What Does NoD Do ...

NoD is a predictor of nucleolar localization sequences (NoLSs) in proteins. NoLSs are short basic motifs that localize proteins to the nucleolus, a sub-compartment of the nucleus. You can search the set of NoLSs predicted in 9531 human proteins out of the 43534 human proteins considered (from IPI version 3.40). For more information, visit the Help Document.

Accession-based search

Search whether a human protein is predicted to harbour a NoLS:
Human protein accession (eg IPI00001786):
(Currently supported identifiers include IPI, RefSeq and UniProt identifiers)

You can download the complete list of predictions for human from the download page.

Protein Sequence Prediction

Please paste your protein sequence (or use our example NOL12) in fasta format and press the Submit button. Non-standard amino acids and non-letter characters will be removed. Please only input one sequence at a time. If you wish to predict on a set of proteins then please download and run the command-line version of the predictor.

Use Jpred secondary structure predictions if available. This takes longer (10 minutes in most cases but up to 6 hours occasionally) and gives more accurate results.


* Scott MS, Boisvert FM, McDowall MD, Lamond AI, Barton GJ (2010) Characterization and prediction of protein nucleolar localization sequences, Nucleic Acids Research 38(21):7388-99, doi: 10.1093/nar/gkq653

* Michelle S. Scott, Peter V. Troshin and Geoffrey J. Barton "NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins" - BMC Bioinformatics 2011, 12:317, doi:10.1186/1471-2105-12-317.