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Evidence of Interaction Between RFC4 and LIG1

The interaction score between RFC4 and LIG1 is 1.86.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RFC4 and LIG1 = 0.87

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismRFC4 OrthologueLIG1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR068W 1 YDL164C 1
worm P53016 1 Q27474 1
fly Q9VX15 1 Q960P4 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 8.25E-4
Post-translational Modifications

Protein: RFC4

PTMResidueReference

Protein: LIG1

PTMResidueReference
Phosphorylation 66 PubMed, HPRD
Phosphorylation 76 PubMed, HPRD
Phosphorylation 141 PubMed, HPRD
Phosphorylation 195 PubMed, HPRD
Phosphorylation 911 PubMed, HPRD
Phosphoserine 66 HPRD
Phosphoserine 76 HPRD
Phosphoserine 141 HPRD
Phosphoserine 911 HPRD
Phosphothreonine 195 HPRD
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: LIG1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD
Transitive Score

The common interactors between RFC4 and LIG1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andLIG1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and LIG1 has 892 interactors of which there are 40 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for LIG1-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 54.70 73.00
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 3.89 0.066
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.612 0.129
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.221 0.066
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.207 0.129
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.207 0.276
MCM3 MCM3: DNA replication licensing factor MCM3 0.207 0.276
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.207 0.129
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.207 0.129
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.123 0.129
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.123 0.066
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.123 0.040
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.0968 0.078
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.0968 0.129
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.083 0.070
SMC4L1 N/A 0.082 0.027
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.082 0.027
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.074 0.032
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.074 0.040
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.074 0.032
FEN1 FEN1, RAD2: Flap endonuclease 1 0.0739 12.60
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.067 0.087
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.060 0.063
MDN1 MDN1, KIAA0301: Midasin 0.060 0.078
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.059 0.307
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.059 0.129
CCNB1 Cyclin B1 0.051 0.129
VCP VCP: Transitional endoplasmic reticulum ATPase 0.044 0.032
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.042 0.129
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.027 0.053
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.025
MCM10 N/A 0.027 0.027
C22orf18 N/A 0.027 0.027
TMPO N/A 0.027 0.027
RAD51AP1 N/A 0.027 0.027
ZWINT N/A 0.027 0.027
GMNN GMNN: Geminin 0.027 0.025
DBF4 DBF4, ASK: Protein DBF4 homolog 0.027 0.025
C18orf56 N/A 0.027 0.027
ITGB3BP N/A 0.027 0.027
0.572
Total Score 1.86