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Evidence of Interaction Between RFC4 and PRKDC

The interaction score between RFC4 and PRKDC is 7.09.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RFC4 and PRKDC = 0.81

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology N/A N/A
Domains Domains present in RFC4 and PRKDC:
Domains in RFC4Domains in PRKDC
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR008921 DNA polymerase III clamp loader subunit, C-terminal
IPR000862 RFC
IPR013748 Replication factor C
IPR000403 Phosphatidylinositol 3- and 4-kinase
IPR003151 PIK-related kinase, FAT
IPR003152 PIK-related kinase, FATC
IPR002885 PPR repeat
IPR000357 HEAT
IPR011989 ARM-like.
IPR011990 TPR-like_helical.
IPR012582 NUC194.

The Chi square scores for co-occurrence of domains that are present in RFC4 and PRKDC are listed below.

Domain 1Domain 2Chi Square
IPR003959 AAA ATPase, central region IPR011989 ARM-like. 1.29744
IPR003593 AAA ATPase IPR011989 ARM-like. 0.00003165

The background colour of the table refers to:

  • Blue Domain is only present in RFC4
  • Yellow Domain is only present in PRKDC
  • Green Domain is present in both RFC4 and PRKDC

 5.38E-3
Post-translational Modifications

Protein: RFC4

PTMResidueReference

Protein: PRKDC

PTMResidueReference
Phosphorylation 480 PubMed, HPRD
Phosphorylation 492 PubMed, HPRD
Phosphorylation 505 PubMed, HPRD
Phosphorylation 2609 PubMed, HPRD
Phosphorylation 2612 PubMed, HPRD
Phosphorylation 2620 PubMed, HPRD
Phosphorylation 2624 PubMed, HPRD
Phosphorylation 2638 PubMed, HPRD
Phosphorylation 2647 PubMed, HPRD
Phosphorylation 3205 PubMed, HPRD
Phosphoserine 2612 PubMed, HPRD
Phosphoserine 3205 HPRD
Phosphothreonine 2609 PubMed, HPRD
Phosphothreonine 2638 PubMed, HPRD
Phosphothreonine 2647 PubMed, HPRD
Proteolytic Cleavage 2020 PubMed, HPRD
Proteolytic Cleavage 2699 PubMed, HPRD
Proteolytic Cleavage 2713 PubMed, HPRD
Proteolytic Cleavage 3211 PubMed, HPRD
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: PRKDC

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between RFC4 and PRKDC that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andPRKDC. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and PRKDC has 1692 interactors of which there are 48 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for PRKDC-Interactor (?)
RFC5 RFC5: Replication factor C subunit 5 691.00 0.0278
PCNA PCNA: Proliferating cell nuclear antigen 54.70 0.144
RFC1 N/A 9.26 0.137
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 3.89 0.307
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.612 0.163
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.354 0.083
CHTF18 RUVBL, CHTF18: Protein CTF18 homolog. 0.354 0.028
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.221 0.087
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.207 0.269
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.207 0.144
MCM3 MCM3: DNA replication licensing factor MCM3 0.207 0.307
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.207 0.307
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.207 0.430
TAF9 AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6 0.137 0.059
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.137 0.0278
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.123 0.163
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.123 0.163
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.123 0.269
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.117 0.025
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.108 0.0278
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.0968 0.155
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.0968 0.575
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.0968 0.260
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.083 0.210
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.081 0.0255
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.074 0.260
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.074 0.163
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.074 0.260
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.074 0.0278
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.074 0.0278
PSMC3 PSMC3, TBP1: 26S protease regulatory subunit 6A 0.074 0.0255
FEN1 FEN1, RAD2: Flap endonuclease 1 0.0739 0.025
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.067 0.515
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.060 0.070
MDN1 MDN1, KIAA0301: Midasin 0.060 0.260
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.059 0.087
CSE1L CSE1L, CAS, XPO2: Exportin-2 0.053 0.179
CNAP1 NCAPD2, CAPD2, CNAP1, KIAA0159: Condensin complex subunit 1 0.053 0.090
CCNB1 Cyclin B1 0.051 0.144
VCP VCP: Transitional endoplasmic reticulum ATPase 0.044 0.132
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.042 0.852
SRPR SRPR: Uncharacterized protein SRPR 0.041 0.0425
RFC1 RFC1, RFC140: Replication factor C subunit 1 0.0288 0.051
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.027 0.025
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.053
C22orf18 N/A 0.027 0.027
RAD51AP1 N/A 0.027 0.027
GMNN GMNN: Geminin 0.027 0.025
0.299
Total Score 7.09