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Evidence of Interaction Between MAPK1 and DUSP8

The interaction score between MAPK1 and DUSP8 is 10.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and DUSP8 = 0.13

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology
OrganismMAPK1 OrthologueDUSP8 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBL016W 1 YBR276C 0.06
bakers yeast YBL016W 1 YIL113W 0.06
bakers yeast YBL016W 1 YNL053W 0.06
  • Immunoprecipitation
  • CoLocalization

Get References From PubMed
bakers yeast YGR040W 0.096 YBR276C 0.06
bakers yeast YGR040W 0.096 YIL113W 0.06
bakers yeast YGR040W 0.096 YNL053W 0.06
worm P39745 1 Q10038 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.119
Domains Domains present in MAPK1 and DUSP8:
Domains in MAPK1Domains in DUSP8
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase
IPR001763 Rhodanese-like
IPR000340 Dual specificity protein phosphatase
IPR008343 MAP kinase phosphatase

The Chi square scores for co-occurrence of domains that are present in MAPK1 and DUSP8 are listed below.

Domain 1Domain 2Chi Square
IPR003527 MAP kinase IPR008343 MAP kinase phosphatase 991.673
IPR003527 MAP kinase IPR000340 Dual specificity protein phosphatase 575.549
IPR008349 ERK1/2 MAP kinase IPR008343 MAP kinase phosphatase 440.473
IPR008349 ERK1/2 MAP kinase IPR000340 Dual specificity protein phosphatase 317.529
IPR003527 MAP kinase IPR001763 Rhodanese-like 312.614
IPR002290 Serine/threonine protein kinase IPR008343 MAP kinase phosphatase 147.067
IPR008349 ERK1/2 MAP kinase IPR001763 Rhodanese-like 137.552
IPR003527 MAP kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 128.642
IPR008271 Serine/threonine protein kinase, active site IPR008343 MAP kinase phosphatase 108.893
IPR002290 Serine/threonine protein kinase IPR000340 Dual specificity protein phosphatase 108.157
IPR008349 ERK1/2 MAP kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 89.8437
IPR002290 Serine/threonine protein kinase IPR001763 Rhodanese-like 87.68
IPR008271 Serine/threonine protein kinase, active site IPR000340 Dual specificity protein phosphatase 76.5901
IPR008271 Serine/threonine protein kinase, active site IPR001763 Rhodanese-like 75.5504
IPR000719 Protein kinase IPR008343 MAP kinase phosphatase 51.9861
IPR000719 Protein kinase IPR001763 Rhodanese-like 35.31
IPR000719 Protein kinase IPR000340 Dual specificity protein phosphatase 30.0934
IPR011009 Protein kinase-like IPR008343 MAP kinase phosphatase 21.8577
IPR011009 Protein kinase-like IPR000340 Dual specificity protein phosphatase 15.3476
IPR011009 Protein kinase-like IPR001763 Rhodanese-like 14.9678
IPR000719 Protein kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 14.0817
IPR002290 Serine/threonine protein kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 10.8808
IPR011009 Protein kinase-like IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 6.38835
IPR008271 Serine/threonine protein kinase, active site IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 2.56073

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in DUSP8
  • Green Domain is present in both MAPK1 and DUSP8

 0.265
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: DUSP8

PTMResidueReference
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: DUSP8

No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between MAPK1 and DUSP8 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andDUSP8. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and DUSP8 has 164 interactors of which there are 65 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for DUSP8-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 592.00
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.028
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.027
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.027
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.027
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.027
MAP2K5 N/A 0.165 0.027
NF2 NF2, SCH: Merlin 0.165 0.027
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.027
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.0308
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.027
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.027
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.060
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.060
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.044
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.074
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.036
CDK5 CDK5: Cell division protein kinase 5 0.114 0.060
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.028
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.036
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.028
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.036
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.028
PTPRZ1 N/A 0.090 0.053
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.060
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.044
CDK5R1 CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor 0.086 0.042
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.028
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.265
MAPKAPK5 N/A 0.083 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.265
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.265
MAPK15 N/A 0.083 0.265
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.027
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.0308
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.027
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.069 0.036
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.069 0.044
SPTAN1 N/A 0.062 0.042
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.074
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.044
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.060
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.158
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.036
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.156
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.028
GMFB GMFB: Glia maturation factor beta 0.038 0.044
YWHAH YWHAH, YWHA1: 14-3-3 protein eta 0.032 0.083
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.029
YWHAG YWHAG: 14-3-3 protein gamma 0.028 0.027
DOK6 DOK6: Uncharacterized protein DOK6 0.027 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.027
PTPN13 N/A 0.027 0.027
MT3 MT3: Metallothionein-3 0.026 0.0255
COTL1 COTL1, CLP: Coactosin-like protein 0.025 0.027
2.15E-3
Total Score 10.00