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Evidence of Interaction Between MAPK1 and DUSP4

The interaction score between MAPK1 and DUSP4 is 7.18.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and DUSP4 = -0.07

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology
OrganismMAPK1 OrthologueDUSP4 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBL016W 1 YBR276C 0.113
bakers yeast YGR040W 0.096 YBR276C 0.113
bakers yeast YBL016W 1 YIL113W 0.113
bakers yeast YGR040W 0.096 YIL113W 0.113
bakers yeast YBL016W 1 YNL053W 0.113
  • Immunoprecipitation
  • CoLocalization

Get References From PubMed
bakers yeast YGR040W 0.096 YNL053W 0.113

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.119
Domains Domains present in MAPK1 and DUSP4:
Domains in MAPK1Domains in DUSP4
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase
IPR001763 Rhodanese-like
IPR000340 Dual specificity protein phosphatase
IPR008343 MAP kinase phosphatase

The Chi square scores for co-occurrence of domains that are present in MAPK1 and DUSP4 are listed below.

Domain 1Domain 2Chi Square
IPR003527 MAP kinase IPR008343 MAP kinase phosphatase 991.673
IPR003527 MAP kinase IPR000340 Dual specificity protein phosphatase 575.549
IPR008349 ERK1/2 MAP kinase IPR008343 MAP kinase phosphatase 440.473
IPR008349 ERK1/2 MAP kinase IPR000340 Dual specificity protein phosphatase 317.529
IPR003527 MAP kinase IPR001763 Rhodanese-like 312.614
IPR002290 Serine/threonine protein kinase IPR008343 MAP kinase phosphatase 147.067
IPR008349 ERK1/2 MAP kinase IPR001763 Rhodanese-like 137.552
IPR003527 MAP kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 128.642
IPR008271 Serine/threonine protein kinase, active site IPR008343 MAP kinase phosphatase 108.893
IPR002290 Serine/threonine protein kinase IPR000340 Dual specificity protein phosphatase 108.157
IPR008349 ERK1/2 MAP kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 89.8437
IPR002290 Serine/threonine protein kinase IPR001763 Rhodanese-like 87.68
IPR008271 Serine/threonine protein kinase, active site IPR000340 Dual specificity protein phosphatase 76.5901
IPR008271 Serine/threonine protein kinase, active site IPR001763 Rhodanese-like 75.5504
IPR000719 Protein kinase IPR008343 MAP kinase phosphatase 51.9861
IPR000719 Protein kinase IPR001763 Rhodanese-like 35.31
IPR000719 Protein kinase IPR000340 Dual specificity protein phosphatase 30.0934
IPR011009 Protein kinase-like IPR008343 MAP kinase phosphatase 21.8577
IPR011009 Protein kinase-like IPR000340 Dual specificity protein phosphatase 15.3476
IPR011009 Protein kinase-like IPR001763 Rhodanese-like 14.9678
IPR000719 Protein kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 14.0817
IPR002290 Serine/threonine protein kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 10.8808
IPR011009 Protein kinase-like IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 6.38835
IPR008271 Serine/threonine protein kinase, active site IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 2.56073

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in DUSP4
  • Green Domain is present in both MAPK1 and DUSP4

 0.265
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: DUSP4

PTMResidueReference
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: DUSP4

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between MAPK1 and DUSP4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andDUSP4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and DUSP4 has 113 interactors of which there are 47 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for DUSP4-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 4.44
CCNH CCNH: Cyclin-H 0.225 0.044
NF2 NF2, SCH: Merlin 0.165 0.027
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.0308
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.027
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.027
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.027
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.028
VIL2 N/A 0.136 0.035
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.028
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.041
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.0308
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.088 0.028
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.028
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.039
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.217
MAPKAPK5 N/A 0.083 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.265
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.217
MAPK15 N/A 0.083 0.265
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.027
LIMK2 LIMK2: LIM domain kinase 2 0.077 0.032
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.027
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.027
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.027
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.027
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.027
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.027
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.027
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.027
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.027
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.027
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.050
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.296
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.156
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.028
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.041
MYLIP MYLIP, BZF1, BM-023, PP5242: E3 ubiquitin-protein ligase MYLIP 0.041 0.032
CCND2 CCND2: G1/S-specific cyclin-D2 0.036 0.028
ITGB4 N/A 0.032 0.030
CCNG2 CCNG2: Cyclin-G2 0.028 0.0308
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
2.15E-3
Total Score 7.18