Predicted interactions involving protein TYK2: Non-receptor tyrosine-protein kinase TYK2 (IPI00022353) that score above 1.0

Click on the protein name for more information about the protein.

The Score column is the predicted score of interaction between the two proteins

Click on the Evidence link to view a breakdown of the information about the predicted interaction.

Key
Module ScoreDatabases
Where interaction is observed in another database a link is provided:

Protein 1 (?)Protein 2 (?) Name of Protein 2 Module Scores (?) Scores (?) Evidence (?) Database (?)
TYK2 JAK2 JAK2: Tyrosine-protein kinase JAK2 1.38E3 Evidence
TYK2 CSK CSK: Tyrosine-protein kinase CSK 1.17E3 Evidence
TYK2 STAT6 STAT6: Signal transducer and activator of transcription 6 1.17E3 Evidence
TYK2 STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 835.0 Evidence
TYK2 BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 720.0 Evidence
TYK2 SYK SYK: Tyrosine-protein kinase SYK 720.0 Evidence
TYK2 STAT5B STAT5B: Signal transducer and activator of transcription 5B 626.0 Evidence
TYK2 LYN LYN: Tyrosine-protein kinase Lyn 613.0 Evidence
TYK2 SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 613.0 Evidence
TYK2 FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 613.0 Evidence
TYK2 NCK1 NCK1, NCK: Cytoplasmic protein NCK1 506.0 Evidence
TYK2 ZAP70 ZAP70: Uncharacterized protein ZAP70 497.0 Evidence
TYK2 DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 445.0 Evidence
TYK2 CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 416.0 Evidence
TYK2 NCK2 NCK2: Cytoplasmic protein NCK2 407.0 Evidence
TYK2 BLNK BLNK, BASH, SLP65: B-cell linker protein 392.0 Evidence
TYK2 HCK N/A 370.0 Evidence
TYK2 SLA SLA, SLAP, SLAP1: SRC-like-adapter 370.0 Evidence
TYK2 LCP2 LCP2: Lymphocyte cytosolic protein 2 364.0 Evidence
TYK2 FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 299.0 Evidence
TYK2 CRKL CRKL: Crk-like protein 268.0 Evidence
TYK2 JAK1 268.0 Evidence
TYK2 CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 263.0 Evidence
TYK2 LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 221.0 Evidence
TYK2 KIT KIT: Mast/stem cell growth factor receptor precursor 206.0 Evidence
TYK2 WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 194.0 Evidence
TYK2 PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 178.0 Evidence
TYK2 STAT2 STAT2: Signal transducer and activator of transcription 2 165.0 Evidence
TYK2 GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 162.0 Evidence
TYK2 APS SH2B2, APS: SH2B adapter protein 2 161.0 Evidence
TYK2 PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 149.0 Evidence
TYK2 PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 149.0 Evidence
TYK2 HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 148.0 Evidence
TYK2 PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 139.0 Evidence
TYK2 SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 137.0 Evidence
TYK2 ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 137.0 Evidence
TYK2 STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 135.0 Evidence
TYK2 FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 134.0 Evidence
TYK2 TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 121.0 Evidence
TYK2 STAT3 119.0 Evidence
TYK2 PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 119.0 Evidence
TYK2 RASA1 RASA1, RASA: Ras GTPase-activating protein 1 106.0 Evidence
TYK2 WASPIP N/A 101.0 Evidence
TYK2 DOK1 DOK1: Docking protein 1 91.10 Evidence
TYK2 CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 90.80 Evidence
TYK2 KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 87.80 Evidence
TYK2 KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 80.00 Evidence
TYK2 INSR INSR: Insulin receptor precursor 80.00 Evidence
TYK2 EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 79.90 Evidence
