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Evidence of Interaction Between RFC4 and POLD1

The interaction score between RFC4 and POLD1 is 1.86.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RFC4 and POLD1 = 0.80

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027
Orthology
OrganismRFC4 OrthologuePOLD1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR068W 1 YDL102W 1
worm P53016 1 P90829 1
fly Q9VX15 1 P54358 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3
Domains No domains were used in calculating likelihood of interaction 8.25E-4
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: POLD1

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between RFC4 and POLD1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andPOLD1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and POLD1 has 67 interactors of which there are 10 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for POLD1-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 54.70 0.263
SMC4L1 N/A 0.082 0.027
MDN1 MDN1, KIAA0301: Midasin 0.060 0.060
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.042 0.081
HMMR HMMR: Hyaluronan-mediated motility receptor 0.027 0.027
C22orf18 N/A 0.027 0.082
RAD51AP1 N/A 0.027 0.027
ZWINT N/A 0.027 0.027
GMNN GMNN: Geminin 0.027 0.027
C18orf56 N/A 0.027 0.027
0.572
Total Score 1.86