division protein kinase 5 0.114 0.0308
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.0308
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.041
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.114 0.0308
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.0308
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.041
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.197
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.197
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.174
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.157
BMX N/A 0.110 0.157
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.129
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.176
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.157
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.174
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.143
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.096 0.041
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.0308
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.0308
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.039
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.174
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.087 0.032
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.086 0.041
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.0308
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.041
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.050
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.0308
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.027
MAPKAPK5 N/A 0.083 0.027
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.027
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.027
MAPK15 N/A 0.083 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.027
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.083 2.91
HMGN4 HMGN4, HMG17L3, NHC: High mobility group nucleosome-binding domain-containing pr 0.083 0.108
ARHGEF3 ARHGEF3: Rho guanine nucleotide exchange factor 3 0.083 0.881
CTRL PSMB10, MECL1: Proteasome subunit beta type-10 precursor 0.083 0.042
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.032
LCP1 LCP1, PLS2: Plastin-2 0.078 0.083
PRKAA1 N/A 0.077 0.0308
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.041
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.027
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.027
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.027
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.027
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.027
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.027
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.027
SNX3 N/A 0.075 0.027
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.027
CNN2 CNN2: Calponin-2 0.075 0.027
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.027
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.027
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.027
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.265
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.027
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.027
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.027
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.027
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.027
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.027
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.027
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.075 0.027
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.027
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.027
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.027
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.027
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.027
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.027
PLCB2 0.074 0.083
RIN3 N/A 0.074 1.36
CCND3 CCND3: G1/S-specific cyclin-D3 0.074 0.027
CAPNS1 CAPNS1, CAPN4, CAPNS: Calpain small subunit 1 0.070 0.067
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.0308
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.050
SCAP2 SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R: Src kinase-associated phosphoprotein 2 0.067 0.050
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.330
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.063 0.137
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.050
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.063 0.039
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.063 0.083
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.050
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.050
MTMR6 MTMR6: Myotubularin-related protein 6 0.060 0.050
USP8 USP8, KIAA0055, UBPY: Ubiquitin carboxyl-terminal hydrolase 8 0.060 0.067
NUP50 NUP50, NPAP60L, PRO1146: Nucleoporin 50 kDa 0.060 0.050
SOS2 SOS2: Son of sevenless homolog 2 0.060 0.053
CERK CERK, KIAA1646: Ceramide kinase 0.060 0.083
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.032
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.030
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.157
GRB10 N/A 0.051 0.0288
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.0288
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.0288
CRK CRK: Proto-oncogene C-crk 0.051 0.0288
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.051 0.032
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.027
APBA3 APBA3, MINT3, X11L2: Amyloid beta A4 precursor protein-binding family A member 3 0.050 0.065
ARHGEF18 ARHGEF18: ARHGEF18 protein 0.050 0.067
PLEKHO1 PLEKHO1, CKIP1, OC120, HQ0024c: Pleckstrin homology domain-containing family O m 0.050 0.050
RANBP3 N/A 0.050 0.050
NCF2 NCF2: Neutrophil cytosol factor 2 0.050 0.041
ASB8 ASB8, PP14212: Ankyrin repeat and SOCS box protein 8 0.050 0.050
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.217
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.046 0.039
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.046 0.067
