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Evidence of Interaction Between MAPK1 and IKBKE

The interaction score between MAPK1 and IKBKE is 1.79.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismMAPK1 OrthologueIKBKE OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly P40417 1 Q8INU8 0.194

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and IKBKE:
Domains in MAPK1Domains in IKBKE
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site

The Chi square scores for co-occurrence of domains that are present in MAPK1 and IKBKE are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR000719 Protein kinase 30.6895
IPR011009 Protein kinase-like IPR011009 Protein kinase-like 26.2215
IPR003527 MAP kinase IPR008271 Serine/threonine protein kinase, active site 20.8159
IPR008349 ERK1/2 MAP kinase IPR008271 Serine/threonine protein kinase, active site 17.555
IPR008349 ERK1/2 MAP kinase IPR002290 Serine/threonine protein kinase 13.3941
IPR003527 MAP kinase IPR002290 Serine/threonine protein kinase 10.9612
IPR002290 Serine/threonine protein kinase IPR008271 Serine/threonine protein kinase, active site 8.88805
IPR000719 Protein kinase IPR008271 Serine/threonine protein kinase, active site 6.25263
IPR008271 Serine/threonine protein kinase, active site IPR008271 Serine/threonine protein kinase, active site 5.82656
IPR008349 ERK1/2 MAP kinase IPR000719 Protein kinase 4.26499
IPR000719 Protein kinase IPR011009 Protein kinase-like 2.94434
IPR003527 MAP kinase IPR000719 Protein kinase 2.81413
IPR002290 Serine/threonine protein kinase IPR011009 Protein kinase-like 2.72953
IPR011009 Protein kinase-like IPR008271 Serine/threonine protein kinase, active site 2.11823
IPR000719 Protein kinase IPR002290 Serine/threonine protein kinase 0.986464
IPR002290 Serine/threonine protein kinase IPR002290 Serine/threonine protein kinase 0.532451
IPR003527 MAP kinase IPR011009 Protein kinase-like 0.150555
IPR008349 ERK1/2 MAP kinase IPR011009 Protein kinase-like 0.0192176

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in IKBKE
  • Green Domain is present in both MAPK1 and IKBKE

 0.022
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: IKBKE

PTMResidueReference
Phosphoserine 172 HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: IKBKE

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between MAPK1 and IKBKE that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andIKBKE. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and IKBKE has 184 interactors of which there are 178 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for IKBKE-Interactor (?)
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.046
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.046
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.046
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.046
HSP90AA1 Hsp89-alpha-delta-N 3.95 9.44
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.046
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.051
PLEK PLEK, P47: Pleckstrin 0.515 0.051
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.046
CRKL CRKL: Crk-like protein 0.461 0.046
JAK1 0.461 0.046
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.046
MSN MSN: Moesin 0.461 0.046
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.046
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.046
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.051
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.051
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.046
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.046
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.372 0.046
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.046
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.051
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.046
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.046
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.046
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.046
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.372 0.046
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.046
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.046
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.046
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.046
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.051
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.051
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.051
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.307 0.051
DOK1 DOK1: Docking protein 1 0.275 0.046
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.046
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.046
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.046
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.046
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.046
HCK N/A 0.275 0.046
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.275 0.046
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.046
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.046
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.275 0.046
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.051
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.251 0.051
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.051
SH3BP5 N/A 0.225 0.046
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.046
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.051
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.046
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.046
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.046
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.046
CCNH CCNH: Cyclin-H 0.225 0.046
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.208 0.026
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.051
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.051
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.051
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.174 0.051
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 22.10
PSD TYL: TYL protein 0.171 0.046
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.046
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.046
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.046
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.046
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.046
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.051
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.051
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.051
PSCD2 N/A 0.165 0.051
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.051
NF2 NF2, SCH: Merlin 0.165 0.051
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.051
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.051
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.051
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.051
SNCB SNCB: Beta-synuclein 0.152 0.051
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.051
CREB1 CREB1: cAMP response element-binding protein 0.148 0.046
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.046
CCNT2 CCNT2: Cyclin-T2 0.148 0.046
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.046
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.046
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.046
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.051
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.046
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.046
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.046
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.046
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.046
ELMO1 N/A 0.148 0.046
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.046
ARHGEF7 N/A 0.148 0.046
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.046
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.046
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.046
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.046
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.046
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.046
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.046
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.046
RDX RDX: Radixin 0.136 0.046
VIL2 N/A 0.136 0.046
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.046
CCNB1 Cyclin B1 0.136 0.046
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.046
STMN1 STMN1, LAP18, OP18: Stathmin 0.136 0.046
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.051
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.051
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.051
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.051
CDC37 CDC37: Hsp90 co-chaperone Cdc37 0.116 0.046
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.046
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.051
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.046
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.046
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.046
STMN2 STMN2, SCG10, SCGN10: Stathmin-2 0.111 0.046
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.046
PLD2 PLD2: Phospholipase D2 0.111 0.046
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.051
BMX N/A 0.110 0.051
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.051
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.109 0.051
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.051
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.051
HMGA2 HMGA2, HMGIC: High mobility group protein HMGI-C 0.109 0.051
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.051
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.051
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.051
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.046
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.051
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.051
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.046
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.046
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.046
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.046
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.046
PLD1 PLD1: Phospholipase D1 0.097 0.046
DAB1 DAB1: Disabled homolog 1 0.097 0.046
TST TST: Thiosulfate sulfurtransferase 0.097 0.051
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.046
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.046
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.046
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.088 0.046
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.046
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.046
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.046
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.046
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.073 0.046
GABRR1 N/A 0.0727 0.051
CHAT CHAT: Choline O-acetyltransferase 0.062 0.046
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.046
GLRA1 N/A 0.058 0.046
PFKFB2 PFKFB2: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.057 0.046
EIF4EBP1 EIF4EBP1: Eukaryotic translation initiation factor 4E-binding protein 1 0.053 0.046
PPP1R14C PPP1R14C, KEPI: Protein phosphatase 1 regulatory subunit 14C 0.051 0.051
GRB10 N/A 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
PPP1R1B PPP1R1B, DARPP32: Protein phosphatase 1 regulatory subunit 1B 0.051 0.051
TH TH, TYH: Tyrosine 3-monooxygenase 0.046 0.046
PPP1R14A PPP1R14A, CPI17, PPP1INL: Protein phosphatase 1 regulatory subunit 14A 0.046 0.046
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.046 0.046
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.045 0.051
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.041 0.046
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.046
PFKFB1 N/A 0.037 0.046
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.051
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.0338 0.051
TPH1 N/A 0.0338 0.051
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.030 0.051
PPP1R1A PPP1R1A, IPP1: Protein phosphatase 1 regulatory subunit 1A 0.030 0.051
GJA5 GJA5: Gap junction alpha-5 protein 0.030 0.051
PEBP1 PEBP1, PBP, PEBP: Phosphatidylethanolamine-binding protein 1 0.030 0.046
0.228
Total Score 1.79