Welcome to LIGYSIS: A Web Server for the analysis of
biologically meaningful ligand binding sites in proteins

Search for a protein in our database with the box below or submit your own data for analysis.

LIGYSIS includes information from 26,260 structural segments of 25,003 proteins, 104,456 3D structures, 435,038 biologically relevant ligands, and 64,782 distinct binding sites.

If you use LIGYSIS web server or the LIGYSIS dataset, please cite the following references:

• Utgés et al. Classification of likely functional class for ligand binding sites identified from fragment screening. Commun Biol 7, 320 (2024). https://doi.org/10.1038/s42003-024-05970-8


• Utgés, J.S., Barton, G.J. Comparative evaluation of methods for the prediction of protein–ligand binding sites. J Cheminform 16, 126 (2024). https://doi.org/10.1186/s13321-024-00923-z