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Evidence of Interaction Between MAPK1 and PTK7

The interaction score between MAPK1 and PTK7 is 2.62.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in MAPK1 and PTK7:
Domains in MAPK1Domains in PTK7
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR003006 Immunoglobulin/major histocompatibility complex
IPR002011 Receptor tyrosine kinase, class II
IPR013151 Immunoglobulin.
IPR013098 I-set.

The Chi square scores for co-occurrence of domains that are present in MAPK1 and PTK7 are listed below.

Domain 1Domain 2Chi Square
IPR008271 Serine/threonine protein kinase, active site IPR007110 Immunoglobulin-like 49.9657
IPR008271 Serine/threonine protein kinase, active site IPR008266 Tyrosine protein kinase, active site 41.8291
IPR000719 Protein kinase IPR000719 Protein kinase 30.6895
IPR008271 Serine/threonine protein kinase, active site IPR003599 Immunoglobulin subtype 27.8873
IPR011009 Protein kinase-like IPR011009 Protein kinase-like 26.2215
IPR002290 Serine/threonine protein kinase IPR008266 Tyrosine protein kinase, active site 25.0766
IPR008271 Serine/threonine protein kinase, active site IPR003598 Immunoglobulin C-2 type 17.9033
IPR011009 Protein kinase-like IPR007110 Immunoglobulin-like 16.6203
IPR000719 Protein kinase IPR003006 Immunoglobulin/major histocompatibility complex 14.4874
IPR000719 Protein kinase IPR007110 Immunoglobulin-like 11.3335
IPR011009 Protein kinase-like IPR003599 Immunoglobulin subtype 8.86948
IPR008271 Serine/threonine protein kinase, active site IPR001245 Tyrosine protein kinase 8.08585
IPR000719 Protein kinase IPR008266 Tyrosine protein kinase, active site 6.98997
IPR008271 Serine/threonine protein kinase, active site IPR000719 Protein kinase 6.25263
IPR002290 Serine/threonine protein kinase IPR001245 Tyrosine protein kinase 5.09618
IPR008349 ERK1/2 MAP kinase IPR000719 Protein kinase 4.26499
IPR000719 Protein kinase IPR003599 Immunoglobulin subtype 3.60485
IPR000719 Protein kinase IPR011009 Protein kinase-like 2.94434
IPR003527 MAP kinase IPR000719 Protein kinase 2.81413
IPR011009 Protein kinase-like IPR013151 Immunoglobulin. 2.74789
IPR002290 Serine/threonine protein kinase IPR011009 Protein kinase-like 2.72953
IPR000719 Protein kinase IPR001245 Tyrosine protein kinase 2.31134
IPR008271 Serine/threonine protein kinase, active site IPR011009 Protein kinase-like 2.11823
IPR000719 Protein kinase IPR013098 I-set. 2.01835
IPR011009 Protein kinase-like IPR013098 I-set. 1.96932
IPR000719 Protein kinase IPR013151 Immunoglobulin. 1.81655
IPR003527 MAP kinase IPR001245 Tyrosine protein kinase 1.50703
IPR011009 Protein kinase-like IPR003598 Immunoglobulin C-2 type 1.32999
IPR000719 Protein kinase IPR002011 Receptor tyrosine kinase, class II 1.16654
IPR002290 Serine/threonine protein kinase IPR000719 Protein kinase 0.986464
IPR011009 Protein kinase-like IPR002011 Receptor tyrosine kinase, class II 0.315004
IPR011009 Protein kinase-like IPR001245 Tyrosine protein kinase 0.178275
IPR003527 MAP kinase IPR011009 Protein kinase-like 0.150555
IPR000719 Protein kinase IPR003598 Immunoglobulin C-2 type 0.142823
IPR008349 ERK1/2 MAP kinase IPR011009 Protein kinase-like 0.0192176
IPR011009 Protein kinase-like IPR009134 Vascular endothelial growth factor receptor, VEGFR 0.00926039
IPR011009 Protein kinase-like IPR008266 Tyrosine protein kinase, active site 0.00724826
IPR000719 Protein kinase IPR009134 Vascular endothelial growth factor receptor, VEGFR 0.0000462868
IPR008349 ERK1/2 MAP kinase IPR001245 Tyrosine protein kinase 0.0000302204

