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Evidence of Interaction Between RFC4 and HDAC1

The interaction score between RFC4 and HDAC1 is 1.42.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RFC4 and HDAC1 = 0.61

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology
OrganismRFC4 OrthologueHDAC1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR068W 1 YNL330C 0.674
worm P53016 1 O17695 1
fly Q9VX15 1 Q94517 0.353

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 4.28E-3
Post-translational Modifications

Protein: RFC4

PTMResidueReference

Protein: HDAC1

PTMResidueReference
Phosphorylation 421 PubMed, HPRD
Phosphorylation 423 PubMed, HPRD
Phosphoserine 421 PubMed, HPRD
Phosphoserine 423 PubMed, HPRD
Phosphotyrosine 221 HPRD
Sumoylation 444 PubMed, HPRD
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: HDAC1

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Transitive Score

The common interactors between RFC4 and HDAC1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andHDAC1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and HDAC1 has 1323 interactors of which there are 32 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for HDAC1-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 54.70 0.063
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 3.89 0.040
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.612 2.46
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.221 0.141
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.207 0.129
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.207 0.078
MCM3 MCM3: DNA replication licensing factor MCM3 0.207 0.241
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.207 0.063
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.207 0.087
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.123 0.078
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.123 0.067
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.123 0.054
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.108 0.090
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.0968 0.078
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.0968 0.275
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.083 0.0425
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.074 0.112
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.074 0.066
SRP54 SRP54: Signal recognition particle 54 kDa protein 0.074 0.042
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.074 0.112
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.074 0.042
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.067 0.052
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.060 0.046
MDN1 MDN1, KIAA0301: Midasin 0.060 0.146
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.059 0.087
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.059 0.129
CCNB1 Cyclin B1 0.051 0.139
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.047 0.038
VCP VCP: Transitional endoplasmic reticulum ATPase 0.044 0.112
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.042 0.233
SRPR SRPR: Uncharacterized protein SRPR 0.041 0.125
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.025
0.299
Total Score 1.42