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Evidence of Interaction Between MAPK1 and GNAI1

The interaction score between MAPK1 and GNAI1 is 2.19.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and GNAI1 = 0.07

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismMAPK1 OrthologueGNAI1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBL016W 1 YER020W 1
  • AffinityCaptureWestern

Get References From PubMed
bakers yeast YBL016W 1 YHR005C 1
  • AffinityChromatography
  • Immunoprecipitation
  • InVitro
  • pullDown
  • AffinityCaptureWestern
  • CoLocalization

Get References From PubMed
bakers yeast YGR040W 0.096 YER020W 1
  • AffinityCaptureWestern

Get References From PubMed
bakers yeast YGR040W 0.096 YHR005C 1
fly P40417 1 P20353 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in MAPK1 and GNAI1:
Domains in MAPK1Domains in GNAI1
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408 G-protein alpha subunit, group I

The Chi square scores for co-occurrence of domains that are present in MAPK1 and GNAI1 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit 21.2146
IPR000719 Protein kinase IPR001408 G-protein alpha subunit, group I 15.1364
IPR008271 Serine/threonine protein kinase, active site IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit 14.3705
IPR011009 Protein kinase-like IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit 10.3672
IPR002290 Serine/threonine protein kinase IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit 9.32298
IPR011009 Protein kinase-like IPR001408 G-protein alpha subunit, group I 7.90245

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in GNAI1
  • Green Domain is present in both MAPK1 and GNAI1

 0.014
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: GNAI1

PTMResidueReference
ADP-ribosylarginine 177 PubMed, HPRD
ADP-ribosylcysteine 350 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: GNAI1

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between MAPK1 and GNAI1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andGNAI1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and GNAI1 has 1028 interactors of which there are 174 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for GNAI1-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 1.03
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 10.50 19.90
GNAI2 Galphai2 protein 1.71 0.877
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 1.03 2.47
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 1.33
PLEK PLEK, P47: Pleckstrin 0.515 0.046
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.509 2.47
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.029
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.456 51.30
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.449 0.877
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 0.405 0.995
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.029
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.026
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.029
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.465
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.033
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.0453
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.026
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.064
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 3.65
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.056
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.04
SNCB SNCB: Beta-synuclein 0.152 0.027
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.049
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.044
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.036
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.036
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.032
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.026
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.067
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 15.50
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.040
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.032
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.129 0.029
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.119 0.119
HSPCB 0.119 0.119
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.061
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.041
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.033
BMX N/A 0.110 0.032
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.028
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.063
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.025
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.025
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.025
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.075
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.025
DAB1 DAB1: Disabled homolog 1 0.097 0.033
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.137
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.029
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.029
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.033
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.100
GNA14 GNA14: Guanine nucleotide-binding protein alpha-14 subunit 0.095 38.90
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.694
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 13.90
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.033
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.067
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.046
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.577
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.029
KIAA1012 KIAA1012: Protein TRS85 homolog 0.078 0.026
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.078 0.030
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.078 0.687
ATP2B1 N/A 0.075 0.052
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.036
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.025
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.036
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.073 0.038
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.071 0.714
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.030
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.070 0.057
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 7.92
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.063 0.064
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.067
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.041
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.062 0.0446
COBL N/A 0.062 0.036
SPTAN1 N/A 0.062 0.074
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.026
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.027
NOS1 NOS1: Nitric-oxide synthase, brain 0.056 0.027
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.581
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.052 0.581
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.052 0.032
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.052 0.026
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.028
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.028
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.083
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.028
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.028
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.083
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.028
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.028
NEFL NEFL, NF68, NFL: Neurofilament light polypeptide 0.048 0.0446
CDC23 CDC23: Cell division cycle protein 23 homolog 0.046 0.058
DLG1 N/A 0.046 0.046
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.046 0.654
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.029
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.046 0.035
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.046 0.029
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.058
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.046 0.271
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 1.02
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.0438
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.027
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.026
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.025
AQP4 AQP4: Aquaporin-4 0.044 0.025
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.025
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.025
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.075
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.025
NDP NDP: Norrin precursor 0.041 0.027
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 11.10
GLRB GLRB: Glycine receptor subunit beta precursor 0.041 0.078
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 60.40
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 1.05
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.028
NEF3 NEFM, NEF3, NFM: Neurofilament medium polypeptide 0.039 0.036
GFAP GFAP: Glial fibrillary acidic protein 0.039 0.036
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.038 0.036
APC N/A 0.038 0.032
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.038 0.090
RAP1GA1 N/A 0.037 0.128
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.139
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.114
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.251
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.049
RHO RHO, OPN2: Rhodopsin 0.033 0.859
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.975
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.026
F3 F3: Tissue factor precursor 0.032 0.032
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.032
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.109
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.070
CP110 N/A 0.032 0.027
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.0263
YWHAH YWHAH, YWHA1: 14-3-3 protein eta 0.032 0.036
RYR2 RYR2: Ryanodine receptor 2 0.031 0.0513
OPRM1 OPRM1, MOR1: Mu-type opioid receptor 0.030 0.540
RGS3 RGS3: Regulator of G-protein signaling 3 0.030 0.129
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 13.90
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.049
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.062
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.069
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.029 0.058
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.029 0.036
DPYSL2 DPYSL2, CRMP2: Dihydropyrimidinase-related protein 2 0.029 0.032
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.029 0.073
AIP AIP, XAP2: AH receptor-interacting protein 0.029 0.065
AHCYL1 AHCYL1, DCAL, XPVKONA: Putative adenosylhomocysteinase 2 0.029 0.040
RGS18 RGS18, RGS13: Regulator of G-protein signaling 18 0.028 0.543
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.04
AXIN1 0.028 0.980
NASP NASP: Nuclear autoantigenic sperm protein 0.028 0.044
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.028 0.115
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.694
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.027 0.775
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.026
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.056
RGS4 RGS4: Regulator of G-protein signaling 4 0.026 1.81
DCAMKL1 DCLK1, DCAMKL1, DCDC3A, KIAA0369: Serine/threonine-protein kinase DCLK1 0.026 0.0446
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.044
MYO18A 0.025 0.036
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.044
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.025 0.04
HSPA8 HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein 0.025 3.39
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.036
2.15E-3
Total Score 2.19