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.039
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.0288
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.0288
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.032
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.039
PIP3-E N/A 0.044 0.067
MTMR1 MTMR1: Myotubularin-related protein 1 0.044 0.067
ARHGAP26 ARHGAP26, GRAF, KIAA0621, OPHN1L: Rho GTPase-activating protein 26 0.044 0.067
CENTB1 CENTB1, KIAA0050: Centaurin-beta 1 0.044 0.083
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.0308
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.162
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.143
LDLRAP1 LDLRAP1, ARH: Low density lipoprotein receptor adapter protein 1 0.041 0.083
SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 0.041 0.824
PLEKHA1 PLEKHA1, TAPP1: Pleckstrin homology domain-containing family A member 1 0.041 0.067
CENTA2 CENTA2: Centaurin-alpha 2 0.041 0.041
MYLIP MYLIP, BZF1, BM-023, PP5242: E3 ubiquitin-protein ligase MYLIP 0.041 0.050
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.108
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.027
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.057
CHP CHP: Calcium-binding protein p22 0.038 0.0308
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.0308
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.032
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.032
KIAA0372 TTC37, KIAA0372: Tetratricopeptide repeat protein 37 0.036 0.041
RASA4 RASA4, CAPRI, GAPL, KIAA0538: Ras GTPase-activating protein 4 0.036 0.050
GABPA GABPA, E4TF1A: GA-binding protein alpha chain 0.036 0.032
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.036 0.050
MTMR3 MTMR3, KIAA0371, ZFYVE10: Myotubularin-related protein 3 0.036 0.0308
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.036 0.050
PTPN9 0.036 0.041
RASA2 RASA2, GAP1M, RASGAP: Ras GTPase-activating protein 2 0.036 0.067
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.108
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.039
CRLF3 N/A 0.036 0.053
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.053
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.065
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.231
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.108
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.108
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.065
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.065
PTPN7 PTPN7: Tyrosine-protein phosphatase non-receptor type 7 0.0308 0.041
RGS3 RGS3: Regulator of G-protein signaling 3 0.030 0.037
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.129
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.162
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.029 0.041
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.029 0.032
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.027
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.027
PPEF1 N/A 0.028 0.027
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.028 0.0308
VAV3 VAV3: Protein vav-3 0.028 0.305
MTM1 MTM1, CG2: Myotubularin 0.028 0.0308
APBB1IP APBB1IP, PREL1, RARP1, RIAM: Amyloid beta A4 precursor protein-binding family B 0.028 0.041
ACP1 ACP1: Protein-tyrosine-phosphatase, isoform 3 0.027 0.027
OSBPL6 OSBPL6, ORP6: Oxysterol-binding protein-related protein 6 0.027 0.027
PLEKHA4 PLEKHA4, PEPP1: Pleckstrin homology domain-containing family A member 4 0.027 0.027
VEPH1 VEPH1, KIAA1692, VEPH: Ventricular zone-expressed PH domain-containing protein h 0.027 0.027
APBB1 APBB1, FE65, RIR: Amyloid beta A4 precursor protein-binding family B member 1 0.027 0.027
ASB10 ASB10: Ankyrin repeat and SOCS box protein 10 0.027 0.027
CADPS CADPS, CAPS, CAPS1, KIAA1121: Calcium-dependent secretion activator 1 0.027 0.027
DOK6 DOK6: Uncharacterized protein DOK6 0.027 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.265
FAM43A N/A 0.027 0.027
ARHGEF1 ARHGEF1: Rho guanine nucleotide exchange factor 1 0.027 0.027
CDC25B CDC25B, CDC25HU2: M-phase inducer phosphatase 2 0.027 0.027
SRA1 APBB3, FE65L2: Amyloid beta A4 precursor protein-binding family B member 3 0.027 0.027
CENTB5 KIAA1716, CENTB5: Centaurin-beta 5 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.265
ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 0.027 0.027
OSBPL9 N/A 0.027 0.027
ASB17 ASB17: Ankyrin repeat and SOCS box protein 17 0.027 0.027
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
PLEKHA3 PLEKHA3, FAPP1: Pleckstrin homology domain-containing family A member 3 0.027 0.027
ASB14 ASB14: Ankyrin repeat and SOCS box protein 14 0.027 0.027
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
ASB3 ASB3: ASB3 protein 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
ASB12 ASB12: Ankyrin repeat and SOCS box protein 12 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.265
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
ASB7 ASB7: Ankyrin repeat and SOCS box protein 7 0.027 0.027
CADPS2 CADPS2, CAPS2, KIAA1591: Calcium-dependent secretion activator 2 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
RASGRF1 RASGRF1, CDC25: Guanine nucleotide-releasing protein 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.265
PSD3 N/A 0.027 0.027
RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 0.027 0.027
PTPN13 N/A 0.027 0.027
LILRB1 N/A 0.027 0.032
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.065
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.143
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.129
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.402
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.026 0.0308
OSTF1 N/A 0.0255 0.137
SIPA1 SIPA1, SPA1: Signal-induced proliferation-associated protein 1 0.0255 0.090
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.025 0.027
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.025 0.027
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.027
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.027
0.299
Total Score 16.40