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Evidence of Interaction Between RFC4 and IMPDH2

The interaction score between RFC4 and IMPDH2 is 3.36.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RFC4 and IMPDH2 = 0.83

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismRFC4 OrthologueIMPDH2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR068W 1 YAR073W 0.116
bakers yeast YJR068W 1 YHR216W 0.857
bakers yeast YJR068W 1 YLR432W 1
  • AffinityCaptureMS

Get References From PubMed
bakers yeast YJR068W 1 YML056C 1
worm P53016 1 Q9GZH3 0.498
fly Q9VX15 1 Q07152 0.356

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications

Protein: RFC4

PTMResidueReference

Protein: IMPDH2

PTMResidueReference
Phosphotyrosine 400 HPRD
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: IMPDH2

No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between RFC4 and IMPDH2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andIMPDH2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and IMPDH2 has 854 interactors of which there are 36 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for IMPDH2-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 54.70 10.50
RFC1 N/A 9.26 1.82
KPNA6 N/A 2.37 0.108
KPNA5 KPNA5: Importin subunit alpha-6 1.18 0.065
KPNA1 KPNA1, RCH2: Importin subunit alpha-1 0.647 0.096
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.612 0.040
IMPDH1 IMPDH1: Uncharacterized protein IMPDH1 0.593 3.01
CHTF18 RUVBL, CHTF18: Protein CTF18 homolog. 0.354 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.354 0.025
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.263 3.89
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.221 34.20
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.207 0.066
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.207 0.066
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.207 0.066
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.207 0.066
MCM3 MCM3: DNA replication licensing factor MCM3 0.207 0.141
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.123 0.078
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.123 0.078
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.123 0.063
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.0968 0.033
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.0968 0.066
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.083 0.070
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.074 0.078
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.074 0.078
MDN1 MDN1, KIAA0301: Midasin 0.060 0.078
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.060 0.063
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.059 0.307
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.059 0.040
CCNB1 Cyclin B1 0.051 0.040
GCLC GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit 0.044 0.408
VCP VCP: Transitional endoplasmic reticulum ATPase 0.044 0.063
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.042 0.066
SRPR SRPR: Uncharacterized protein SRPR 0.041 0.052
ITGB3BP N/A 0.027 0.027
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.030
GMNN GMNN: Geminin 0.027 0.025
2.15E-3
Total Score 3.36