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Evidence of Interaction Between MAPK1 and DCC

The interaction score between MAPK1 and DCC is 1.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and DCC = -0.07

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology
OrganismMAPK1 OrthologueDCC OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 Q94155 1
fly P40417 1 Q9V6D5 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and DCC:
Domains in MAPK1Domains in DCC
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR003961 Fibronectin, type III
IPR003962 Fibronectin, type III subdomain
IPR008957 Fibronectin, type III-like fold
IPR010560 Neogenin, C-terminal
IPR013098 I-set.

The Chi square scores for co-occurrence of domains that are present in MAPK1 and DCC are listed below.

Domain 1Domain 2Chi Square
IPR008271 Serine/threonine protein kinase, active site IPR007110 Immunoglobulin-like 49.9657
IPR008271 Serine/threonine protein kinase, active site IPR003961 Fibronectin, type III 30.5883
IPR008271 Serine/threonine protein kinase, active site IPR003599 Immunoglobulin subtype 27.8873
IPR008271 Serine/threonine protein kinase, active site IPR003598 Immunoglobulin C-2 type 17.9033
IPR008271 Serine/threonine protein kinase, active site IPR008957 Fibronectin, type III-like fold 16.9163
IPR011009 Protein kinase-like IPR007110 Immunoglobulin-like 16.6203
IPR002290 Serine/threonine protein kinase IPR003961 Fibronectin, type III 13.198
IPR000719 Protein kinase IPR007110 Immunoglobulin-like 11.3335
IPR011009 Protein kinase-like IPR003599 Immunoglobulin subtype 8.86948
IPR002290 Serine/threonine protein kinase IPR008957 Fibronectin, type III-like fold 7.79341
IPR000719 Protein kinase IPR003599 Immunoglobulin subtype 3.60485
IPR000719 Protein kinase IPR003962 Fibronectin, type III subdomain 3.15002
IPR000719 Protein kinase IPR008957 Fibronectin, type III-like fold 2.73832
IPR011009 Protein kinase-like IPR008957 Fibronectin, type III-like fold 2.3557
IPR000719 Protein kinase IPR013098 I-set. 2.01835
IPR011009 Protein kinase-like IPR013098 I-set. 1.96932
IPR011009 Protein kinase-like IPR003962 Fibronectin, type III subdomain 1.9231
IPR008349 ERK1/2 MAP kinase IPR003961 Fibronectin, type III 1.72177
IPR011009 Protein kinase-like IPR003598 Immunoglobulin C-2 type 1.32999
IPR000719 Protein kinase IPR003961 Fibronectin, type III 0.712801
IPR011009 Protein kinase-like IPR003961 Fibronectin, type III 0.616354
IPR008349 ERK1/2 MAP kinase IPR008957 Fibronectin, type III-like fold 0.378958
IPR003527 MAP kinase IPR003961 Fibronectin, type III 0.246402
IPR000719 Protein kinase IPR003598 Immunoglobulin C-2 type 0.142823
IPR003527 MAP kinase IPR008957 Fibronectin, type III-like fold 0.0477166

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in DCC
  • Green Domain is present in both MAPK1 and DCC

 0.014
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: DCC

PTMResidueReference
Proteolytic Cleavage 1290 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: DCC

