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Evidence of Interaction Between RFC4 and RFC1

The interaction score between RFC4 and RFC1 is 2.12E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RFC4 and RFC1 = 0.73

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.013
Orthology
OrganismRFC4 OrthologueRFC1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR068W 1 YOR217W 1
  • SyntheticLethal
  • CoPurification

Get References From PubMed

worm P53016 1 Q18841 1
  • Y2H

Get References From PubMed

fly Q9VX15 1 P35600 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

3.01
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: RFC1

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between RFC4 and RFC1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andRFC1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and RFC1 has 74 interactors of which there are 12 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for RFC1-Interactor (?)
RFC3 RFC3: Replication factor C subunit 3 1.05E4 9.26
RFC5 RFC5: Replication factor C subunit 5 691.00 1.10
RFC2 RFC2: Replication factor C subunit 2 62.80 0.354
PCNA PCNA: Proliferating cell nuclear antigen 54.70 80.90
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 3.89 1.82
ASF1B ASF1B: Histone chaperone ASF1B 2.15 1.10
IMPDH1 IMPDH1: Uncharacterized protein IMPDH1 0.593 0.593
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.263 0.074
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.221 0.221
ASF1A ASF1A, CGI-98, HSPC146: Histone chaperone ASF1A 0.203 0.221
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.108 0.0255
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.059 0.137
0.572
Total Score 2.12E3