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Evidence of Interaction Between RFC4 and RAD51

The interaction score between RFC4 and RAD51 is 3.31.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismRFC4 OrthologueRAD51 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR068W 1 YER095W 1
worm P53016 1 O44246 1
fly Q9VX15 1 Q27297 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in RFC4 and RAD51:
Domains in RFC4Domains in RAD51
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR008921 DNA polymerase III clamp loader subunit, C-terminal
IPR000862 RFC
IPR013748 Replication factor C
IPR000445 Helix-hairpin-helix motif
IPR001553 RecA bacterial DNA recombination protein
IPR010214 NusA_Cterm_rpt.
IPR011941 Recomb_RAD51.

The Chi square scores for co-occurrence of domains that are present in RFC4 and RAD51 are listed below.

Domain 1Domain 2Chi Square
IPR003593 AAA ATPase IPR001553 RecA bacterial DNA recombination protein 24.0273

The background colour of the table refers to:

  • Blue Domain is only present in RFC4
  • Yellow Domain is only present in RAD51
  • Green Domain is present in both RFC4 and RAD51

 0.027
Post-translational Modifications

Protein: RFC4

PTMResidueReference

Protein: RAD51

PTMResidueReference
Phosphorylation 54 PubMed, HPRD
Phosphorylation 315 PubMed, HPRD
Phosphothreonine 309 PubMed, HPRD
Proteolytic Cleavage 187 PubMed, HPRD
Proteolytic Cleavage 274 PubMed, HPRD
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: RAD51

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between RFC4 and RAD51 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andRAD51. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and RAD51 has 1444 interactors of which there are 43 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for RAD51-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 54.70 0.025
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 3.89 0.025
KPNA6 N/A 2.37 0.354
KPNA5 KPNA5: Importin subunit alpha-6 1.18 0.354
KPNA1 KPNA1, RCH2: Importin subunit alpha-1 0.647 0.071
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.612 0.148
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.354 0.025
CHTF18 RUVBL, CHTF18: Protein CTF18 homolog. 0.354 0.025
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.221 0.025
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.207 0.148
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.207 0.148
MCM3 MCM3: DNA replication licensing factor MCM3 0.207 0.148
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.207 0.148
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.207 0.148
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.137 0.027
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.123 0.148
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.123 0.148
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.123 0.148
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.108 0.027
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.0968 6.33
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.0968 0.050
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.0968 0.148
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.0968 0.148
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.083 0.165
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.074 0.148
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.074 0.148
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.074 0.148
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.067 0.165
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.060 0.148
MDN1 MDN1, KIAA0301: Midasin 0.060 0.148
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.059 0.028
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.059 0.148
CCNB1 Cyclin B1 0.051 0.025
XRCC3 XRCC3: DNA-repair protein XRCC3 0.047 62.80
VCP VCP: Transitional endoplasmic reticulum ATPase 0.044 0.148
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.042 0.025
SRPR SRPR: Uncharacterized protein SRPR 0.041 0.165
RAD51C RAD51C, RAD51L2: DNA repair protein RAD51 homolog 3 0.030 0.0258
RFC1 RFC1, RFC140: Replication factor C subunit 1 0.0288 0.051
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
RAD51L1 RAD51L1, RAD51B, REC2: DNA repair protein RAD51 homolog 2 0.027 0.027
DNAH11 N/A 0.027 0.027
RAD51L3 RAD51L3, RAD51D: DNA repair protein RAD51 homolog 4 0.027 0.027
0.347
Total Score 3.31