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The Barton Group

Predicted interactions involving protein JAK2: Tyrosine-protein kinase JAK2 (IPI00031016) that score above 25.0

Click on the protein name for more information about the protein.

The Score column is the predicted score of interaction between the two proteins

Click on the Evidence link to view a breakdown of the information about the predicted interaction.

Key
Module ScoreDatabases
Where interaction is observed in another database a link is provided:

Protein 1 (?)Protein 2 (?) Name of Protein 2 Module Scores (?) Scores (?) Evidence (?) Database (?)
JAK2 CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 2.43E5 Evidence
JAK2 STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 2.39E5 Evidence O
JAK2 STAT5B STAT5B: Signal transducer and activator of transcription 5B 1.79E5 Evidence O
JAK2 ZAP70 ZAP70: Uncharacterized protein ZAP70 1.48E5 Evidence
JAK2 FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 1.28E5 Evidence O
JAK2 STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 9.66E4 Evidence
JAK2 TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 8.47E4 Evidence O
JAK2 INSR INSR: Insulin receptor precursor 6.35E4 Evidence
JAK2 PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 5.72E4 Evidence
JAK2 PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 1.07E4 Evidence
JAK2 STAT6 STAT6: Signal transducer and activator of transcription 6 2.51E3 Evidence
JAK2 TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 1.38E3 Evidence
JAK2 SYK SYK: Tyrosine-protein kinase SYK 1.38E3 Evidence
JAK2 LYN LYN: Tyrosine-protein kinase Lyn 934.0 Evidence
JAK2 SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 932.0 Evidence
JAK2 VAV1 VAV1, VAV: Proto-oncogene vav 835.0 Evidence O
JAK2 BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 835.0 Evidence
JAK2 JAK1 674.0 Evidence
JAK2 CSK CSK: Tyrosine-protein kinase CSK 674.0 Evidence
JAK2 LCP2 LCP2: Lymphocyte cytosolic protein 2 564.0 Evidence
JAK2 HCK N/A 549.0 Evidence
JAK2 CRKL CRKL: Crk-like protein 407.0 Evidence
JAK2 SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 345.0 Evidence
JAK2 NCK2 NCK2: Cytoplasmic protein NCK2 309.0 Evidence
JAK2 CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 305.0 Evidence
JAK2 NCK1 NCK1, NCK: Cytoplasmic protein NCK1 301.0 Evidence
JAK2 PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 299.0 Evidence
JAK2 STAT3 299.0 Evidence
JAK2 LNK SH2B3, LNK: SH2B adapter protein 3 299.0 Evidence
JAK2 PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 288.0 Evidence
JAK2 LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 275.0 Evidence
JAK2 RASA1 RASA1, RASA: Ras GTPase-activating protein 1 268.0 Evidence
JAK2 GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 268.0 Evidence
JAK2 ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 268.0 Evidence
JAK2 PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 268.0 Evidence
JAK2 TXK TXK, PTK4: Tyrosine-protein kinase TXK 246.0 Evidence
JAK2 SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 209.0 Evidence O
JAK2 STAT2 STAT2: Signal transducer and activator of transcription 2 206.0 Evidence
JAK2 EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 200.0 Evidence
JAK2 EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 200.0 Evidence
JAK2 APS SH2B2, APS: SH2B adapter protein 2 200.0 Evidence
JAK2 INSL3 JAK3: Tyrosine-protein kinase JAK3 199.0 Evidence
JAK2 PTK6 PTK6, BRK: Tyrosine-protein kinase 6 196.0 Evidence
JAK2 BMX N/A 196.0 Evidence
JAK2 KIT KIT: Mast/stem cell growth factor receptor precursor 185.0 Evidence O
JAK2 SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 181.0 Evidence
JAK2 PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 178.0 Evidence
JAK2 WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 174.0 Evidence
JAK2 CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 149.0 Evidence
JAK2 TEK TEK, TIE2: Angiopoietin-1 receptor precursor 149.0 Evidence
JAK2 CRK CRK: Proto-oncogene C-crk 141.0 Evidence
JAK2 GRB10 N/A 141.0 Evidence
JAK2 FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 135.0 Evidence
JAK2 ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 134.0 Evidence
JAK2 FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 134.0 Evidence
JAK2 EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 134.0 Evidence
JAK2 EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 132.0 Evidence
JAK2 KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 132.0 Evidence
JAK2 FLT4 VEGFR3 long form 126.0 Evidence
JAK2 ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 121.0 Evidence
JAK2 PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 119.0 Evidence
JAK2 IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 115.0 Evidence
JAK2 YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 107.0 Evidence O
JAK2 RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 105.0 Evidence O