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in PTK7
  • Green Domain is present in both MAPK1 and PTK7

 0.022
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: PTK7

PTMResidueReference
N-linked 646 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: PTK7

No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between MAPK1 and PTK7 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andPTK7. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and PTK7 has 647 interactors of which there are 321 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for PTK7-Interactor (?)
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.051
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.051
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.051
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.051
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.051
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.051
PLEK PLEK, P47: Pleckstrin 0.515 0.051
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.051
CRKL CRKL: Crk-like protein 0.461 0.617
JAK1 0.461 0.617
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.617
MSN MSN: Moesin 0.461 0.051
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.617
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.051
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.617
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.617
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.051
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 1.53
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.617
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.051
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.051
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.617
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.617
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.617
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.051
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.617
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.617
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.617
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.051
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.051
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.051
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 1.53
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 1.53
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.051
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.307 0.051
DOK1 DOK1: Docking protein 1 0.275 0.051
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.617
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.617
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.051
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.051
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.617
HCK N/A 0.275 0.617
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.617
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.051
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.617
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.251 0.051
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.051
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.051
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.051
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.051
SH3BP5 N/A 0.225 0.051
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.617
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.617
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.051
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.051
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.617
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.051
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.192 0.051
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.051
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.617
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.617
CXorf9 N/A 0.188 0.051
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.188 0.051
FNBP1 N/A 0.188 0.051
GMIP GMIP: GEM-interacting protein 0.188 0.051
RIN1 RIN1: Ras and Rab interactor 1 0.171 1.53
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.617
PSD TYL: TYL protein 0.171 0.051
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.051
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.051
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.051
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.051
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.617
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.051
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.051
PSCD2 N/A 0.165 0.051
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 1.53
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 1.53
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.051
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 1.53
NF2 NF2, SCH: Merlin 0.165 0.051
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.051
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.617
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.051
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 1.53
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.051
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.617
SNCB SNCB: Beta-synuclein 0.152 0.051
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.617
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.051
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.051
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.051
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.051
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.051
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.617
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.617
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.617
STAT3 0.148 1.53
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.051
ELMO1 N/A 0.148 0.051
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.051
ARHGEF7 N/A 0.148 0.051
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.051
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.051
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.617
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.617
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.051
FYN N/A 0.137 0.0288
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.051
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.051
RDX RDX: Radixin 0.136 0.051
VIL2 N/A 0.136 0.051
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.051
STMN1 STMN1, LAP18, OP18: Stathmin 0.136 0.051
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.051
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.051
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 1.53
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.051
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.051
CDC37 CDC37: Hsp90 co-chaperone Cdc37 0.116 0.051
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.051
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.051
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.051
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.051
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.617
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.617
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.051
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.051
STMN2 STMN2, SCG10, SCGN10: Stathmin-2 0.111 0.051
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.617
PLD2 PLD2: Phospholipase D2 0.111 0.051
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.617
BMX N/A 0.110 0.617
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.051
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.051
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.109 0.051
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.051
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.051
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.617
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 1.53
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.617
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.051
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.051
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.051
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.051
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.051
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.051
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.617
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.051
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.617
PLD1 PLD1: Phospholipase D1 0.097 0.051
DAB1 DAB1: Disabled homolog 1 0.097 0.051
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.051
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.051
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.051
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.051
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.051
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.051
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.051
