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Evidence of Interaction Between MAPK1 and DUSP2

The interaction score between MAPK1 and DUSP2 is 27.40.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and DUSP2 = 0.53

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 6.27E-3
Orthology
OrganismMAPK1 OrthologueDUSP2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBL016W 1 YBR276C 0.101
bakers yeast YGR040W 0.096 YBR276C 0.101
bakers yeast YBL016W 1 YIL113W 0.101
bakers yeast YGR040W 0.096 YIL113W 0.101
bakers yeast YBL016W 1 YNL053W 0.101
  • Immunoprecipitation
  • CoLocalization

Get References From PubMed
bakers yeast YGR040W 0.096 YNL053W 0.101

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.119
Domains Domains present in MAPK1 and DUSP2:
Domains in MAPK1Domains in DUSP2
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase
IPR001763 Rhodanese-like
IPR000340 Dual specificity protein phosphatase
IPR008343 MAP kinase phosphatase

The Chi square scores for co-occurrence of domains that are present in MAPK1 and DUSP2 are listed below.

Domain 1Domain 2Chi Square
IPR003527 MAP kinase IPR008343 MAP kinase phosphatase 991.673
IPR003527 MAP kinase IPR000340 Dual specificity protein phosphatase 575.549
IPR008349 ERK1/2 MAP kinase IPR008343 MAP kinase phosphatase 440.473
IPR008349 ERK1/2 MAP kinase IPR000340 Dual specificity protein phosphatase 317.529
IPR003527 MAP kinase IPR001763 Rhodanese-like 312.614
IPR002290 Serine/threonine protein kinase IPR008343 MAP kinase phosphatase 147.067
IPR008349 ERK1/2 MAP kinase IPR001763 Rhodanese-like 137.552
IPR003527 MAP kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 128.642
IPR008271 Serine/threonine protein kinase, active site IPR008343 MAP kinase phosphatase 108.893
IPR002290 Serine/threonine protein kinase IPR000340 Dual specificity protein phosphatase 108.157
IPR008349 ERK1/2 MAP kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 89.8437
IPR002290 Serine/threonine protein kinase IPR001763 Rhodanese-like 87.68
IPR008271 Serine/threonine protein kinase, active site IPR000340 Dual specificity protein phosphatase 76.5901
IPR008271 Serine/threonine protein kinase, active site IPR001763 Rhodanese-like 75.5504
IPR000719 Protein kinase IPR008343 MAP kinase phosphatase 51.9861
IPR000719 Protein kinase IPR001763 Rhodanese-like 35.31
IPR000719 Protein kinase IPR000340 Dual specificity protein phosphatase 30.0934
IPR011009 Protein kinase-like IPR008343 MAP kinase phosphatase 21.8577
IPR011009 Protein kinase-like IPR000340 Dual specificity protein phosphatase 15.3476
IPR011009 Protein kinase-like IPR001763 Rhodanese-like 14.9678
IPR000719 Protein kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 14.0817
IPR002290 Serine/threonine protein kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 10.8808
IPR011009 Protein kinase-like IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 6.38835
IPR008271 Serine/threonine protein kinase, active site IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 2.56073

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in DUSP2
  • Green Domain is present in both MAPK1 and DUSP2

 0.265
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: DUSP2

PTMResidueReference
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: DUSP2

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between MAPK1 and DUSP2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andDUSP2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and DUSP2 has 282 interactors of which there are 153 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for DUSP2-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 5.04
CDK2 CDK2: Cell division protein kinase 2 6.80 0.028
CRKL CRKL: Crk-like protein 0.461 0.029
JAK1 0.461 0.108
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.059
MSN MSN: Moesin 0.461 0.047
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.053
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.039
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.137
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.083
STK10 STK10: Uncharacterized protein STK10 0.385 0.293
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.881
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.047
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.032
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.0968
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.059
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.029
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.372 0.060
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.035
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.207
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.029
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.050
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.053
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.039
DOK1 DOK1: Docking protein 1 0.275 0.036
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.060
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.036
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.044
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.231
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.108
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.044
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.060
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.263
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.044
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.060
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.029
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.293
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.083
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.059
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.074
CCNH CCNH: Cyclin-H 0.225 0.028
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.137
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.050
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.137
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.041
CXorf9 N/A 0.188 0.074
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.083
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.044
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.067
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.044
RPS6KB1 N/A 0.188 0.074
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.028
FNBP1 N/A 0.188 0.038
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.035
NF2 NF2, SCH: Merlin 0.165 0.027
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.041
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.067
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.0308
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.037
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.065
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.027
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.027
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.027
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.139 0.083
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.028
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.036
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.044
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.0308
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.123
ATM ATM: Serine-protein kinase ATM 0.139 0.293
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.050
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.029
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.139 0.090
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.044
FYN N/A 0.137 0.231
VIL2 N/A 0.136 0.029
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.050
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.067
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.041
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.0308
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.114 0.0308
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.036
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.0308
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.028
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.036
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.096 0.0308
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.041
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.086 0.036
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.028
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.036
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.086 0.028
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.086 0.028
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.217
MAPKAPK5 N/A 0.083 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.265
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.217
MAPK15 N/A 0.083 0.265
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.027
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.083 0.108
ARHGEF3 ARHGEF3: Rho guanine nucleotide exchange factor 3 0.083 0.0278
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.038
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.078 0.035
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.078 0.047
PRKAA1 N/A 0.077 0.050
STK16 N/A 0.077 0.0308
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.083
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.027
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.027
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.027
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.027
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.027
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.027
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.027
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.027
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.027
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.027
RIN3 N/A 0.074 0.053
CCND3 CCND3: G1/S-specific cyclin-D3 0.074 0.083
CDK4 CDK4: Cell division protein kinase 4 0.069 0.028
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.035
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.039
CCNI CCNI: Cyclin-I 0.060 0.036
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.0331
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.225
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.177
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.046 0.044
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.030
CENTB1 CENTB1, KIAA0050: Centaurin-beta 1 0.044 0.053
SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 0.041 0.108
MYLIP MYLIP, BZF1, BM-023, PP5242: E3 ubiquitin-protein ligase MYLIP 0.041 0.039
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.030
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.036 0.039
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.036 0.047
CCND2 CCND2: G1/S-specific cyclin-D2 0.036 0.044
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.061
CRLF3 N/A 0.036 0.037
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.037
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.130
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.037
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.061
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.037
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.027
CCNG1 CCNG1, CCNG, CYCG1: Cyclin-G1 0.028 0.036
CCNL2 CCNL2, SB138: Cyclin-L2 0.028 0.074
CCNC CCNC: Cyclin-C 0.028 0.036
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.037
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.0308
2.15E-3
Total Score 27.40