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Evidence of Interaction Between RFC4 and FEN1

The interaction score between RFC4 and FEN1 is 16.90.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RFC4 and FEN1 = 0.90

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.082
Orthology
OrganismRFC4 OrthologueFEN1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR068W 1 YKL113C 1
worm P53016 1 Q9N3T2 1
fly Q9VX15 1 O96830 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3
Domains No domains were used in calculating likelihood of interaction N/A
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between RFC4 and FEN1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andFEN1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and FEN1 has 145 interactors of which there are 34 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for FEN1-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 54.70 38.00
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.207 0.0479
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.207 0.144
MCM3 MCM3: DNA replication licensing factor MCM3 0.207 0.144
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.207 0.144
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.207 0.0479
MCM5 MCM5, CDC46: DNA replication licensing factor MCM5 0.207 0.0739
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 0.207 0.0739
SMC4L1 N/A 0.082 0.082
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.082 0.082
Pfs2 GINS2, PSF2, CGI-122, DC5, HSPC037: DNA replication complex GINS protein PSF2 0.0739 0.0739
RP4-691N24.2 GINS1, KIAA0186, PSF1: DNA replication complex GINS protein PSF1 0.0739 0.0739
CKS2 CKS2: Cyclin-dependent kinases regulatory subunit 2 0.0739 0.0739
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.059 0.025
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.051 0.0739
CCNB1 Cyclin B1 0.051 0.0479
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.027 0.053
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.025
CKAP2 CKAP2, LB1, TMAP: Cytoskeleton-associated protein 2 0.027 0.027
HMMR HMMR: Hyaluronan-mediated motility receptor 0.027 0.082
TPRKB TPRKB, CGI-121, My019: TP53RK-binding protein 0.027 0.027
MCM10 N/A 0.027 0.027
C22orf18 N/A 0.027 0.027
TMPO N/A 0.027 0.027
RAD51AP1 N/A 0.027 0.027
ZWINT N/A 0.027 0.082
GMNN GMNN: Geminin 0.027 0.160
DBF4 DBF4, ASK: Protein DBF4 homolog 0.027 0.025
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.027 0.027
C18orf56 N/A 0.027 0.082
C21orf45 C21orf45, C21orf46, FASP1: Uncharacterized protein C21orf45 0.027 0.027
CDCA8 CDCA8, PESCRG3: Borealin 0.027 0.027
CDCA3 CDCA3, C8, GRCC8, TOME1: Cell division cycle-associated protein 3 0.027 0.027
CCNF CCNF: G2/mitotic-specific cyclin-F 0.027 0.027
0.572
Total Score 16.90