TYK2 INSL3 JAK3: Tyrosine-protein kinase JAK3 79.40 Evidence
TYK2 SNX17 SNX17, KIAA0064: Sorting nexin-17 69.40 Evidence
TYK2 RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 69.40 Evidence
TYK2 TEK TEK, TIE2: Angiopoietin-1 receptor precursor 59.50 Evidence
TYK2 CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 58.60 Evidence
TYK2 GRAP GRAP: GRB2-related adapter protein 55.80 Evidence
TYK2 EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 53.30 Evidence
TYK2 PSMA5 PSMA5: Proteasome subunit alpha type-5 53.3 Evidence
TYK2 PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 53.3 Evidence
TYK2 IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 52.50 Evidence
TYK2 MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 46.90 Evidence
TYK2 PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 46.90 Evidence
TYK2 PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 43.00 Evidence
TYK2 MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 42.00 Evidence
TYK2 HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 36.30 Evidence
TYK2 NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 35.00 Evidence
TYK2 ACTG1 ACTB: Actin, cytoplasmic 1 35.00 Evidence
TYK2 NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 33.90 Evidence
TYK2 HNRPK N/A 32.90 Evidence
TYK2 CXCR4 CXCR4: C-X-C chemokine receptor type 4 32.70 Evidence
TYK2 TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 28.90 Evidence
TYK2 MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 27.90 Evidence
TYK2 SCAP2 SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R: Src kinase-associated phosphoprotein 2 26.70 Evidence
TYK2 ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 25.00 Evidence
TYK2 QARS QARS: Glutaminyl-tRNA synthetase 25.00 Evidence
TYK2 TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 24.90 Evidence
TYK2 CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 24.90 Evidence
TYK2 SOCS1 SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1 24.90 Evidence
TYK2 GAK GAK: Cyclin G-associated kinase 24.60 Evidence
TYK2 ITGAE ITGAE: Integrin alpha-E precursor 23.00 Evidence
TYK2 PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 22.80 Evidence
TYK2 HLA-F HLA-F, HLA-5.4, HLAF: HLA class I histocompatibility antigen, alpha chain F prec 21.00 Evidence
TYK2 CDK2 CDK2: Cell division protein kinase 2 20.50 Evidence
TYK2 PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 19.10 Evidence
TYK2 PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 16.20 Evidence
TYK2 CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 15.00 Evidence
TYK2 CDC2 CDC2: Cell division control protein 2 homolog 15.00 Evidence
TYK2 SNCA SNCA, NACP, PARK1: Alpha-synuclein 15.00 Evidence
TYK2 DNM3 DNM3: Uncharacterized protein DNM3 15.00 Evidence
TYK2 PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 14.50 Evidence
TYK2 GRB7 GRB7: Growth factor receptor-bound protein 7 14.20 Evidence
TYK2 PRKAA1 N/A 13.80 Evidence
TYK2 GAB1 GAB1: GRB2-associated-binding protein 1 13.80 Evidence
TYK2 NEK3 NEK3: Serine/threonine-protein kinase Nek3 13.80 Evidence
TYK2 AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 13.40 Evidence
TYK2 LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 13.40 Evidence
TYK2 NEDD9 NEDD9, CASL: Enhancer of filamentation 1 13.40 Evidence
TYK2 RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 13.10 Evidence
TYK2 MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 12.40 Evidence
TYK2 EPOR EPOR: Erythropoietin receptor precursor 11.90 Evidence
TYK2 PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 11.70 Evidence
TYK2 RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 11.70 Evidence
TYK2 STAG2 STAG2, SA2: Cohesin subunit SA-2 11.70 Evidence
TYK2 PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 11.60 Evidence
