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Evidence of Interaction Between RFC4 and RFC2

The interaction score between RFC4 and RFC2 is 1.43E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismRFC4 OrthologueRFC2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR068W 1 YOL094C 1
  • Immunoprecipitation
  • Other
  • AffinityCaptureMS
  • CoPurification

Get References From PubMed
worm P53016 1 O44175 1
fly Q9VX15 1 P53034 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in RFC4 and RFC2:
Domains in RFC4Domains in RFC2
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR008921 DNA polymerase III clamp loader subunit, C-terminal
IPR000862 RFC
IPR013748 Replication factor C
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR000862 RFC

The Chi square scores for co-occurrence of domains that are present in RFC4 and RFC2 are listed below.

Domain 1Domain 2Chi Square
IPR008921 DNA polymerase III clamp loader subunit, C-terminal IPR000862 RFC 1447.35
IPR000862 RFC IPR000862 RFC 1295.13
IPR013748 Replication factor C IPR000862 RFC 1125.48
IPR003959 AAA ATPase, central region IPR000862 RFC 182.174
IPR003959 AAA ATPase, central region IPR003959 AAA ATPase, central region 167.459
IPR003593 AAA ATPase IPR003959 AAA ATPase, central region 133.351
IPR003593 AAA ATPase IPR000862 RFC 128.851
IPR003593 AAA ATPase IPR003593 AAA ATPase 89.0695

The background colour of the table refers to:

  • Blue Domain is only present in RFC4
  • Yellow Domain is only present in RFC2
  • Green Domain is present in both RFC4 and RFC2

 0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: RFC2

LocalisationReference
Nucleolus HPRD
Nucleoplasm HPRD
Transitive Score

The common interactors between RFC4 and RFC2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andRFC2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and RFC2 has 46 interactors of which there are 20 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for RFC2-Interactor (?)
RFC3 RFC3: Replication factor C subunit 3 1.05E4 62.80
RFC5 RFC5: Replication factor C subunit 5 691.00 319.00
PCNA PCNA: Proliferating cell nuclear antigen 54.70 4.98
RFC1 N/A 9.26 0.354
RAD17 RAD17, R24L: Cell cycle checkpoint protein RAD17 4.78 0.0258
ASF1B ASF1B: Histone chaperone ASF1B 2.15 0.196
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.354 0.354
CHTF18 RUVBL, CHTF18: Protein CTF18 homolog. 0.354 0.354
ASF1A ASF1A, CGI-98, HSPC146: Histone chaperone ASF1A 0.203 0.039
TAF9 AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6 0.137 0.027
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.137 0.027
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.0968 3.48
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.083 0.027
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.067 0.027
SRPR SRPR: Uncharacterized protein SRPR 0.041 0.027
RFC1 RFC1, RFC140: Replication factor C subunit 1 0.0288 0.0288
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
RAD51L1 RAD51L1, RAD51B, REC2: DNA repair protein RAD51 homolog 2 0.027 0.027
DNAH11 N/A 0.027 0.027
RAD51L3 RAD51L3, RAD51D: DNA repair protein RAD51 homolog 4 0.027 0.027
0.572
Total Score 1.43E4