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Evidence of Interaction Between RFC4 and TAF9

The interaction score between RFC4 and TAF9 is 31.40.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RFC4 and TAF9 = 0.76

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology N/A N/A
Domains Domains present in RFC4 and TAF9:
Domains in RFC4Domains in TAF9
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR008921 DNA polymerase III clamp loader subunit, C-terminal
IPR000862 RFC
IPR013748 Replication factor C
IPR003959 AAA ATPase, central region
IPR000623 Shikimate kinase
IPR011769 Ad_Ct_kin_N.

The Chi square scores for co-occurrence of domains that are present in RFC4 and TAF9 are listed below.

Domain 1Domain 2Chi Square
IPR000862 RFC IPR003959 AAA ATPase, central region 182.174
IPR003959 AAA ATPase, central region IPR003959 AAA ATPase, central region 167.459
IPR003593 AAA ATPase IPR003959 AAA ATPase, central region 133.351

The background colour of the table refers to:

  • Blue Domain is only present in RFC4
  • Yellow Domain is only present in TAF9
  • Green Domain is present in both RFC4 and TAF9

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: TAF9

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between RFC4 and TAF9 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andTAF9. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and TAF9 has 89 interactors of which there are 54 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for TAF9-Interactor (?)
RFC3 RFC3: Replication factor C subunit 3 1.05E4 0.137
RFC5 RFC5: Replication factor C subunit 5 691.00 0.137
RFC2 RFC2: Replication factor C subunit 2 62.80 0.027
PCNA PCNA: Proliferating cell nuclear antigen 54.70 0.108
MCM6 MCM6: DNA replication licensing factor MCM6 0.620 0.108
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.263 0.293
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.207 0.027
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.207 0.108
MCM3 MCM3: DNA replication licensing factor MCM3 0.207 0.231
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.207 0.108
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.207 0.065
MCM5 MCM5, CDC46: DNA replication licensing factor MCM5 0.207 0.108
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 0.207 0.108
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.137 0.042
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.123 0.0255
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.123 0.083
RUVBL1 RUVBL1, NMP238, TIP49, TIP49A: RuvB-like 1 0.123 0.137
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.123 0.083
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.117 0.042
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.108 0.108
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.0968 0.027
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.0968 0.042
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.0968 0.065
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.074 0.083
RUVBL2 RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2 0.074 0.067
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.074 0.0255
SRP54 SRP54: Signal recognition particle 54 kDa protein 0.074 0.083
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.074 0.083
ATAD3A ATAD3A: ATPase family AAA domain-containing protein 3A 0.074 0.083
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.074 0.042
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.074 0.083
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.074 0.042
PSMC3 PSMC3, TBP1: 26S protease regulatory subunit 6A 0.074 0.083
MDN1 MDN1, KIAA0301: Midasin 0.060 0.083
NARS NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic 0.060 0.042
EIF1AX EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal 0.060 0.0255
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.059 0.059
CSE1L CSE1L, CAS, XPO2: Exportin-2 0.053 0.059
CNAP1 NCAPD2, CAPD2, CNAP1, KIAA0159: Condensin complex subunit 1 0.053 0.0278
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.047 0.065
VCP VCP: Transitional endoplasmic reticulum ATPase 0.044 0.067
BCS1L BCS1L, BCS1: Mitochondrial chaperone BCS1 0.044 0.050
SRPR SRPR: Uncharacterized protein SRPR 0.041 0.041
VPS4A VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A 0.036 0.041
NUBP1 NUBP1, NBP, NBP1: Nucleotide-binding protein 1 0.036 0.041
PEX1 PEX1: Peroxisome biogenesis factor 1 0.036 0.041
XAB1 XAB1, MBDIN, HUSSY-23: XPA-binding protein 1 0.0331 0.083
VPS4B VPS4B, SKD1, VPS42: Vacuolar protein sorting-associating protein 4B 0.028 0.041
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.027
ITGB3BP N/A 0.027 0.027
PRSS15 LONP1, PRSS15: Lon protease homolog, mitochondrial precursor 0.027 0.083
AFG3L2 AFG3L2: AFG3-like protein 2 0.027 0.083
CLPX CLPX: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial pr 0.027 0.083
DNAH11 N/A 0.027 0.027
0.572
Total Score 31.40