TYK2 IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 11.40 Evidence
TYK2 CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 11.40 Evidence
TYK2 IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 11.20 Evidence
TYK2 VAV1 VAV1, VAV: Proto-oncogene vav 11.10 Evidence
TYK2 TYRO3 TYRO3, BYK, DTK, RSE, SKY: Tyrosine-protein kinase receptor TYRO3 precursor 10.40 Evidence
TYK2 IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 9.92 Evidence
TYK2 LAT LAT: Linker for activation of T-cells family member 1 9.92 Evidence
TYK2 IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 9.92 Evidence
TYK2 FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 9.92 Evidence
TYK2 CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 9.92 Evidence
TYK2 TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 9.92 Evidence
TYK2 PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 9.92 Evidence
TYK2 IRS1 IRS1: Insulin receptor substrate 1 9.89 Evidence
TYK2 IL10RB IL10RB, CRFB4, D21S58, D21S66: Interleukin-10 receptor beta chain precursor 9.84 Evidence
TYK2 PRKCE PRKCE, PKCE: Protein kinase C epsilon type 9.37 Evidence
TYK2 IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 9.14 Evidence O
TYK2 GHR GHR: Growth hormone receptor precursor 9.14 Evidence
TYK2 PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 8.92 Evidence
TYK2 RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 8.84 Evidence
TYK2 TNKS2 TNKS2, PARP5B, TANK2, TNKL: Tankyrase-2 8.81 Evidence
TYK2 PSMA6 PSMA6, PROS27: Proteasome subunit alpha type-6 8.65 Evidence
TYK2 CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 8.31 Evidence
TYK2 DNM2 N/A 7.93 Evidence
TYK2 UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 7.93 Evidence
TYK2 DAPP1 N/A 7.93 Evidence
TYK2 HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 7.59 Evidence
TYK2 MTMR6 MTMR6: Myotubularin-related protein 6 7.18 Evidence
TYK2 ACTB ACTG1, ACTB, ACTG: Actin, cytoplasmic 2 6.83 Evidence
TYK2 PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 6.78 Evidence
TYK2 MTMR1 MTMR1: Myotubularin-related protein 1 6.78 Evidence
TYK2 MRCL3 MRLC2, MLCB, RLC: Myosin regulatory light chain 2, nonsarcomeric 6.78 Evidence
TYK2 XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 6.71 Evidence
TYK2 PRLR PRLR: Prolactin receptor precursor 6.62 Evidence
TYK2 ITGB4 N/A 6.52 Evidence
TYK2 CDC42EP1 CDC42EP1, BORG5, CEP1, MSE55: Cdc42 effector protein 1 6.14 Evidence
TYK2 PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 6.01 Evidence
TYK2 SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 6.01 Evidence
TYK2 PPP1R8 N/A 6.01 Evidence
TYK2 DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 6.01 Evidence
TYK2 FCER1G FCER1G: High affinity immunoglobulin epsilon receptor subunit gamma precursor 5.95 Evidence
TYK2 ASB8 ASB8, PP14212: Ankyrin repeat and SOCS box protein 8 5.92 Evidence
TYK2 AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 5.88 Evidence
TYK2 PTPN11 N/A 5.74 Evidence
TYK2 RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 5.74 Evidence
TYK2 YWHAZ YWHAZ: 14-3-3 protein zeta/delta 5.74 Evidence
TYK2 CASP3 CASP3, CPP32: Caspase-3 precursor 5.55 Evidence
TYK2 BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 5.50 Evidence
TYK2 TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 5.27 Evidence
TYK2 PSMA4 PSMA4, PSC9: Proteasome subunit alpha type-4 5.23 Evidence
TYK2 ZYX ZYX: Zyxin 5.08 Evidence
TYK2 PTPN7 PTPN7: Tyrosine-protein phosphatase non-receptor type 7 4.84 Evidence
TYK2 BFAR BFAR, BAR, RNF47: Bifunctional apoptosis regulator 4.80 Evidence
TYK2 IGHE IGHE: Ig epsilon chain C region 4.68 Evidence
TYK2 PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 4.48 Evidence
TYK2 GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 4.01 Evidence
