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Evidence of Interaction Between RFC4 and CHAF1A

The interaction score between RFC4 and CHAF1A is 5.63.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RFC4 and CHAF1A = 0.85

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027
Orthology
OrganismRFC4 OrthologueCHAF1A OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P53016 1 Q9U380 1
fly Q9VX15 1 Q9W3D1 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3
Domains No domains were used in calculating likelihood of interaction N/A
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between RFC4 and CHAF1A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andCHAF1A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and CHAF1A has 101 interactors of which there are 22 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for CHAF1A-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 54.70 0.0479
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.207 0.0479
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.207 0.0479
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.207 0.0479
MCM3 MCM3: DNA replication licensing factor MCM3 0.207 0.0479
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.108 0.027
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.082 0.027
SMC4L1 N/A 0.082 0.027
FEN1 FEN1, RAD2: Flap endonuclease 1 0.0739 0.0479
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.059 0.025
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.042 0.0479
DBF4 DBF4, ASK: Protein DBF4 homolog 0.027 0.025
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.027 0.027
C18orf56 N/A 0.027 0.027
ITGB3BP N/A 0.027 0.027
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.053
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.027 0.025
TPRKB TPRKB, CGI-121, My019: TP53RK-binding protein 0.027 0.027
TMPO N/A 0.027 0.027
ZWINT N/A 0.027 0.027
GMNN GMNN: Geminin 0.027 0.053
RAD51AP1 N/A 0.027 0.027
0.572
Total Score 5.63