PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between RFC4 and CHTF18

The interaction score between RFC4 and CHTF18 is 49.10.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	RFC4 Orthologue		CHTF18 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YJR068W	1	YMR078C	1	Immunoprecipitation AffinityCaptureWestern Get References From PubMed
worm	P53016	1	Q21350	1
fly	Q9VX15	1	Q8IQ05	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

No domains were used in calculating likelihood of interaction

1.48E-3

Post-translational Modifications

Protein: RFC4

PTM	Residue	Reference

Protein: CHTF18

PTM	Residue	Reference
Phosphorylation	871	PubMed, HPRD

Localisation

Protein: RFC4

Localisation	Reference
Nucleoplasm	HPRD

Protein: CHTF18

Localisation	Reference
Nucleus	HPRD

Transitive Score

The common interactors between RFC4 and CHTF18 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andCHTF18. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and CHTF18 has 789 interactors of which there are 20 common interactors.

Common Interactor	Name of Common Interactor	Score for RFC4-Interactor (?)	Score for CHTF18-Interactor (?)
RFC3	RFC3: Replication factor C subunit 3	1.05E4	0.354
RFC5	RFC5: Replication factor C subunit 5	691.00	0.354
RFC2	RFC2: Replication factor C subunit 2	62.80	0.354
PCNA	PCNA: Proliferating cell nuclear antigen	54.70	3.39
IMPDH2	IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2	3.89	0.025
GART	GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include	0.354	0.025
LAMR1	RPSA, LAMBR, LAMR1: 40S ribosomal protein SA	0.221	0.025
TRIP13	TRIP13: Thyroid receptor-interacting protein 13	0.123	0.025
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.123	0.025
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.123	0.025
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.083	0.028
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.074	0.025
PSMC2	PSMC2, MSS1: 26S protease regulatory subunit 7	0.074	0.025
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.074	0.025
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.067	0.028
MDN1	MDN1, KIAA0301: Midasin	0.060	0.025
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.060	0.025
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.059	0.028
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.044	0.025
SRPR	SRPR: Uncharacterized protein SRPR	0.041	0.028

0.347

Total Score

49.10