TYK2 CREBBP CREBBP, CBP: CREB-binding protein 3.85 Evidence
TYK2 RANBP1 RANBP1: Ran-specific GTPase-activating protein 3.69 Evidence
TYK2 NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 3.64 Evidence
TYK2 GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 3.64 Evidence
TYK2 EVL N/A 3.47 Evidence
TYK2 TTN TTN: Uncharacterized protein TTN (Fragment) 3.44 Evidence
TYK2 SREBF2 N/A 3.28 Evidence
TYK2 ZNF217 ZNF217, ZABC1: Zinc finger protein 217 3.28 Evidence
TYK2 STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 3.26 Evidence
TYK2 GUCA1C GUCA1C, GCAP3: Guanylyl cyclase-activating protein 3 3.18 Evidence
TYK2 AQP2 AQP2: Aquaporin-2 3.18 Evidence
TYK2 SHC2 N/A 3.08 Evidence
TYK2 RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 2.97 Evidence
TYK2 IREB2 IREB2: Iron-responsive element-binding protein 2 2.94 Evidence
TYK2 CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 2.77 Evidence
TYK2 TXN TXN, TRDX, TRX, TRX1: Thioredoxin 2.63 Evidence
TYK2 STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 2.63 Evidence
TYK2 NPR3 N/A 2.62 Evidence
TYK2 MATK 2.54 Evidence
TYK2 CDC42 N/A 2.54 Evidence
TYK2 CASP9 CASP9, MCH6: Caspase-9 precursor 2.54 Evidence
TYK2 NASP NASP: Nuclear autoantigenic sperm protein 2.54 Evidence
TYK2 SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 2.43 Evidence
TYK2 CAPN12 CAPN12: Calpain-12 2.43 Evidence
TYK2 FCGR2A FCGR2A: Fc of IgG, low affinity IIa, receptor 2.42 Evidence
TYK2 RHOG RHOG, ARHG: Rho-related GTP-binding protein RhoG precursor 2.29 Evidence
TYK2 BCR N/A 2.28 Evidence
TYK2 LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 2.28 Evidence
TYK2 GIT2 N/A 2.28 Evidence
TYK2 PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 2.28 Evidence
TYK2 CASP7 N/A 2.28 Evidence
TYK2 RAC1 N/A 2.28 Evidence
TYK2 DOK3 N/A 2.17 Evidence
TYK2 SIRT1 SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1 2.17 Evidence
TYK2 CRK N/A 2.10 Evidence
TYK2 SHC1 SHC1, RP11-307C12.1-001, hCG_1997126: SHC 2.10 Evidence
TYK2 CD19 N/A 1.98 Evidence
TYK2 GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 1.72 Evidence
TYK2 SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 1.72 Evidence
TYK2 IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 1.57 Evidence
TYK2 PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 1.57 Evidence
TYK2 CD48 CD48, BCM1, BLAST1: CD48 antigen precursor 1.41 Evidence
TYK2 TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 1.41 Evidence
TYK2 PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 1.41 Evidence
TYK2 FNBP1 N/A 1.41 Evidence
TYK2 LCP1 LCP1, PLS2: Plastin-2 1.41 Evidence
TYK2 SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 1.30 Evidence
TYK2 PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 1.30 Evidence
TYK2 SNAP23 SNAP23: Synaptosomal-associated protein 23 1.30 Evidence
TYK2 FLT3 FLT3, STK1: FL cytokine receptor precursor 1.29 Evidence
TYK2 FXYD5 FXYD5, DYSAD, HSPC113, IWU1, UNQ2561/PRO6241: FXYD domain-containing ion transpo 1.17 Evidence
TYK2 TXK TXK, PTK4: Tyrosine-protein kinase TXK 1.17 Evidence
TYK2 ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 1.13 Evidence
TYK2 SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 1.13 Evidence
TYK2 MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 1.13 Evidence
TYK2 LNK SH2B3, LNK: SH2B adapter protein 3 1.13 Evidence
TYK2 RIN3 N/A 1.05 Evidence
TYK2 RIN1 RIN1: Ras and Rab interactor 1 1.04 Evidence
TYK2 TESK1 TESK1: Dual specificity testis-specific protein kinase 1 1.04 Evidence
TYK2 HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 1.03 Evidence
TYK2 HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 1.03 Evidence
TYK2 PLEK PLEK, P47: Pleckstrin 1.03 Evidence
TYK2 HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 1.03 Evidence
TYK2 ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 1.01 Evidence