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between MAPK1 and DCC that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andDCC. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and DCC has 1077 interactors of which there are 410 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for DCC-Interactor (?)
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.041
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.098
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.062
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 4.15 0.029
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.064
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.073
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.045
PLEK PLEK, P47: Pleckstrin 0.515 0.045
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.029
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.064
CRKL CRKL: Crk-like protein 0.461 0.064
JAK1 0.461 0.064
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.026
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.064
MSN MSN: Moesin 0.461 0.064
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.064
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.081
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.041
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.064
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.064
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.064
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.064
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.073
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.064
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.064
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.064
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.064
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.073
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.058
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.064
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.072
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.081
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.033
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.029
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.032
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.064
DOK1 DOK1: Docking protein 1 0.275 0.073
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.073
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.041
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.064
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.113
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.064
HCK N/A 0.275 0.064
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.064
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.072
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.260 0.029
GAB2 N/A 0.251 0.026
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.065
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.033
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.072
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.064
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.029
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.064
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.064
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.064
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.041
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.064
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.064
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.064
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.030
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.046
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.072
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.192 0.064
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.126
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.081
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.063
GMIP GMIP: GEM-interacting protein 0.188 0.029
CXorf9 N/A 0.188 0.073
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.073
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.064
RPS6KB1 N/A 0.188 0.073
FNBP1 N/A 0.188 0.064
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.036
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.058
PSD TYL: TYL protein 0.171 0.073
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.073
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.051
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.041
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.109
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.109
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PSCD2 N/A 0.165 0.109
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.044
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.044
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.044
NF2 NF2, SCH: Merlin 0.165 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
HD HD, IT15: Huntingtin 0.155 0.037
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.029
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.072
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.109
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.033
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.126
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.072
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.100
ETS2 ETS2: Protein C-ets-2 0.152 0.045
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.062
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.098
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.098
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.098
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.098
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.098
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.098
STAT3 0.148 0.040
ELMO1 N/A 0.148 0.098
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.098
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.098
ARHGEF7 N/A 0.148 0.098
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.098
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.029
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.036
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.064
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.029
CD2AP CD2AP: CD2-associated protein 0.139 0.026
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.029
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.030
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.073
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.033
RDX RDX: Radixin 0.136 0.064
VIL2 N/A 0.136 0.064
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.064
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.064
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.045
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.072
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.127 0.037
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.072
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.098
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.032
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.166
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.126
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.064
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.073
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.033
PLD2 PLD2: Phospholipase D2 0.111 0.148
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.029
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.090
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.090
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.064
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.148
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.113
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.126
BMX N/A 0.110 0.081
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.100
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.051
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.045
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.051
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.030
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.100
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.072
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.148
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.165
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.025
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.073
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.073
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.090
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.057
PLD1 PLD1: Phospholipase D1 0.097 0.113
DAB1 DAB1: Disabled homolog 1 0.097 0.033
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.073
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.029
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.081
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.057
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.0453
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.0453
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.100
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.109
CD44 N/A 0.091 0.055
PTPRZ1 N/A 0.090 0.097
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.090
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.073
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.064
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.064
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.109
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.044
MAPK15 N/A 0.083 0.109
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.049
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.136
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.171
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.029
LCP1 LCP1, PLS2: Plastin-2 0.078 0.029
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.081
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.072
STK16 N/A 0.077 0.0407
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.0416
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.109
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.098
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.040
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.044
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.098
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.062
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.040
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.040
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.098
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.044
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.098
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.025
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.098
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.098
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.044
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.111
GABRR1 N/A 0.0727 0.0425
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.307
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.071 0.030
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.058
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.073
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.073
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.097
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.111
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.063 0.100
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.063 0.029
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.063 0.026
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.026
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.029
GRLF1 N/A 0.062 0.057
SPTAN1 N/A 0.062 0.072
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.051
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.111
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.136
GLRA1 N/A 0.058 0.029
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.109
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.057 0.026
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.109
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.0416
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.056 0.064
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.073
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.030
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.090
TP73 TP73, P73: Tumor protein p73 0.055 0.051
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.032
FUBP1 N/A 0.052 0.029
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.052 0.037
GRB10 N/A 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.051 0.081
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.040
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.033
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.056
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.083
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.165
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.028
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.165
EDA N/A 0.049 0.165
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.165
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.028
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.083
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.165
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.073
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.046 0.041
XPO1 XPO1, CRM1: Exportin-1 0.046 0.029
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.033
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.046 0.026
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.046 0.029
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.046 0.033
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.046 0.026
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.046 1.33
MT1X MT1X: Metallothionein-1X 0.046 0.029
MT2A MT2A, CES1, MT2: Metallothionein-2 0.046 0.029
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.123
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.026
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.109
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0453 0.026
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.045 0.072
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.045 0.072
CGA CGA: Glycoprotein hormones alpha chain precursor 0.045 0.072
TSHB TSHB: Thyrotropin subunit beta precursor 0.045 0.072
FSHB FSHB: Follitropin subunit beta precursor 0.045 0.072
LHB LHB: Lutropin subunit beta precursor 0.045 0.072
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.098
MYO3A MYO3A: Myosin IIIA 0.044 0.073
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.090
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.081
CNN3 CNN3: Calponin-3 0.044 0.029
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.046
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.113
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.058
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.025
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.148
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.025
AQP4 AQP4: Aquaporin-4 0.044 0.025
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.025
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.075
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.025
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.025
NUP214 N/A 0.0425 0.025
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.032
XRCC1 XRCC1: DNA-repair protein XRCC1 0.0425 0.051
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.041 0.577
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.029
LOC645745 MT1H: Metallothionein-1H 0.041 0.029
MT1F MT1F, PRO0376: Metallothionein-1F 0.041 0.029
NDP NDP: Norrin precursor 0.041 0.081
FGF5 FGF5: Fibroblast growth factor 5 precursor 0.041 0.100
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.041 0.072
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.136
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.111
FGF9 FGF9: Glia-activating factor precursor 0.041 0.073
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.028
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.028
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.097
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.097
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.097
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.036
MYH9 MYH9: Myosin-9 0.038 0.041
MDN1 MDN1, KIAA0301: Midasin 0.038 0.033
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.191
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.109
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.109
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.191
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.152
GHR GHR: Growth hormone receptor precursor 0.037 0.109
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.251
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.037 0.077
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.109
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.109
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.109
CRLF3 N/A 0.036 0.037
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.109
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.109
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.109
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.109
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.036 0.098
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.109
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.109
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.035 0.033
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.034
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.109
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.056
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.056
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.056
PRLR PRLR: Prolactin receptor precursor 0.033 0.152
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.152
ITGB4 N/A 0.032 0.109
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.152
F3 F3: Tissue factor precursor 0.032 0.109
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.032 0.026
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.152
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.307
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.152
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.026
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.032
IPO7 IPO7: Uncharacterized protein IPO7 0.032 0.0407
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.109
RYR2 RYR2: Ryanodine receptor 2 0.031 0.025
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.097
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.136
NEO1 NEO1, NGN: Neogenin precursor 0.029 11.60
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.026
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.152
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.191
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.123
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.026
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.136
KIAA0690 N/A 0.029 0.051
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.029 0.029
THOP1 THOP1: Thimet oligopeptidase 0.029 0.073
SYMPK SYMPK, SPK: Symplekin 0.029 0.041
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.029 0.029
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.029 0.027
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.029 0.027
PKP4 PKP4: Plakophilin-4 0.028 0.049
DSP DSP: Desmoplakin 0.028 0.049
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.049
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.049
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.049
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.028 0.033
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.123
LILRB1 N/A 0.027 0.037
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.109
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.109
CD69 CD69: Early activation antigen CD69 0.027 0.109
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.062
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.038
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.037
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.037
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.056
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.072
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.025 0.100
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.025 0.100
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.081
F5 F5: Coagulation factor V precursor 0.025 0.081
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.030
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.044
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.098
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.030
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.044
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.044
MYO18A 0.025 0.098
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.030
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.062
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.044
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.025 0.098
0.299
Total Score 1.00