JAK2 DOK1 DOK1: Docking protein 1 105.0 Evidence
JAK2 RPS6KB1 N/A 85.20 Evidence
JAK2 MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 85.20 Evidence
JAK2 FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 80.00 Evidence
JAK2 KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 79.50 Evidence
JAK2 IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 77.90 Evidence
JAK2 CD4 CD4: T-cell surface glycoprotein CD4 precursor 77.70 Evidence
JAK2 IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 72.10 Evidence
JAK2 STAM2 STAM2: Signal transducing adapter molecule 2 71.10 Evidence
JAK2 ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 69.90 Evidence O
JAK2 HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 69.40 Evidence
JAK2 SCAP2 SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R: Src kinase-associated phosphoprotein 2 67.20 Evidence
JAK2 PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 66.00 Evidence
JAK2 LCP1 LCP1, PLS2: Plastin-2 64.00 Evidence
JAK2 RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 64.00 Evidence
JAK2 EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 62.90 Evidence
JAK2 CD2AP CD2AP: CD2-associated protein 62.90 Evidence
JAK2 ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 62.90 Evidence
JAK2 HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 62.70 Evidence
JAK2 CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 62.70 Evidence
JAK2 PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 60.60 Evidence
JAK2 IRS2 IRS2: Insulin receptor substrate 2 57.70 Evidence
JAK2 SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 55.80 Evidence
JAK2 CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 52.80 Evidence
JAK2 MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 51.50 Evidence
JAK2 PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 51.50 Evidence
JAK2 VAV3 VAV3: Protein vav-3 50.00 Evidence
JAK2 GRAP GRAP: GRB2-related adapter protein 50.00 Evidence
JAK2 NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 49.60 Evidence
JAK2 CCR5 CCR5: CCR5 receptor (Fragment) 46.30 Evidence O
JAK2 PRKCI PRKCI, DXS1179E: Protein kinase C iota type 45.90 Evidence
JAK2 GAB1 GAB1: GRB2-associated-binding protein 1 43.60 Evidence
JAK2 SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 43.60 Evidence
JAK2 NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 43.00 Evidence
JAK2 PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 42.00 Evidence
JAK2 SOCS1 SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1 40.50 Evidence O
JAK2 GRB7 GRB7: Growth factor receptor-bound protein 7 40.40 Evidence
JAK2 SH3BP5 N/A 39.10 Evidence
JAK2 CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 39.10 Evidence
JAK2 MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 38.10 Evidence
JAK2 PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 38.10 Evidence O
JAK2 PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 37.90 Evidence
JAK2 CXCR4 CXCR4: C-X-C chemokine receptor type 4 37.90 Evidence
JAK2 SNCA SNCA, NACP, PARK1: Alpha-synuclein 37.80 Evidence
JAK2 BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 36.70 Evidence
JAK2 GRB14 GRB14: Growth factor receptor-bound protein 14 35.90 Evidence
JAK2 CD44 N/A 35.00 Evidence
JAK2 S100A11 MLN70, S100A11, S100C: Protein S100-A11 34.80 Evidence
JAK2 SOS1 SOS1: Son of sevenless homolog 1 33.90 Evidence
JAK2 DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 33.90 Evidence
JAK2 NEDD9 NEDD9, CASL: Enhancer of filamentation 1 33.90 Evidence
JAK2 TYRO3 TYRO3, BYK, DTK, RSE, SKY: Tyrosine-protein kinase receptor TYRO3 precursor 33.2 Evidence
JAK2 CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 31.40 Evidence
JAK2 MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 31.20 Evidence
JAK2 HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 31.20 Evidence
JAK2 PLD2 PLD2: Phospholipase D2 31.20 Evidence
JAK2 CDK5 CDK5: Cell division protein kinase 5 31.20 Evidence
JAK2 MUSK MUSK: Muscle, skeletal receptor tyrosine protein kinase precursor 29.70 Evidence
JAK2 TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 29.10 Evidence
JAK2 PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 28.70 Evidence
JAK2 ETS2 ETS2: Protein C-ets-2 28.70 Evidence
JAK2 EPOR EPOR: Erythropoietin receptor precursor 28.70 Evidence
JAK2 COPA COPA: Coatomer subunit alpha 26.90 Evidence
JAK2 STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 26.80 Evidence
JAK2 CHP CHP: Calcium-binding protein p22 26.80 Evidence
JAK2 TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 25.70 Evidence
JAK2 DYRK3 N/A 25.3 Evidence
JAK2 WEE1 WEE1: Wee1-like protein kinase 25.3 Evidence
JAK2 NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 25.10 Evidence
JAK2 HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 25.10 Evidence
JAK2 MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 25.00 Evidence
JAK2 NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 25.00 Evidence