PTPRZ1 N/A 0.090 0.051
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.617
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.051
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.087 0.051
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.051
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.051
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.083 0.0288
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.051
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.051
LCP1 LCP1, PLS2: Plastin-2 0.078 0.051
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.051
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.051
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.051
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.051
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.051
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.051
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.051
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.051
RIN3 N/A 0.074 0.0288
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.051
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.051
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.071 0.051
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.070 0.051
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.051
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.051
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.051
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.063 0.051
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.051
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.051
SPTAN1 N/A 0.062 0.051
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.062 0.051
GRLF1 N/A 0.062 0.051
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.051
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.051
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.051
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.051
TP73 TP73, P73: Tumor protein p73 0.055 0.051
EIF4EBP1 EIF4EBP1: Eukaryotic translation initiation factor 4E-binding protein 1 0.053 0.051
PPP1R14C PPP1R14C, KEPI: Protein phosphatase 1 regulatory subunit 14C 0.051 0.051
GRB10 N/A 0.051 0.617
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 1.53
PPP1R1B PPP1R1B, DARPP32: Protein phosphatase 1 regulatory subunit 1B 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 1.53
CRK CRK: Proto-oncogene C-crk 0.051 1.53
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.051 0.051
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.051
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.051
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.051
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.051
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.051
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.051
EDA N/A 0.049 0.051
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.051
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.051
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.051
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.051
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.051
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.048 0.051
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.046 0.051
PPP1R14A PPP1R14A, CPI17, PPP1INL: Protein phosphatase 1 regulatory subunit 14A 0.046 0.051
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 1.53
VAV2 VAV2: Uncharacterized protein VAV2 0.046 1.53
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.051
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.046 0.051
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.051
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.051
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.045 0.051
CGA CGA: Glycoprotein hormones alpha chain precursor 0.045 0.051
TSHB TSHB: Thyrotropin subunit beta precursor 0.045 0.051
FSHB FSHB: Follitropin subunit beta precursor 0.045 0.051
LHB LHB: Lutropin subunit beta precursor 0.045 0.051
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.045 0.051
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.051
MYO3A MYO3A: Myosin IIIA 0.044 0.051
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.051
CNN3 CNN3: Calponin-3 0.044 0.051
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.051
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.051
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.051
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.043 0.051
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.051
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.041 0.051
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.051
INHA INHA: Inhibin alpha chain precursor 0.041 0.051
KRT8 KRT8, CYK8: Keratin, type II cytoskeletal 8 0.041 0.051
FGF5 FGF5: Fibroblast growth factor 5 precursor 0.041 0.051
NDP NDP: Norrin precursor 0.041 0.051
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.041 0.051
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.051
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.051
SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 0.041 0.0288
FGF9 FGF9: Glia-activating factor precursor 0.041 0.051
BMP7 BMP7, OP1: Bone morphogenetic protein 7 precursor 0.041 0.051
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.051
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.051
MYH9 MYH9: Myosin-9 0.038 0.051
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.051
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.051
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.051
GHR GHR: Growth hormone receptor precursor 0.037 0.051
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.051
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.051
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.051
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.051
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.051
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.051
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.051
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.051
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.051
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.051
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.051
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.051
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.051
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.0338 0.051
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.051
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.051
PRLR PRLR: Prolactin receptor precursor 0.033 0.051
F3 F3: Tissue factor precursor 0.032 0.051
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.051
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.051
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.051
ITGB4 N/A 0.032 0.051
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.051
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.051
RYR2 RYR2: Ryanodine receptor 2 0.031 0.051
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.030 0.051
PPP1R1A PPP1R1A, IPP1: Protein phosphatase 1 regulatory subunit 1A 0.030 0.051
GJA5 GJA5: Gap junction alpha-5 protein 0.030 0.051
PEBP1 PEBP1, PBP, PEBP: Phosphatidylethanolamine-binding protein 1 0.030 0.051
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.051
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.051
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.051
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.051
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.051
THOP1 THOP1: Thimet oligopeptidase 0.029 0.051
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.029 0.027
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.029 0.027
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.051
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.051
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.028 0.051
VAV3 VAV3: Protein vav-3 0.028 0.0288
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.0288
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.0288
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.0288
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.0288
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.0288
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.051
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.051
CD69 CD69: Early activation antigen CD69 0.027 0.051
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.051
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.051
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.025 0.051
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.025 0.051
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.051
F5 F5: Coagulation factor V precursor 0.025 0.051
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.051
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.051
MYO18A 0.025 0.051
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.051
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.051
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.025 0.051
0.299
Total Score 2.62